Early Intraarticular Injection of Hyaluronic Acid Attenuates Osteoarthritis Progression in Anterior Cruciate Ligament-Transected Rats

Abstract

Early intraarticular injection of HA attenuates the progression of cartilage destruction in the ACLT knee, and the downregulation of the cystine/glutamate antiporter system [Formula: see text] was accompanied by the progression of OA.

Shea Nut Oil Triterpene Concentrate Attenuates Knee Osteoarthritis Development in Rats: Evidence from Knee Joint Histology

“…Meanwhile, the surgically induced instability model of OA mimics the pathogenesis and pathology of OA induced by joint injury in humans because rupture or tear of the anterior cruciate ligament (ACL) is one of the main causes of OA in younger individuals [9]. Surgical methods to induce OA include induction of medial meniscus tear [10–12], ACL tear [13–15], partial medial meniscus tear [16], and ACL tear with partial medial meniscus tear [14,17]. Surgically induced OA in rats results in rapidly progressive degenerative changes in the cartilage, characterized by chondrocytes and proteoglycan loss, fibrillation, osteophytes formation, and chondrocyte cloning [4,18].…”

Effects of hemarthrosis on cartilage and synovium in rabbits

“…The possible mechanisms are: (1) injected HA intraarticular can improve content of HA intra-articular, cover the surface of cartilago articularis and synovium, prevent deposition of hemoglobin particles in synovial surface and permeate to enchondral, and further influence metabolism of synovium and cartilage; [10,22] (2) injected HA intraarticular can restrict diffusion of inflammatory medium via molecular sieves; [23] (3) HA can accelerate composition of self-HA in synovial cells [24]. Exogenous HA entered into articular cavity can improve the surrounding environment of synovial cells, and have a regenerative feedback role in composition of self-HA in synovial cells [7].…”

“…However, less studies report effects of hematoma on cartilage and synovium. In the study, we established hemarthrosis models by injecting autoblood in rabbits' knee-joints, [6][7][8] and observed effects of hemarthrosis on cartilage and synovium, and roles of synovium in the process [9,10]. To reduce the damage, sodium hyaluronate was added in hemarthrosis group, and we attempted to observe the improvement of sodium hyaluronate on hematoma damages by studying morphology, histochemistry and biochemistry.…”

Hyaluronic acid in the management of osteoarthritis: injection therapies innovations

“…In fact, IA-HA therapy can lead to modulation of nociceptors (32), reduction of synovial/capsular fibrosis (33), increased synthesis of higher molecular weight endogenous HA by the resident synoviocytes (33,34), and reduction in inflammatory mediators including prostaglandin-E2, IL-1 and IL-6 (35-37). Furthermore, there is significant evidence that IA-HA injections could reduce the rate of cartilage degeneration in animal models of OA (38)(39)(40) but whether the same could happen in humans is unclear. Amelioration of cartilage degradation by HA is thought to occur through enhancement of chondrocyte aggrecan synthesis (41,42), reduction of matrix degrading enzyme [matrix metalloproteinases (MMPs) (43) and disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) (44)], and modification of inflammatory cytokine expression and activity (32).…”