Early improvements in vision after fractionated stereotactic radiotherapy for primary optic nerve sheath meningioma

Baumert, Brigitta G.; Villà, Salvador; Studer, Gabriela; Mirimanoff, René-Olivier; Davis, J. Bernard; Landau, Klara; Ducrey, N; Arruga, J; Lambin, Philippe; Pica, Alessia

doi:10.1016/j.radonc.2004.04.008

Cited by 110 publications

(49 citation statements)

References 18 publications

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“…Baumert et al [5] refer to a group of 23 patients in whom stabilisation or improvement of vision was improved in 95% of cases during the observation period (median 20 months). Improvement of vision was determined already within the course of one to three months following stereotactic fractionated radiotherapy.…”

Section: Discussionmentioning

confidence: 99%

Orbital optic nerve sheath meningioma

Furdová

Babál

Kobzová

2018

CSO

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Section: Discussionmentioning

confidence: 99%

Orbital optic nerve sheath meningioma

Furdová

Babál

Kobzová

2018

CSO

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“…Nine patients showed improved visual fields. Baumert et al from Switzerland treated 23 patients with tumor progression using FSRT with 50.4 Gy delivered over six weeks [21]. With a median follow-up of 20 months, 16 of their patients experienced improvement in vision, five had stable vision, and one got worse.…”

Section: Discussionmentioning

confidence: 99%

Staged image guided robotic radiosurgery for optic nerve sheath meningiomas

Romanelli

Bianchi

Muacevic³

et al. 2011

Computer Aided Surgery

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Objective: Optic nerve sheath meningiomas (ONSMs) represent the most challenging lesions involving the optic pathways: Microsurgery is not indicated and classical single-stage radiosurgery appears to be too risky due to the expected destruction of the common blood supply with consequent loss of vision. Staged radiosurgery might be one treatment option because it exploits the ability of normal tissues to repair sub-lethal radiation-induced damage, offering a chance to control tumor growth while sparing function. Staged robotic radiosurgery was offered to 5 patients harboring ONSMs with the aim of sparing vision while achieving local growth control. Patients and Methods: Five patients with ONSM presenting with visual field deficits and loss of visual acuity were treated with staged CyberKnife radiosurgery, receiving 20 Gy in 4 stages (5 Gy per stage). Treatment planning was based on contrast-enhanced thin-slice CT (1.25 mm thickness for the first three cases, 0.5 mm for the last two) and volumetric MR imaging (1.5 T for the first three cases, 3 T for the last two). An interval of 24 hours was strictly observed between stages. Visual acuity and visual fields were assessed in all patients immediately prior to treatment and at intervals of 6 months thereafter. Follow-up MRIs were performed every 6 months for 2 years, then once per year. Results: The entire procedure, inclusive of imaging, treatment planning and treatment delivery, was performed in 5 days. Irradiation required approximately 45 min per stage. Mean tumor volume was 2.94 cc (range: 0.8-6.4 cc). Treatment was well tolerated in all patients. Follow-up ranged from 36 to 74 months. Local growth control was achieved in all patients. Restoration of normal vision was experienced by 4 patients 6 to 12 months after the treatment. One patient, who was also affected by diabetic retinopathy, showed a modest improvement after 6 months, remaining stable thereafter. Conclusion: Staged CyberKnife radiosurgery provides a fast and well-tolerated non-invasive treatment with excellent visual outcomes. If these preliminary results are confirmed by larger series, staged radiosurgery could be proposed as a first-line treatment for ONSM.

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“…33,43,57,59,74,78,85 However, only recently has excellent functional outcome matched with very low toxicity been enabled by modern RT techniques. This holds even truer as RT candidates represent an unfavorable group of patients suffering from ''clinically active'' disease, characterized by progressive vision impairment.…”

Section: Discussionmentioning

confidence: 99%

“…The characteristics of these studies and the outcome are given in Table 1, including the most recent multi-institutional study by Baumert et al, 78 and smaller studies of Richards et al, 79 Landert et al, 80 a report of a case by Paridaens et al, 81 and the most recent report by Sitathanee et al, 82 all published later on. Liu et al, 58 Becker et al, 59 as well as Pitz et al 57 and Baumert et al 78 reported on pONSM exclusively/separately. Turbin et al 43 provided the longest follow-up, reporting on 18 pONSM of a total of 64 ONSM patients, without specifying the details on the outcome for pONSM.…”

Section: Treatmentmentioning

confidence: 99%

“…59 This is likely adequate follow-up for the detection of RT-induced toxicity on optic pathways. The recent study of Baumert et al 78 reported on 22 patients with pONSM treated with SFRT in 4 European institutions. This study reconfirmed that SFRT offers excellent results (95% improved and stable visual outcome) observed after a median of 20 months (range, 1-68 months).…”

Section: Treatmentmentioning

confidence: 99%

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Primary optic nerve sheath meningioma

Jeremić

Pitz

2007

Cancer

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Biotechnological production of weak organic acids such as succinic acid is most economically advantageous when carried out at low pH. Among naturally occurring microorganisms, several bacterial strains are known to produce considerable amounts of succinic acid under anaerobic conditions but they are inefficient in performing the low‐pH fermentation due to their physiological properties. We have proposed therefore a new strategy for construction of an aerobic eukaryotic producer on the basis of the yeast Yarrowia lipolytica with a deletion in the gene coding one of succinate dehydrogenase subunits. Firstly, an original in vitro mutagenesis‐based approach was proposed to construct strains with Ts mutations in the Y. lipolytica SDH1 gene. These mutants were used to optimize the composition of the media for selection of transformants with the deletion in the Y. lipolytica SDH2 gene. Surprisingly, the defects of each succinate dehydrogenase subunit prevented the growth on glucose but the mutant strains grew on glycerol and produced succinate in the presence of the buffering agent CaCO3. Subsequent selection of the strain with deleted SDH2 gene for increased viability allowed us to obtain a strain capable of accumulating succinate at the level of more than 45 g L−1 in shaking flasks with buffering and more than 17 g L−1 without buffering. The possible effect of the mutations on the utilization of different substrates and perspectives of constructing an industrial producer is discussed. Biotechnol. Bioeng. 2010;107:673–682. © 2010 Wiley Periodicals, Inc.

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Early improvements in vision after fractionated stereotactic radiotherapy for primary optic nerve sheath meningioma

Cited by 110 publications

References 18 publications

Orbital optic nerve sheath meningioma

Orbital optic nerve sheath meningioma

Staged image guided robotic radiosurgery for optic nerve sheath meningiomas

Primary optic nerve sheath meningioma

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