Early invasion of uropathogenicEscherichia coliinto the bladder wall by solitary bacteria that are protected from antibiotics and neutrophil swarms in an organoid model
Abstract:Uropathogenic Escherichia coli (UPEC) is the most common cause of urinary tract infections (UTIs) and require antibiotic therapy. Recurrent infection, which occurs in 25% of treated individuals, is thought to be caused by the release of bacteria from persistent intracellular bacterial communities (IBCs) in the outermost layer of umbrella cells in the bladder wall. Here, we present a bladder organoid model of UPEC infection that recapitulates the bladder architecture within a volume that is suitable for long-te… Show more
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