Early in-hospital variation of red blood cell distribution width predicts mortality in patients with acute heart failure

Turcato, Gianni; Zorzi, Elisabetta; Prati, Daniele; Ricci, Giorgio; Bonora, Antonio; Zannoni, M; Antonio, Miguel; Salvagno, Gian Luca; Sanchís-Gomar, Fabián; Cervellin, Gianfranco; Lippi, Giuseppe

doi:10.1016/j.ijcard.2017.05.023

Cited by 25 publications

(35 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, it was shown that RDW 1 year after discharge was significantly higher in HF patients with DM compared to non‐diabetic HF patients . It has been demonstrated that increased RDW after 4 days of hospitalization, increased risk of 30‐day mortality up to fourfold in patients with acute decompensated HF, suggesting that these patients with elevated RDW require more care in the first days of hospitalization …”

Section: Prognostic and Diagnostic Value Of Rdw In Heart Failurementioning

confidence: 99%

The diagnostic and prognostic value of red cell distribution width in cardiovascular disease; current status and prospective

et al. 2019

View full text Add to dashboard Cite

The red blood cell distribution width (RDW) is an index of the heterogeneity of circulating red blood cell size, which along with other standard complete blood count (CBC) parameters are used to identify hematological system diseases. Besides hematological disorders, several clinical studies have shown that an increased in the RDW may be associated with other diseases including acute pancreatitis, chronic kidney disease, gastrointestinal disorders, cancer, and of special interest in this review, cardiovascular disease (CVD). The diagnostic and prognostic value of RDW in different CVD (acute coronary syndrome, ischemic cerebrovascular disease, peripheral artery disease, atrial fibrillation, heart failure, and acute ischemic stroke) has been reviewed in this article, to provide an understanding how its measurement may be applied to improve the management of these conditions.

show abstract

Section: Prognostic and Diagnostic Value Of Rdw In Heart Failurementioning

confidence: 99%

The diagnostic and prognostic value of red cell distribution width in cardiovascular disease; current status and prospective

et al. 2019

View full text Add to dashboard Cite

show abstract

“…6,8,25 In-hospital elevation of RDW is associated with increased mortality in HF patients. 7,22 In contrast, RDW decrement during hospitalization is not fully documented. In the present study, in-hospital RDW was not reduced significantly (P = 0.09, n = 64), despite the successful treatment of HF yielding a marked reduction in BNP (P < 0.01).…”

Section: Discussionmentioning

confidence: 99%

“…Many investigations have used RDW on admission as a parameter predicting mortality and morbidity of HF, and some studies investigated serial changes of RDW during hospitalization . In‐hospital elevation of RDW is associated with increased mortality in HF patients . In contrast, RDW decrement during hospitalization is not fully documented.…”

Section: Discussionmentioning

confidence: 99%

“…In this decade, this intriguing laboratory marker has been reported to have a prognostic value in cardiovascular and cerebrovascular diseases . Current evidence has suggested that RDW is useful to predict cardiac events and adverse outcomes in patients with HF . However, the results are conflicting in detail, which might reflect the complexity and heterogeneity of HF in the geriatric population.…”

Section: Introductionmentioning

confidence: 99%

“…[2][3][4][5] Current evidence has suggested that RDW is useful to predict cardiac events and adverse outcomes in patients with HF. [6][7][8] However, the results are conflicting in detail, which might reflect the complexity and heterogeneity of HF in the geriatric population. Meanwhile, senile bacterial infection is frequent in the community, and such infection affects RDW.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prognostic significance of red cell distribution width in hospitalized older patients with heart failure or infection

Nakashima

Ohgami

Kato

et al. 2019

Geriatrics Gerontology Int

View full text Add to dashboard Cite

Aim Red cell distribution width (RDW) is a simple, sensitive and cost‐effective parameter, and is associated with pathophysiology of many common diseases. The aim of the present study was to investigate the prognostic role of RDW in older adults hospitalized for the treatment of heart failure (HF) or infection, because both diseases are fatal, especially in the geriatric population. Methods This observational study consecutively enrolled 196 Japanese older (aged ≥75 years) patients hospitalized for the treatment of HF (group A, n = 102) or non‐cardiovascular bacterial infection (group B, n = 94). Baseline and clinical data were extracted from medical records. The observational period was that of hospitalization. The primary end‐point was classified in the order of discharge to the patients’ home, discharge to other facilities and in‐hospital death. Results Longer hospital stay (P < 0.01) and worse prognosis (P < 0.01), including higher in‐hospital mortality, were found in patients showing RDW ≥15% relative to those with RDW <15% in both groups. RDW showed no in‐hospital variation despite successful treatment of acutely decompensated HF in selected patients of group A (n = 64). Conclusions The present study showed the role of RDW in predicting the prognostic outcome of older adults hospitalized for the treatment of HF or infection, indicating that RDW is a stable and reliable parameter in these common diseases. Geriatr Gerontol Int 2019; 19: 988–992.

show abstract

Red blood cell distribution width as a novel marker for predicting bleeding after endoscopic resection for early gastric cancer

et al. 2022

View full text Add to dashboard Cite

Objectives Endoscopic resection (ER) is a minimally invasive treatment for early gastric cancer (EGC); however, there is a high occurrence of bleeding. This study aimed to clarify the significance of red blood cell distribution width (RDW) as a predictive risk factor for bleeding after ER for EGC. Methods We conducted a retrospective study based on data for patients who underwent ER for EGC from 2019 to 2021. This study included 79 lesions in 54 patients who underwent ER for EGC. The primary outcome was the association between RDW before ER and bleeding within 28 days of treatment. Receiver operating characteristic (ROC) curves were constructed, wherein areas under the curve (AUCs) and 95% confidence intervals were calculated to compare the discriminatory power of RDW for predicting bleeding. Results Endoscopic submucosal dissection was used as the resection method for 73 lesions, whereas endoscopic mucosal resection was used for six lesions. En bloc resection was performed in all cases. There were no cases of perforation; however, bleeding after ER occurred in five cases (9.3%). ROC curve analysis of bleeding after ER showed that the AUC was 0.843 with a good diagnostic performance. When the cut‐off value of RDW was set at 14.4%, sensitivity and specificity were 80% and 85.7%, respectively. There was a bleeding rate of 36.4% (4/11) at an RDW of ≥14.4%, which was significantly higher than that of 2.3% (1/43) at an RDW of <14.4%. Conclusion RDW can be a predictor of bleeding risk after ER for EGC.

show abstract

Early in-hospital variation of red blood cell distribution width predicts mortality in patients with acute heart failure

Cited by 25 publications

References 20 publications

The diagnostic and prognostic value of red cell distribution width in cardiovascular disease; current status and prospective

The diagnostic and prognostic value of red cell distribution width in cardiovascular disease; current status and prospective

Prognostic significance of red cell distribution width in hospitalized older patients with heart failure or infection

Red blood cell distribution width as a novel marker for predicting bleeding after endoscopic resection for early gastric cancer

Contact Info

Product

Resources

About