J. Neurosci. Res. volume 86, issue 11, P2524-2534 2008 DOI: 10.1002/jnr.21700 View full text
Sarah K. McCann, Gregory J. Dusting, Carli L. Roulston

Abstract: Oxidative stress contributes to the progression of brain injury following ischemic stroke and reperfusion. NADPH oxidase is a well-established source of superoxide in vascular disease, but its contribution to tissue injury following ischemic stroke has yet to be fully elucidated. Here we show the spatiotemporal profile of NADPH oxidase subunits Nox2 and Nox4 and concurrent superoxide generation following stroke induced by middle cerebral artery constriction in conscious rats. Nox2 mRNA was progressively up-reg…

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