Early Inhibition of Prostaglandin Synthesis by n-3 Fatty Acids Determinates Histologic Severity of Necrotizing Pancreatitis

Kilian, M.; Gregor, J. I.; Heukamp, I.; Wagner, C. M.; Walz, Martin K.; Schimke, Ingolf; Kristiansen, G.; Wenger, F. A.

doi:10.1097/mpa.0b013e318198283b

Cited by 10 publications

(7 citation statements)

References 37 publications

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“…Our data also corroborate with a previous study reporting lower lipid peroxidation in the liver of rats receiving exclusive parenteral nutrition and rats with necrotizing pancreatitis receiving FOLE. 6,37 Our data also are in tune with those of a previous study reporting a lower risk for peroxidation in patients receiving home parenteral nutrition with FOLE, regardless of the presence of comorbidities. 38 However, our findings are not in agreement with a study observing that in patients with type 2 diabetes mellitus, F2-isoprostane concentrations were not affected by a FOLE.…”

Section: Discussionsupporting

confidence: 89%

Effect of a parenteral fish‐oil‐containing lipid emulsion on liver lipid perioxidation and antioxidative defenses in Lewis rats

Filho

Torrinhas

Tesser

et al. 2023

J Parenter Enteral Nutr

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Background: Eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), naturally abundant in fish oil (FO), are known for their anti-inflammatory and potential antioxidant properties. The aim in this article is to evaluate the effect of the infusion of a parenteral FO-containing lipid emulsion on markers of liver lipid peroxidation and oxidative stress in rats undergoing central venous catheterization (CVC). Methods: After 5-day acclimatization, adult Lewis rats (n = 42) receiving a 20-g/day AIN-93M oral diet were randomly subdivided into four groups: (1) basal control (BC) (n = 6), without CVC or LE infusion; (2) SHAM (n = 12), with CVC but without LE infusion; (3) soybean oil (SO)/medium-chain triglyceride (MCT) (n = 12), with CVC and receiving LE without FO (4.3 g/kg fat); and (4) SO/MCT/FO (n = 12), with CVC and receiving LE containing 10% FO (4.3 g/kg fat). Animals from the BC group were euthanized immediately after acclimatization. The remaining groups of animals were euthanized after 48 or 72 h of surgical follow-up to assess profiles of liver and plasma fatty acids by gas chromatography, liver gene transcription factor Nrf2, F2isoprostane lipid peroxidation biomarker, and the antioxidant enzymes glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) by enzyme-linked immunosorbent assay. R program (version 3.2.2) was utilized for data analysis.Results: Compared with the other groups, liver EPA and DHA levels were higher in the SO/MCT/FO group, which also showed the highest liver Nrf2, GPx, SOD, and CAT levels and lower liver F2-isoprostane (P < 0.05). Conclusion:Experimental delivery of FO via EPA and DHA sources in a parenteral LE was associated with a liver antioxidant effect.

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Section: Discussionsupporting

confidence: 89%

Effect of a parenteral fish‐oil‐containing lipid emulsion on liver lipid perioxidation and antioxidative defenses in Lewis rats

Filho

Torrinhas

Tesser

et al. 2023

J Parenter Enteral Nutr

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“…237 ). It has been demonstrated that the effect of LC n-3 PUFA on pancreatic function may be mediated by inhibition of PG and pro-inflammatory cytokine synthesis 238,239 . Particularly, the anticarcinogenic properties of LC n-3 PUFA, which are mainly attributed to altered PG formation due to COX-2 inhibition, may prove beneficial in pancreatic cancer 240 .…”

Section: Critically Ill Patients Cancer and Other Chronic Diseasesmentioning

confidence: 99%

Fatty Acids as Biocompounds: Their Role in Human Metabolism, Health and Disease - A Review. Part 2: Fatty Acid Physiological Roles and Applications in Human Health and Disease

Kremmyda¹,

Tvrzická²,

Staňková³

et al. 2011

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

152

134

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Background. This is the second of two review parts aiming at describing the major physiological roles of fatty acids, as well as their applications in specific conditions related to human health.Results. The review included the current literature published in Pubmed up to March 2011. In humans, fatty acids are a principle energy substrate and structural components of cell membranes (phospholipids) and second messengers. Fatty acids are also ligands of nuclear receptors affecting gene expression. Longer-chain (LC) polyunsaturated fatty acids (PUFA), including eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and arachidonic acid are precursors of lipid mediators such as eicosanoids (prostaglandins, leukotrienes, thromboxanes), resolvins and neuroprotectins. Lipid mediators produced by EPA and DHA (LC n-3 PUFA; mainly found in oily fish) are considered as inflammation-resolving, and thus, fish oil has been characterised as antiinflammatory. Recommendations for EPA plus DHA intake from oily fish vary between 250-450 mg/day. Dietary reference values for fat vary between nutrition bodies, but mainly agree on a low total and saturated fat intake. The existing literature supports the protective effects of LC n-3 PUFA (as opposed to n-6 PUFA and saturated fat) in maternal and offspring health, cardiovascular health, insulin sensitivity, the metabolic syndrome, cancer, critically ill patients, and immune system disorders.Conclusion. Fatty acids are involved in multiple pathways and play a major role in health. Further investigation and a nutrigenomics approach to the effects of these biocompounds on health and disease development are imperative and highlight the importance of environmental modifications on disease outcome.humans. Thus, these FA may be characterised as conditionally essential depending on EFA availability. Genetic variation in human desaturase genes affects FA metabolism, plasma lipid profiles, and risk of disease development [5][6][7] . Recommendations for minimum dietary intake of EPA plus DHA vary between 250-450 mg/day 8 , especially for pregnant women and those of reproductive age. Rich sources of LC n-3 PUFA are fish oils and the flesh of oily fish, whereas non-oily (white) fish contain them but in lower amounts.Long-chain PUFA with 18-20 carbon atoms, including EPA and AA, are precursors of eicosanoids (prostaglandins, leucotrienes and thromboxanes), which have a broad scale of regulatory, autocrine and paracrine effects. Long-chain PUFA with 20 and 22 carbon atoms are precursors of autacoids -resolvins (resolution phase interaction products), lipoxins and neuroprotectins 9 . FA are also ligands of nuclear receptors which take part in the subcellular control of metabolic pathways. Covalent modification of proteins by FA acylation enables their incorporation into membranes. Hydroxy FA are activators of some nuclear factors and are responsible for the expression of proinflammatory cytokines (interleukin (IL)-1,

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“…Відносний сумарний вміст ПНЖК ро-дини ω-6 також зменшується через 3 доби на 13% , а через 7 діб на 16% внаслідок знижен-ня відносного вмісту С 18:2 (ω-6) -лінолевої кислоти на 21 та 25% у відповідні терміни. Відомо, що зниження вмісту лінолевої кис-лоти, попередника біосинтезу арахідонової кислоти, із послідуючим циклооксигеназним її метаболізмом супроводжується утворенням прозапальних медіаторів: лейкотрієнів, зо-крема ЛтВ 4 , простагландинів E 2 та F1α [30]. Одержані дані свідчать про те, що у ПЗ за ГП відбуваються зміни жирнокислотного складу ліпідів.…”

Section: рис 7 активність фла 2 у плазмі крові щурів за гострого паunclassified

Oxidative stress in blood leukocytes, pro/antioxidanт status and fatty acids composition of pancreas lipids at experimental acute pancreatitis in rats

Pryvrotska¹,

Kuchmerovska²

2013

Ukr.Biochem.J.

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Early Inhibition of Prostaglandin Synthesis by n-3 Fatty Acids Determinates Histologic Severity of Necrotizing Pancreatitis

Abstract: Parenteral therapy with n-3 fatty acids decreased histopathologic severity in ANP by early inhibition of prostaglandin (E2 and F1alpha) synthesis and reduction of lipid peroxidation.

Cited by 10 publications

References 37 publications

Effect of a parenteral fish‐oil‐containing lipid emulsion on liver lipid perioxidation and antioxidative defenses in Lewis rats

Effect of a parenteral fish‐oil‐containing lipid emulsion on liver lipid perioxidation and antioxidative defenses in Lewis rats

Fatty Acids as Biocompounds: Their Role in Human Metabolism, Health and Disease - A Review. Part 2: Fatty Acid Physiological Roles and Applications in Human Health and Disease

Oxidative stress in blood leukocytes, pro/antioxidanт status and fatty acids composition of pancreas lipids at experimental acute pancreatitis in rats

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