Early left atrial dysfunction is associated with suboptimal cardiovascular health

Abstract

Aims: Two-dimensional speckle-tracking echocardiography can assess left atrial (LA) function by measuring atrial volumes and deformation parameters (strain, strain rate). This cross-sectional analysis explores the association between ideal CV health (CVH), LA function, and systemic biomarkers in healthy individuals from the Chilean MAUCO Cohort. Methods:We enrolled 95 MAUCO participants with different levels of CVH (mean age: 51 ± 8 years). We categorized participants into low or high CVH groups: A: 0-2, or B: 3-6 CVH risk factors. 2D echocardiography, glucose, insulin, total cholesterol, triglycerides, proBNP, hsCRP, insulin resistance index (HOMA), and right and left atrial strain (RASs and LASs, respectively) were determined.Results: LASs was lower in Group A, while systolic and diastolic blood pressure (BP), body mass index (BMI), insulin, HOMA, total cholesterol, triglycerides, and LV and RV end-diastolic volume were significantly higher in Group A than Group B (P < .01).Change in LASs was inversely correlated with insulin (P = .040), HOMA (P = .013), total cholesterol (P = .039), glycemia (P = .018), and BMI (P = .0.037). Conclusion:LASs during the reservoir phase was diminished in subjects with a lower level of CVH. Higher insulin, HOMA, total cholesterol, glycemia, and BMI

Association between insulin resistance and cardiac remodeling in HER2-positive breast cancer patients: a real-world study

“…For instance, a study from the University of Oxford which enrolled 4,344 UKPDS participants discovered that a doubled HOMA2-IR value in newly diagnosed T2DM patients was associated with a 5% greater risk of HF death and a 14% greater risk of HF onset over a median follow-up of 16.4 years [ 17 ]. Apart from overt HF, the predictive value of IR for subclinical cardiac adverse remodeling has also been proposed [ 19 – 21 ]. A prospective study evaluated multilayer global longitudinal strain (MGLS) of matched patients with or without IR and concluded that patients with higher HOMA-IR values had significantly lower strain values [ 22 ].…”

Echocardiographic assessment of pulmonary capillary wedge pressure in patients with frequent premature ventricular complexes

“…However, the results obtained with this method may be affected by age, heart rate, preload and afterload. Additionally, these parameters do not fully reflect the expansion of the myocardium in the middle and late diastole 10–12 …”

“…Additionally, these parameters do not fully reflect the expansion of the myocardium in the middle and late diastole. [10][11][12] Speckle tracking echocardiography (STE) shows the time-LAV curves in detail, evaluating the phasic LAV and LA functions over time.…”