Early intervention with ABA prevents neuroinflammation and memory impairment in a triple transgenic mice model of Alzheimer´s disease

Espinosa-Fernández, Verónica; Mañas-Ojeda, Aroa; Pacheco-Herrero, Mar; Castro-Salazar, Ernestina; Ros-Bernal, Francisco; Sánchez-Pérez, Ana María

doi:10.1016/j.bbr.2019.112106

Cited by 20 publications

(36 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…was assessed by novel object recognition (NOR) test. NOR experiment was conducted as described [46]. On the test day, the subjects were left to explore two identical objects for 10 min (familiarization phase).…”

Section: Methodsmentioning

confidence: 99%

“…For the quantification of Iba1 labeling, we used 20×lens. Image J software combined with FracLac plugin [51] was used to analyse the microglia morphology in sections from sham and 6-OHDA groups of both females and males as previously described [46]. The microglia morphological parameters that were analysed were (1) cell area , meaning the total number of pixels corresponding to the area occupied by the cell, soma, and branches; and (2) cell perimeter , based on the single outline cell shape.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Targeting neuroinflammation with Abscisic Acid reduces pain sensitivity in females and hyperactivity in males of an ADHD mice model

Meseguer-Beltrán

Sánchez-Sarasúa

Landry

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

Aims: Attention deficit/ hyperactivity disorder (ADHD) is a neurodevelopmental syndrome characterized by dopaminergic dysfunction. In this study, we aimed to demonstrate the link between dopaminergic deficit and neuroinflammation underlying ADHD symptoms. Subjects and Treatment: We used a validated ADHD mice model, that involves perinatal 6-OHDA lesion. Animals were treated with 20mg/L (drinking water) of Abscisic acid (ABA) for one month. We tested behaviour (learning and memory, anxiety, social interactions, and pain) in both females and male mice, in all eight groups (control and lesioned, with/without ABA). Postmortem, we analyzed microglia morphology and Ape1 expression in specific brain areas related to the descending pain inhibitory pathway. Results: In females, dopaminergic deficit increased pain sensitivity, but not hyperactivity, in contrast to males. This behaviour was associated with inflammatory microglia and lower Ape1 levels in the anterior cingulate cortex (ACC) and posterior insula cortex (IC). ABA treatment reduced inflammation and alleviated pain. In males, ABA reduced hyperactivity, but had no significant effect on inflammation. Conclusions: This is the first study proving a sex-dependent association between dopamine dysfunction and inflammation in specific brain areas, leading to different behavior outcomes in a mouse model of ADHD. These findings provide new clues for potential treatments.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Targeting neuroinflammation with Abscisic Acid reduces pain sensitivity in females and hyperactivity in males of an ADHD mice model

Meseguer-Beltrán

Sánchez-Sarasúa

Landry

et al. 2022

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…In addition, we have demonstrated that ABA can improve memory in an animal model of AD, reducing neuroinflammatory markers and restoring insulin-mediating molecule expression [101][102][103]. To our knowledge, ABA has not yet been tested in clinical trials.…”

Section: Nutraceuticals As a Treatment Of Admentioning

confidence: 99%

Can We Treat Neuroinflammation in Alzheimer’s Disease?

Sánchez-Sarasúa

Fernández-Pérez

Espinosa-Fernández

et al. 2020

IJMS

Self Cite

View full text Add to dashboard Cite

Alzheimer’s disease (AD), considered the most common type of dementia, is characterized by a progressive loss of memory, visuospatial, language and complex cognitive abilities. In addition, patients often show comorbid depression and aggressiveness. Aging is the major factor contributing to AD; however, the initial cause that triggers the disease is yet unknown. Scientific evidence demonstrates that AD, especially the late onset of AD, is not the result of a single event, but rather it appears because of a combination of risk elements with the lack of protective ones. A major risk factor underlying the disease is neuroinflammation, which can be activated by different situations, including chronic pathogenic infections, prolonged stress and metabolic syndrome. Consequently, many therapeutic strategies against AD have been designed to reduce neuro-inflammation, with very promising results improving cognitive function in preclinical models of the disease. The literature is massive; thus, in this review we will revise the translational evidence of these early strategies focusing in anti-diabetic and anti-inflammatory molecules and discuss their therapeutic application in humans. Furthermore, we review the preclinical and clinical data of nutraceutical application against AD symptoms. Finally, we introduce new players underlying neuroinflammation in AD: the activity of the endocannabinoid system and the intestinal microbiota as neuroprotectors. This review highlights the importance of a broad multimodal approach to treat successfully the neuroinflammation underlying AD.

show abstract

“…Accumulated evidence from preclinical [ 10 ] and clinical trials have demonstrated that early intervention with multimodal intervention (exercise, diet, and cognitive training) [ 11 , 12 ] and/or probiotics [ 13 ] can satisfactorily delay the progress from mild cognitive impairment (MCI) to dementia. Thus, early risk prediction is crucial for health care providers to initiate effective prevention interventions, even starting decades before the first symptoms appear.…”

Section: Introductionmentioning

confidence: 99%

Prediction of Alzheimer’s Disease by a Novel Image-Based Representation of Gene Expression

Kalkan

Akkaya

Inal-Gultekin

et al. 2022

Genes

View full text Add to dashboard Cite

Early intervention can delay the progress of Alzheimer’s Disease (AD), but currently, there are no effective prediction tools. The goal of this study is to generate a reliable artificial intelligence (AI) model capable of detecting the high risk of AD, based on gene expression arrays from blood samples. To that end, a novel image-formation method is proposed to transform single-dimension gene expressions into a discriminative 2-dimensional (2D) image to use convolutional neural networks (CNNs) for classification. Three publicly available datasets were pooled, and a total of 11,618 common genes’ expression values were obtained. The genes were then categorized for their discriminating power using the Fisher distance (AD vs. control (CTL)) and mapped to a 2D image by linear discriminant analysis (LDA). Then, a six-layer CNN model with 292,493 parameters were used for classification. An accuracy of 0.842 and an area under curve (AUC) of 0.875 were achieved for the AD vs. CTL classification. The proposed method obtained higher accuracy and AUC compared with other reported methods. The conversion to 2D in CNN offers a unique advantage for improving accuracy and can be easily transferred to the clinic to drastically improve AD (or any disease) early detection.

show abstract

Early intervention with ABA prevents neuroinflammation and memory impairment in a triple transgenic mice model of Alzheimer´s disease

Cited by 20 publications

References 23 publications

Targeting neuroinflammation with Abscisic Acid reduces pain sensitivity in females and hyperactivity in males of an ADHD mice model

Targeting neuroinflammation with Abscisic Acid reduces pain sensitivity in females and hyperactivity in males of an ADHD mice model

Can We Treat Neuroinflammation in Alzheimer’s Disease?

Prediction of Alzheimer’s Disease by a Novel Image-Based Representation of Gene Expression

Contact Info

Product

Resources

About