Early Implant Survival in Posterior Maxilla With or Without β-Tricalcium Phosphate Sinus Floor Graft

Uçkan, Sina; Deniz, K.; Dayangac, Emre; Araz, Kenan; Ozdemır, B. Handan

doi:10.1016/j.joms.2009.08.028

Cited by 31 publications

(35 citation statements)

References 10 publications

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“…Regarding the biomaterial, we used β-TCP as a carrier and scaffold because it is well known to have osteoinductive or osteogenic abilities and is widely used as bone prosthetic material [Uckan et al, 2010;Zhang et al, 2011]. Our histological data, however, showed that β-TCP alone induced no new bone formation and remained in the lifted space even after 8 weeks of observation ( fig.…”

Section: Discussionmentioning

confidence: 88%

Efficient Bone Formation in a Swine Socket Lift Model Using Escherichia coli-Derived Recombinant Human Bone Morphogenetic Protein-2 Adsorbed in β-Tricalcium Phosphate

Ono

Sonoyama

Yamamoto

et al. 2014

Cells Tissues Organs

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Several preclinical studies have shown that Escherichia coli-derived bone morphogenetic protein-2 (E-BMP-2) is as effective as mammalian cell-derived bone morphogenetic protein-2 (C-BMP-2) in the treatment of bone defects. However, further investigation of the effectiveness and determination of the optimal dosage of E-BMP-2 in large animals are still necessary before its full application in humans. This study investigated the efficiency of different concentrations of E-BMP-2 adsorbed in β-TCP for bone augmentation and osseointegration of immediate dental implants in a swine socket lift model. Following exposure of the maxillary sinus lateral wall, a 3.4-mm (diameter) cavity was drilled and filled with 0.1 g of β-TCP containing different doses of E-BMP-2 (0, 10, 30, or 100 μg/site) to lift the Schneiderian membrane. A dental implant was then immediately inserted. Bone-to-implant contact (BIC) and bone density (BD) examined via histological analysis were used as parameters to assess E-BMP-2 efficiency in bone formation. The implant stability quotient (ISQ) was measured using Osstell to determine the effect of E-BMP-2/β-TCP on implant stability. After 8 weeks, the groups that received 30 and 100 μg of E-BMP-2 showed substantial new bone formation in the elevated space, while no bone formation was observed with β-TCP alone. Accordingly, BIC and BD presented a dose-dependent response to increasing doses of E-BMP-2. However, there was no increase in implant stability with E-BMP-2 treatment. In conclusion, the E-BMP-2/β-TCP combination was efficient in bone formation and osseointegration of dental implants in a socket lift model in mini-pigs.

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Section: Discussionmentioning

confidence: 88%

Efficient Bone Formation in a Swine Socket Lift Model Using Escherichia coli-Derived Recombinant Human Bone Morphogenetic Protein-2 Adsorbed in β-Tricalcium Phosphate

Ono

Sonoyama

Yamamoto

et al. 2014

Cells Tissues Organs

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“…It has been extensively used for repairing bone defect in craniofacial and maxillary region [3,4]. As a scaffold material for bone regeneration, b-TCP possesses good biocompatibility for cell attachment, differentiation in vitro and bone formation in vivo.…”

Section: Introductionmentioning

confidence: 99%

The healing of critical-size calvarial bone defects in rat with rhPDGF-BB, BMSCs, and β-TCP scaffolds

Zhang

et al. 2012

J Mater Sci: Mater Med

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Platelet-derived growth factor-BB (PDGF-BB) plays important roles in regenerating damaged tissue. In this study we investigated the effects of a tissue-engineered bone combined with recombinant human PDGF-BB (rhPDGF-BB), bone marrow stem cells (BMSCs) and β-tricalcium phosphate (β-TCP) to repair critical-size calvarial bone defects in rat. Proliferation and osteogenic differentiation of BMSCs treated with different concentration rhPDGF-BB (0, 10, and 50 ng/ml) was evaluated by MTT, alkaline phosphatase (ALP) activity, alizarin red staining and real-time quantitative PCR (RT-qPCR) analysis of osteogenic gene. BMSCs were then combined with rhPDGF-BB-loaded β-TCP and transplanted into 5 mm calvarial bone defects. The new bone formation and mineralization was evaluated by micro-computerized tomography (Micro-CT) and histological analysis at week 8 after operation. It was observed that the proliferation of BMSCs treated with rhPDGF-BB was enhanced with a time- and dose- dependent manner. There were increased ALP activity, mineralized deposition and elevated mRNA levels of osteogenic gene for BMSCs treated with rhPDGF-BB, particularly in the 50 ng/ml group. Histological analysis showed new bone formation and mineralization in the rhPDGF-BB/BMSCs/β-TCP group was significantly higher than BMSCs/β-TCP, rhPDGF-BB/β-TCP, and β-TCP alone group (P < 0.05). In conclusion, rhPDGF-BB/BMSCs/β-TCP is a promising tissue-engineered bone for craniofacial bone regeneration.

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“…Le β-TCP a de multiples utilisations en chirurgie orale (comblement sinusien, réparation de défauts osseux en implantologie et en parodontologie, etc. [20][21][22]). …”

Section: Matériaux De Comblement Osseux D'origine Synthétiqueunclassified

Intérêt de l’oxygénothérapie hyperbare dans l’optimisation de la cicatrisation osseuse en odontostomatologie

Gunepin

Derache

Pêcheur

et al. 2013

Med Buccale Chir Buccale

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Résumé -En odontostomatologie, face à une perte de substance osseuse dont le comblement ne peut intervenir spontanément du fait des seules capacités physiologiques du patient (défaut osseux de taille critique), le praticien peut avoir recours à de nombreux matériaux de comblement osseux. Actuellement, le matériau de référence reste l'os du patient (greffe autogène). Cependant, pour des raisons liées parfois au manque de disponibilité de cet os et/ou à la morbidité potentielle accompagnant la création d'un second site opératoire, le praticien peut avoir recours à de l'os allogène (provenant d'un autre patient), de l'os xénogène (d'origine animal) ou à des matériaux de substitution osseuse d'origine naturelle ou synthétique. La correction de ces défauts osseux pouvant être essentielle en odontostomatologie (prévention de la survenue de fracture, possibilité d'entreprendre ultérieurement des traitements implantaires et prothétiques et préservation de l'esthétique), de nombreux auteurs ont étudié différentes techniques visant à optimiser le processus de cicatrisation osseuse. Dès les années 1960, l'oxygénothérapie hyperbare ou OHB a été proposée comme traitement adjuvant de la cicatrisation osseuse. L'OHB consiste en l'administration d'oxygène pur à un patient à une pression supérieure à celle du niveau de la mer. Actuellement il n'existe aucune preuve de l'efficacité ou de l'inefficacité de l'OHB sur la cicatrisation osseuse. Ceci s'explique par le manque de connaissance des mécanismes exacts de l'action de l'OHB sur le tissu osseux et sur l'absence de larges essais cliniques contrôlés randomisés. L'analyse de la littérature met cependant en exergue le fait que si l'OHB ne doit pas être utilisée systématiquement, son recours peut être envisagé en fonction de la lésion, du patient, du type de greffe réalisé et/ou du type de substitut osseux utilisé.Abstract -Interest of hyperbaric oxygen therapy in the optimization of bone healing in odontostomatology.

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Early Implant Survival in Posterior Maxilla With or Without β-Tricalcium Phosphate Sinus Floor Graft

Cited by 31 publications

References 10 publications

Efficient Bone Formation in a Swine Socket Lift Model Using <b><i>Escherichia coli-</i></b>Derived Recombinant Human Bone Morphogenetic Protein-2 Adsorbed in β-Tricalcium Phosphate

Efficient Bone Formation in a Swine Socket Lift Model Using <b><i>Escherichia coli-</i></b>Derived Recombinant Human Bone Morphogenetic Protein-2 Adsorbed in β-Tricalcium Phosphate

The healing of critical-size calvarial bone defects in rat with rhPDGF-BB, BMSCs, and β-TCP scaffolds

Intérêt de l’oxygénothérapie hyperbare dans l’optimisation de la cicatrisation osseuse en odontostomatologie

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