Early insulin release following suckling in neonatal lambs and rabbits

Porter, R.; Bassett, J. M.

doi:10.1007/bf01219799

Cited by 24 publications

(17 citation statements)

References 22 publications

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“…In view of the marked elevation on plasma cortisol concentrations ( Figure 2b) and the known gluconeogenic effects of cortisol (Porter and Bassett 1979;Bassett and Alexander 1991;Bassett 1992), it was surprising that the plasma glucose concentrations, which remained in the normoglycaemic range (Mellor 1987), did not increase signifi cantly after ring placement in this study. The reasons for this are unknown.…”

Section: Discussionmentioning

confidence: 73%

Blood pressure, heart rate, hormonal and other acute responses to rubber-ring castration and tail docking of lambs

Peers

Mellor²,

Wintour

et al. 2002

New Zealand Veterinary Journal

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Section: Discussionmentioning

confidence: 73%

Blood pressure, heart rate, hormonal and other acute responses to rubber-ring castration and tail docking of lambs

Peers

Mellor²,

Wintour

et al. 2002

New Zealand Veterinary Journal

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“…Recent evidence suggests that differences in parasympathetic nervous system activity before weaning may be responsible for the greater responsiveness of the fa/ fa pancreas to exogenous glucose (Rohner- Jeanrenaud, Hochstrasser and Jeanrenaud 1983). It is possible that as a consequence of sucking, insulin concentration in plasma may be transiently elevated in fa/fa rats, either in response to ingested nutrients or as one of the neural and gastrointestinal reflexes triggered by sucking (Porter and Bassett 1979). Plasma concentrations of corticosterone did not differ between phenotypes at either sampling time in 18 day old rats (Table 2) or following the stress of intra-gastric intubation of a glucose solution.…”

Section: Discussionmentioning

confidence: 98%

Hormonal Studies of Young Lean and Obese Zucker Rats

Fletcher¹,

Haggarty²,

Wahle³

et al. 1986

Horm Metab Res

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Plasma concentrations of insulin, corticosterone, T3, T4 and glucose were measured at 6 hour intervals throughout 24 hours in undisturbed, 34-day-old lean (Fa/?) and genetically obese (fa/fa) Zucker rats. fa/fa rats had higher plasma concentrations of insulin at all sampling times and higher plasma concentrations of corticosterone at 0300 and 0900 hours. Neither T3 nor T4 levels differed between phenotypes at any sampling time. Fasting for 24 hours at 34 days abolished the hyperinsulinaemia of fa/fa rats and raised the plasma corticosterone concentrations of both phenotypes. Before weaning there were no phenotypic differences in the plasma insulin or corticosterone concentrations measured at two sampling times in undisturbed rats. Following an intra-gastric glucose load however, fa/fa rats became hyper-insulinaemic compared with similarly treated Fa/? animals. Pancreatic insulin contents were higher in fa/fa rats at 34 days of age, but not before weaning. Somatostatin contents of the pancreas, hypothalamus and cerebral cortex did not differ between phenotypes at either 18 or 34 days of age. In conclusion, the elevated plasma concentrations of insulin and corticosterone in young fa/fa rats may contribute to their greater lipid deposition and lower protein deposition.

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“…Since no attempts were made to influence feeding patterns in these lambs and since all experiments were performed after a 75-to 90-min fasting period, the role of feeding and gastrointestinal hormone secretion [5] in the development of the 'adult pattern' of insulin secretion is presently unknown. Recent re ports [1,20] suggest that the early phase of insulin secretion can be elicited in the neo nate after several days in response to oral feedings. The composition of the feed may significantly alter this response qualitatively, as well as quantitatively.…”

Section: Discussionmentioning

confidence: 99%

Maturation of Early-Phase Insulin Release in the Neonatal Lamb

1981

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Standardized primed continuous glucose infusions were performed in 13 newborn lambs between 4 h and 2 weeks of age to assess the timing of development of glucose-induced early-phase insulin release. Lambs of less than 6 h of age behaved similar to those previously infused in utero, with no early response noted. In contrast, early-phase insulin release was present in lambs of 12 h of age and older. Although basal plasma glucose rose with increasing post-natal age, this rise was not sufficient to account for the appearance of early-phase insulin release. Factors other than the basal glucose level or the birth process itself may be operative.

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Early insulin release following suckling in neonatal lambs and rabbits

Cited by 24 publications

References 22 publications

Blood pressure, heart rate, hormonal and other acute responses to rubber-ring castration and tail docking of lambs

Blood pressure, heart rate, hormonal and other acute responses to rubber-ring castration and tail docking of lambs

Hormonal Studies of Young Lean and Obese Zucker Rats

Maturation of Early-Phase Insulin Release in the Neonatal Lamb

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