Early intervention for mild cognitive impairment: a randomised controlled trial

Kinsella, Glynda; Mullaly, Elizabeth; Rand, Elizabeth; Ong, Ben; Burton, Carol A.; Price, Sarah; Phillips, Margaret; Storey, Elsdon

doi:10.1136/jnnp.2008.148346

Cited by 200 publications

(178 citation statements)

References 43 publications

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“…Several studies have investigated the effect of training in the use of memory strategies on individuals with MCI, showing prospective memory (Kinsella et al, 2009), quality of life (Londos et al, 2008) and metamemory (Rapp et al, 2002) improvements. A randomized controlled trial for individuals with aMCI explored the efficacy of a memory intervention as measured by the acquisition and application of everyday memory strategies (Troyer et al, 2008).…”

Section: Memory Interventions In Mild Cognitive Impairment and Alzheimentioning

confidence: 99%

Non-pharmacological intervention for memory decline

Zanetti

2014

Neurobiology of Aging

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Non-pharmacological intervention of memory difficulties in healthy older adults, as well as those with brain damage and neurodegenerative disorders, has gained much attention in recent years. The two main reasons that explain this growing interest in memory rehabilitation are the limited efficacy of current drug therapies and the plasticity of the human central nervous and the discovery that during aging, the connections in the brain are not fixed but retain the capacity to change with learning. Moreover, several studies have reported enhanced cognitive performance in patients with neurological disease, following non-invasive brain stimulation [i.e., repetitive transcranial magnetic stimulation and transcranial direct current stimulation to specific cortical areas]. The present review provides an overview of memory rehabilitation in individuals with mild cognitive impairment and in patients with Alzheimer's disease with particular regard to cognitive rehabilitation interventions focused on memory and non-invasive brain stimulation. Reviewed data suggest that in patients with memory deficits, memory intervention therapy could lead to performance improvements in memory, nevertheless further studies need to be conducted in order to establish the real value of this approach.

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Section: Memory Interventions In Mild Cognitive Impairment and Alzheimentioning

confidence: 99%

Non-pharmacological intervention for memory decline

Zanetti

2014

Neurobiology of Aging

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“…Therefore, the potential range for improvement is likely to be far smaller in ''early'' MCI than in ''late'' MCI, resulting in bias toward the latter. Although administered in only three studies, the Multifactorial Memory Questionnaire (MMQ) may be an especially promising self-report measure given its focus on clinically relevant aspects of memory, strong psychometric properties (see Troyer & Rich, 2002, for a full description), and sensitivity to change after treatment in both healthy older adults (Carretti, Borella, Zavagnin, & De Beni, 2011) and MCI (Kinsella et al, 2009;Troyer, Murphy, Anderson, Moscovitch, & Craik, 2008).…”

Section: Methodological Challenge 4: Outcome Measuresmentioning

confidence: 99%

Cognitive Rehabilitation of Memory for Mild Cognitive Impairment: A Methodological Review and Model for Future Research

Hampstead

Gillis

Stringer

2013

J Int Neuropsychol Soc

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Several recent reviews have suggested that cognitive rehabilitation may hold promise in the treatment of memory deficits experienced by patients with mild cognitive impairment. In contrast to the previous reviews that mainly focused on outcome, the current review examines key methodological challenges that are critical for designing and interpreting research studies and translating results into clinical practice. Using methodological details from 36 studies, we first examine diagnostic variability and how the use of cutoffs may bias samples toward more severely impaired patients. Second, the strengths and limitations of several common rehabilitative techniques are discussed. Half of the reviewed studies used a multi-technique approach that precludes the causal attribution between any specific technique and subsequent improvement. Third, there is a clear need to examine the dose-response relationship since this information was strikingly absent from most studies. Fourth, outcome measures varied widely and frequently depended on neuropsychological tests with little theoretical justification or ecological relevance. Fifth, we discuss how the variability in each of these other four areas complicates efforts to examine training generalization. Overall, future studies should place greater emphasis on ecologically relevant treatment approaches and outcome measures and we propose a hierarchical model that may aid in this pursuit. (JINS, 2014, 20, 135-151)

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“…The mean effect size was moderate and significantly greater than zero (d ϭ 0.41), 95% CI [0.13, 0.69], p Ͻ .001. The heterogeneity between studies was not significant, Q(3) ϭ Horowitz-Kraus & Breznitz, 2009Schmiedek, et al 2010, comp 2 Alloway, (in press), comp. 1 Van der Molen, et al 2010, comp.…”

Section: Effects Of Working Memory Training On Visuospatial Working Mmentioning

confidence: 99%

Is working memory training effective? A meta-analytic review.

Melby‐Lervåg

Hulme

2013

Developmental Psychology

1,496

1,138

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It has been suggested that working memory training programs are effective both as treatments for attention-deficit/hyperactivity disorder (ADHD) and other cognitive disorders in children and as a tool to improve cognitive ability and scholastic attainment in typically developing children and adults. However, effects across studies appear to be variable, and a systematic meta-analytic review was undertaken. To be included in the review, studies had to be randomized controlled trials or quasi-experiments without randomization, have a treatment, and have either a treated group or an untreated control group. Twenty-three studies with 30 group comparisons met the criteria for inclusion. The studies included involved clinical samples and samples of typically developing children and adults. Meta-analyses indicated that the programs produced reliable short-term improvements in working memory skills. For verbal working memory, these near-transfer effects were not sustained at follow-up, whereas for visuospatial working memory, limited evidence suggested that such effects might be maintained. More importantly, there was no convincing evidence of the generalization of working memory training to other skills (nonverbal and verbal ability, inhibitory processes in attention, word decoding, and arithmetic). The authors conclude that memory training programs appear to produce short-term, specific training effects that do not generalize. Possible limitations of the review (including age differences in the samples and the variety of different clinical conditions included) are noted. However, current findings cast doubt on both the clinical relevance of working memory training programs and their utility as methods of enhancing cognitive functioning in typically developing children and healthy adults.

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Early intervention for mild cognitive impairment: a randomised controlled trial

Abstract: Early intervention for memory difficulties in amnestic mild cognitive impairment, using cognitive rehabilitation in compensatory strategies, can assist in minimising everyday memory failures as evaluated by performance on prospective memory tasks and knowledge of memory strategies.

Cited by 200 publications

References 43 publications

Non-pharmacological intervention for memory decline

Non-pharmacological intervention for memory decline

Cognitive Rehabilitation of Memory for Mild Cognitive Impairment: A Methodological Review and Model for Future Research

Is working memory training effective? A meta-analytic review.

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