Early Infant Multivitamin Supplementation Is Associated With Increased Risk for Food Allergy and Asthma

Milner, Joshua D.; Stein, Daniel M.; McCarter, Robert; Moon, Rachel Y.

doi:10.1542/peds.114.1.27

Cited by 144 publications

(130 citation statements)

References 29 publications

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“…As Table 1 shows, the prevalence of supplement use was 15% among young children up to the age of 6 y, indicating that the supplement use among young Japanese children is not as prevalent as in the United States (17,20,22,(26)(27)(28). There are supplements that have been specially designed for children, but 69% of the parents of the supplement non-user children were unaware of the existence of such supplements.…”

Section: Discussionmentioning

confidence: 99%

“…Some reports suggest that excessive nutrient intake or premature use of supplements is a health risk (22,27), and other reports describe a lack of difference in nutrient intake from food between those children using and not using supplements (22,32). In children who are still in the process of forming healthy dietary habits and are growing rapidly, reliance on supplements may result in a disregard for the importance of healthy daily eating habits.…”

Section: Discussionmentioning

confidence: 99%

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Use of Dietary Supplements among Preschool Children in Japan

Sato

Yamagishi

Hashimoto

et al. 2009

J Nutr Sci Vitaminol

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Summary This study was conducted to examine the characteristics and use of dietary supplements by preschool children in Japan. A survey was conducted among 2,125 parents of preschool children to discover the status of dietary supplement use and their attitudes towards supplement use by their children. Logistic regression models were used to determine which characteristics predict supplement use in this population. For detailed characterization, child supplement users were also categorized as either the users of vitamins and minerals only or the users of other supplement components. For parents of non-user children, the parent's knowledge and attitudes toward supplements for children were investigated. Fifteen percent of children had used dietary supplements. Two parent-related factors were especially important, the frequency with which they referred to nutritional labels and their own supplement use, which had a significant encouraging effect on their children's supplement use. The parents of child supplement users showed limited awareness of the government system concerning diet and food, placed safety over efficacy, selected products with natural ingredients, and did not seek consultations with professionals. These parents, especially those who were aware of the specially designed supplements for children, exhibited positive responses to supplement use by their children. It is likely that parents' knowledge and attitudes toward dietary supplements and nutrition have a striking effect on their children's use of supplements. Unfortunately, their knowledge at present was less than satisfactory. More accurate information on nutrition, dietary intake and dietary supplements must be disseminated.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Use of Dietary Supplements among Preschool Children in Japan

Sato

Yamagishi

Hashimoto

et al. 2009

J Nutr Sci Vitaminol

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show abstract

“…Because the associations between specific childhood food allergies, asthma, and atopic conditions have not been well characterized, we additionally used multivariable logistic regression to assess the cross-sectional associations between food allergy and current asthma, current allergic rhinitis, and current atopic dermatitis. Given the known associations between food allergy and sex 30 , age 30 , family history of allergy, 30, 31 maternal education 32 , and breastfeeding 32 , we adjusted all models for these variables (Model 1). We created secondary models additionally adjusted for race/ethnicity (Model 2).…”

Section: Statistical Analysesmentioning

confidence: 99%

Peanut, Milk, and Wheat Intake During Pregnancy Is Associated With Reduced Allergy and Asthma In Children

Bunyavanich

Rifas‐Shiman

Platts‐Mills

et al. 2014

Journal of Allergy and Clinical Immunology

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“…It has been suggested that there is a connection between vitamin D exposure early in life and the risk of developing asthma and allergies [1][2][3]. The active form of vitamin D (1,25-dihydroxyvitamin D3; 1,25(OH) 2 D 3 ) can modulate the immune response with beneficial effects on autoimmune diseases (reviewed in [4]).…”

Section: Introductionmentioning

confidence: 99%

Vitamin D receptor expression by the lung micro-environment is required for maximal induction of lung inflammation

Wittke¹,

Chang²,

Froicu³

et al. 2007

Archives of Biochemistry and Biophysics

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Mice lacking the vitamin D receptor (VDR) are resistant to airway inflammation. Pathogenic immune cells capable of transferring experimental airway inflammation to wildtype (WT) mice are present and primed in the VDR KO mice. Furthermore, the VDR KO immune cells homed to the WT lung in sufficient numbers to induce symptoms of asthma. Conversely, WT splenocytes, Th2 cells and hematopoetic cells induced some symptoms of experimental asthma when transferred to VDR KO mice, but the severity was less than that seen in the WT controls. Interestingly, experimentally induced vitamin D deficiency failed to mirror the VDR KO phenotype suggesting there might be a difference between absence of the ligand and VDR deficiency. Lipopolysaccharide (LPS) induced

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Early Infant Multivitamin Supplementation Is Associated With Increased Risk for Food Allergy and Asthma

Abstract: Early vitamin supplementation is associated with increased risk for asthma in black children and food allergies in exclusively formula-fed children. Additional study is warranted to examine which components most strongly contribute to this risk.

Cited by 144 publications

References 29 publications

Use of Dietary Supplements among Preschool Children in Japan

Use of Dietary Supplements among Preschool Children in Japan

Peanut, Milk, and Wheat Intake During Pregnancy Is Associated With Reduced Allergy and Asthma In Children

Vitamin D receptor expression by the lung micro-environment is required for maximal induction of lung inflammation

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