Early introduction of lipids to parenterally-fed preterm infants

Improving head growth in very preterm infants - a randomised controlled trial I: neonatal outcomes

“…There is insufficient evidence to suggest that higher lipid intake increases the risk of pulmonary morbidity or CLD. Studies have focused mainly on the early initiation of parenteral lipid and have not shown any detrimental effects 38 39…”

Early parenteral nutrition and growth outcomes in preterm infants: a systematic review and meta-analysis

“…To inform the evidence base for this study, we carried out a systematic review to investigate the effect of an early compared with late initiation of PN on growth, morbidity, and mortality in preterm infants. A previous systematic review (10) that looked specifically at the early introduction of lipids showed no benefit in the introduction of lipids ,5 d of age. We aimed to systematically analyze data from all available observational studies and randomized controlled trials (RCTs) on the effect of the timing of commencement of PN on growth and risk of morbidity and mortality in preterm infants.…”

Pharmacologic interventions for the prevention and treatment of retinopathy of prematurity

“…Administration of fish oil to preterm infants from the first day of life showed a significantly lower incidence and severity of ROP and risk of laser therapy in the treated group (213–215). However, two meta-analyses examined the potential benefits of lipid administration and found no significant benefits for the outcome of ROP (216,217). Treatment with omega-3 fatty acids appears to be a promising therapy for prevention and/or treatment of ROP, but there is a paucity of multi-center randomized clinical trials.…”