The aim of this study was to gain insight into the experiences of mothers caring for children with autism spectrum disorders (ASD) in relation to the early life, resources and to address the consequences of raising a child with ASD in Egypt. Semi-structured interviews were conducted with 14 mothers of children with ASD in Egypt, the children were aged 5–14 years old (mean: 7.3 years). Data were thematically analysed. Results revealed that life with ASD was daunting for the Egyptian mothers. Findings suggested that provision of inadequate education, healthcare and stigma constitute the main issues for mothers. Furthermore, ASD impacted negatively on the social life, emotional wellbeing and sacrifices of mothers of children with ASD. The findings provided valuable insight into the life of mothers, revealing what life really is like for mothers caring for a child with ASD in one of the low-medium-income countries. Understanding the mothers’ experiences of caring for children with ASD is crucial in providing support and developing the services that are urgently needed in Egypt.