Early interventions for very low birth weight preterm infants: effects and mediators

Jeng, Suh‐Fang; Wu, Yu Jong; Leng, Chi-Hon; Hsieh, Wu‐Shiun; Hsu, Chyong-Hsin; Chen, W.J.; Gau, Susan Shur-Fen; Hsu, Hui‐Chin; Chen, L.-C.; Yu, Yen‐Ting; Wu, Yi Chang

doi:10.1016/j.physio.2015.03.3518

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“…Based on the inclusion criteria, 3966 studies were excluded by reading titles and abstracts and 34 articles assessed. Full-texts of 34 articles were read and 13 articles were excluded because of not having RCT design [32][33][34][35][36][37][38], intervention in both NICU and post-NICU settings [39][40][41][42][43], and intervention only in post-NICU setting [44]. Finally, 21 studies with 1528 participants were included in this systematic review.…”

Section: Study Selectionmentioning

confidence: 99%

Do NICU developmental care improve cognitive and motor outcomes for preterm infants? A systematic review and meta-analysis

et al. 2020

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Background: The aim of this study was to review the effects of developmental care in neonatal intensive care unit (NICU) setting on mental and motor development of preterm infants. Method: We searched PubMed, EMBASE, CINAHL, Scopus, Web of Science and Cochrane library until October 8th 2017, and included randomized controlled trials that assessed effects of developmental care in NICU on mental and motor development of preterm infants at 12 and 24 months of age, using the Bayley scale of infant development in this systematic review. In addition, data were pooled by random effects model and Standardized Mean Difference (SMD) with 95% confidence intervals (CI), calculated for meta-analysis. Results: Twenty one studies were eligible to be included in this systematic review; however, only thirteen studies had data suitable for meta-analysis. According to statistical analysis, developmental care in NICU improved mental developmental index (MDI) (standardized mean difference [SMD] 0.55, 95% confidence interval [CI] 0.23-0.87; p < 0.05), and psychomotor developmental index (PDI) (SMD 0.33, [CI] 95% CI 0.08-0.57; p < 0.05) of BSID at 12 months of age and PDI at 24 months of age (SMD 0.15, 95% CI-0.02-0.32; p < 0.1) of preterm infants. However, the benefit was not detected at 24 months of age on MDI (SMD 0.15, 95% CI-0.05-0.35; p = 0.15). Conclusion: Current evidence suggests that developmental care in only NICU setting could have significant effect on mental and motor development of preterm infants, especially at 12 months of age. However, because of clinical heterogeneity, more studies are needed to evaluate the effects of developmental NICU care in the development of preterm infants.

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