Early invasive diagnostic techniques in pregnant women who are infected with the HIV: A multicenter case series

Somigliana, Edgardo; Bucceri, A.; Tibaldi, Cecilia; Alberico, Salvatore; Ravizza, Marina; Savasi, Valeria; Marini, Silvia; Matrone, Roberta; Pardi, Giorgio

doi:10.1016/j.ajog.2004.12.087

Cited by 50 publications

(26 citation statements)

References 15 publications

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“…No case of MTCT has been reported in women under HAART in other recent studies [38,47,49,50] , including a total of 78 cases. Viral load at the time of the procedure was under control in most cases, although it was not always detectable.…”

Section: Human Immunodeficiency Virusmentioning

confidence: 95%

Chronic Viral Infections and Invasive Procedures: Risk of Vertical Transmission and Current Recommendations

López

Coll

2010

Fetal Diagn Ther

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The risk of transmission of human immunodeficiency virus (HIV), hepatitis B (HBV) and hepatitis C virus (HCV) during invasive procedures may not be negligible, although it has been poorly assessed. The risk of hepatitis B transmission during amniocentesis seems to be low, but it may be increased in women with a positive HBeAg. HCV transmission risk cannot be established because evidence is lacking. No information exists about other invasive procedures in such infections. An increased risk of vertical transmission following an invasive procedure was suggested in HIV infection, but amniocentesis seems to be safe when performed under highly active antiretroviral treatment, with a low viral load and when avoiding placental passage. International guidelines do not clearly define policies to screen for maternal blood-borne virus infection during invasive procedures. Nevertheless, serological status should be assessed in all cases and parents should be aware of the existing evidence for transmission risk. Transplacental amniocentesis should always be avoided.

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Section: Human Immunodeficiency Virusmentioning

confidence: 95%

Chronic Viral Infections and Invasive Procedures: Risk of Vertical Transmission and Current Recommendations

López

Coll

2010

Fetal Diagn Ther

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“…[7][8][9][10][11][12] Recent literature suggests that it is safe to perform amniocentesis in women on HAART with suppressed viral loads (preferably undetectable) and when transplacental passage of the needle is avoided. [7,[10][11][12][13][14][15] HIV counselling and testing at the booking antenatal visit is routine, and many patients will only discover their HIV status during the pregnancy. Unfortunately, in SA many women initiate antenatal care late in pregnancy -in a recent study of over 27 000 pregnancies in the Peninsula Maternity and Neonatal Service in the Western Cape, 62% of women booked after 20 weeks [16] -thus missing the opportunity for firsttrimester screening.…”

Section: Hiv and Amniocentesismentioning

confidence: 99%

Recommendations for amniocentesis in HIV-positive women

2014

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Aneuploidy is a major cause of perinatal death and childhood handicap.[1] Improved methods of screening for aneuploidy such as the nuchal translucency (NT) scan, first-and second-trimester serum biochemistry and assessment of fetal anatomy and markers by ultrasound at 18 -22 weeks' gestation have replaced maternal age, which is known to be a poor method of screening. With improved screening methods, there is a need for diagnostic tests such as a chorionic villous sample and amniocentesis to confirm or exclude aneuploidy. These invasive tests are associated with a risk of miscarriage, and should therefore only be carried out in high-risk pregnancies.

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“…[9][10][11] In studies reporting no MTCT with combination antiretroviral therapy, a significant number of women were initiated on therapy before conception, and the majority were virally suppressed at the time of the procedure. 9 Despite the decrease in HIV transmission with antiretroviral cover, procedures that require more technical skills -such as chorionic villus sampling and cordocentesis -should still be avoided in the HIV-infected woman, as the risk of transmission to the fetus may be considerably increased.…”

Section: Risk Of Mtct With Antenatal Invasive Proceduresmentioning

confidence: 99%

How can we reduce the risk of mother-to-child transmission of HIV during invasive obstetric procedures?

Mnyani

Nicolaou

Bera

et al. 2011

South. Afr. j. HIV med.

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Antenatal invasive obstetric procedures may be diagnostic or therapeutic, and are performed at different stages of pregnancy for various indications. The commonest indication for an invasive procedure during pregnancy is for fetal karyotyping when a chromosomal abnormality or a genetic defect is suspected, either from the couple’s history or from ultrasound assessment of the fetus. Other less common but equally important indications may be diagnostic (fetoscopy, fetal tissue sampling, estimation of fetal haemoglobin) or therapeutic (aspiration of various fetal cavities, fetal blood transfusion and embryo reductions). In a high HIV prevalence setting like South Africa, a significant proportion of pregnant women in need of invasive procedures will be HIV-infected.

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Early invasive diagnostic techniques in pregnant women who are infected with the HIV: A multicenter case series

Cited by 50 publications

References 15 publications

Chronic Viral Infections and Invasive Procedures: Risk of Vertical Transmission and Current Recommendations

Chronic Viral Infections and Invasive Procedures: Risk of Vertical Transmission and Current Recommendations

Recommendations for amniocentesis in HIV-positive women

How can we reduce the risk of mother-to-child transmission of HIV during invasive obstetric procedures?

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