Early Increase in Autoantibodies Against Human Oxidized Low-Density Lipoprotein in Hypertensive Patients After Blood Pressure Control

Brandão, Sérgio Augusto Bueno; Izar, Maria Cristina; Fischer, Sven; Santos, Ana Beatriz; Monteiro, Camila Nascimento; Póvoa, Rms; Helfenstein, Tatiana; Carvalho, Antonio C.C; Monteiro, Aílton Rocha; Ramos, Eduardo Valdés; Gidlund, Magnus; Neto, A. M. Figueiredo; Fonseca, Francisco Antônio Helfenstein

doi:10.1038/ajh.2009.214

Cited by 27 publications

(14 citation statements)

References 36 publications

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“…Flow-mediated dilation was performed as previously reported [16,17], using a Hewlett Packard ultrasound (model DR5315, USA) and measured with a high frequency ultrasound scanning probe (7 MHz).…”

Section: Methodsmentioning

confidence: 99%

Effects of High-Intensity Training of Professional Runners on Myocardial Hypertrophy and Subclinical Atherosclerosis

et al. 2016

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To evaluate the effects of long-term exposure to high-intensity training among professional runners on cardiac hypertrophy and subclinical atherosclerosis.Prospective study included runners of both sexes (n = 52) and age and gender matched controls (n = 57), without classical cardiovascular risk factors. Ventricular hypertrophy was quantified by echocardiography by linear method and carotid intima-media thickness (cIMT) by 2-D images obtained by ultrasonography. Endothelial function was evaluated by flow-mediated dilation (FMD). Steroid hormones were quantified by HPLC followed by LC-MS/MS. Higher left ventricular (LV) mass index was found in male athletes (p<0.0001 vs. other groups). When adjusted for gender, the degree of left ventricular mass index classified as mildly, moderately or severely abnormal was obtained in 26%, 35%, and 30%, respectively, of female athletes, and in 39%, 14%, and 21%, respectively, of male athletes. Higher ratio of the early (E) to late (A) ventricular filling velocities was found in athletes of both genders. Male athletes presented lower cIMT in the right (p = 0.012 vs. male controls) and left (p<0.0001 vs. male controls) common carotid arteries, without differences in cIMT between female athletes and controls. FMD results were similar among groups. Higher serum testosterone levels were found in male athletes (p<0.0001 vs. other groups) and they were correlated with LV mass (r = 0.50, p<0.0001). The chronic exposure of high-intensity training among professional runners of both genders was associated with increased ventricular mass and adaptive remodeling. Less subclinical atherosclerosis was found in male athletes. Differences in steroid hormones may account in part for these findings.

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Section: Methodsmentioning

confidence: 99%

Effects of High-Intensity Training of Professional Runners on Myocardial Hypertrophy and Subclinical Atherosclerosis

et al. 2016

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“…Several RCTs compared three or more types of antihypertensive drugs [21, 23, 25, 29, 49]. One RCT investigated the effects of the ACEI perindopril (2–4 mg/day, n = 28), the ARB telmisartan (80–160 mg/day, n = 29), the CCB, nifedipine (30–60 mg/day, n = 28), the CCB amlodipine (5–10 mg/day, n = 28), the β -blocker atenolol (50–100 mg/day, n = 29), and the β -blocker nebivolol (5–10 mg/day, n = 28) on FMD [21].…”

Section: Clinical Trials Using Fmdmentioning

confidence: 99%

“…The balance between endothelial impairment and repair is a major determinant of endothelial function. Of note, there have been trials that measured biochemical markers such as NO, oxidative stress, and inflammatory markers, in addition to FMD [17, 18, 22, 23, 27, 29, 31, 32, 35, 37, 38, 41, 43, 44, 46, 49, 51–53]. One RCT compared the CCB azelnidipine (16 mg/day) with the CCB benidipine (4 mg/day) in a cross-over design with 8 weeks on each drug [37].…”

Section: Mechanisms Of the Improvement Of Fmdmentioning

confidence: 99%

The Effect of Antihypertensive Drugs on Endothelial Function as Assessed by Flow-Mediated Vasodilation in Hypertensive Patients

Miyamoto

Kotani

Ishibashi

et al. 2012

International Journal of Vascular Medicine

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Endothelial dysfunction is found in hypertensive patients and may serve as a prognostic marker of future cardiovascular events. Endothelial function can be assessed noninvasively by flow-mediated vasodilation (FMD). The goal of this paper is to summarize comprehensively the clinical trials that investigated the effects of antihypertensive drugs on endothelial function assessed by FMD in hypertensive patients. A PubMed-based search found 38 clinical trial papers published from January 1999 to June 2011. Significant improvement of FMD after antihypertensive treatment was shown in 43 of 71 interventions (among 38 clinical trial papers). Angiotensin II receptor blockers and angiotensin converting enzyme inhibitors appeared to improve FMD more than other drug types. Antihypertensive treatment can improve endothelial dysfunction when assessed by FMD, although there are conflicting data that require further research.

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“…In agreement with this concept, a previous study involving smokers, subjects with increased oxidative milieu, found decreased oxLDL autoantibodies levels. 28 Anti-oxLDL Abs can be detected in healthy individuals, 28 but also in many other inflammatory conditions, such as periodontitis, 29 systemic lupus erythematosus, 12 as well as in chronic non-communicable diseases, like hypertension, 30 diabetes, 31 heart failure, 32 and in end-stage renal disease. 33 We have previously demonstrated that in healthy middle-aged subjects, these titers were higher than in ACS.…”

Section: Discussionmentioning

confidence: 99%

Adaptive immunity is related to coronary artery disease severity after acute coronary syndrome in subjects with metabolic syndrome

Izar

Fonseca

Pinheiro

et al. 2012

Diabetes and Vascular Disease Research

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Metabolic syndrome (MetS) is an inflammatory state associated with high coronary disease risk. Inflammation and adaptive immunity modulate atherosclerosis and plaque instability. We examined early changes in anti-oxidized lowdensity lipoprotein (LDL) (anti-oxLDL) autoantibodies (Abs) in patients with MetS after an acute coronary syndrome (ACS). Patients of both genders (n=116) with MetS were prospectively included after an acute myocardial infarction (MI) or hospitalization due to unstable angina. Anti-oxLDL Abs (IgG class) were assayed at baseline, three and six weeks after ACS. The severity of coronary disease was evaluated by the Gensini score. We observed a decrease in anti-oxLDL Abs titers (p<0.002 vs. baseline), mainly in males (p=0.01), in those under 65 y (p=0.03), and in subjects with Gensini score above median (p=0.04). In conclusion, early decrease in circulating anti-oxLDL Abs is associated with coronary disease severity among subjects with MetS.

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Early Increase in Autoantibodies Against Human Oxidized Low-Density Lipoprotein in Hypertensive Patients After Blood Pressure Control

Cited by 27 publications

References 36 publications

Effects of High-Intensity Training of Professional Runners on Myocardial Hypertrophy and Subclinical Atherosclerosis

Effects of High-Intensity Training of Professional Runners on Myocardial Hypertrophy and Subclinical Atherosclerosis

The Effect of Antihypertensive Drugs on Endothelial Function as Assessed by Flow-Mediated Vasodilation in Hypertensive Patients

Adaptive immunity is related to coronary artery disease severity after acute coronary syndrome in subjects with metabolic syndrome

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