Early Immunological Influences

Holt, Patrick G.; Naspitz, Charles K.; Warner, John O.

doi:10.1159/000081440

Cited by 20 publications

(11 citation statements)

References 130 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is also not clear how maternal exposures during pregnancy affect asthma, hay fever and eczema manifestation in the offspring. One possibility is that maternal immune responses to farm exposures (through cytokine production) may prime the developing foetal immune system [25]. Alternatively, foetal priming to environmental antigens in utero may play a role [26].…”

Section: Discussionmentioning

confidence: 99%

Farm exposure in utero may protect against asthma, hay fever and eczema

Douwes

Cheng²,

Travier³

et al. 2008

European Respiratory Journal

184

136

View full text Add to dashboard Cite

The aim of the present study was to assess which factors contribute to the lower prevalence of allergic diseases in farmers' children, and the importance of timing of exposure.In a cross-sectional questionnaire survey, asthma symptoms, hay fever and eczema were assessed, as well as current, early and prenatal farm-related exposures in 1,333 farmers' children and 566 reference children aged 5-17 yrs.Farmers' children had a lower incidence of asthma symptoms and eczema. Current and maternal exposure during pregnancy to animals and/or grain and hay reduced the risk of asthma symptoms, hay fever and eczema. The exposure-response association for maternal exposure was nonlinear for most outcomes. After mutual adjustment, the effects of prenatal exposure remained unchanged whereas current exposure remained protective only for asthma medication, asthma ever and hay fever. Exposure during the first 2 yrs was not associated with symptoms, after controlling for prenatal exposure. A combination of prenatal and current exposure was most strongly associated with wheeze (odds ratio ( Prenatal exposure may contribute to the low prevalence of asthma, hay fever and eczema in farmers' children, but continued exposure may be required to maintain optimal protection.

show abstract

Section: Discussionmentioning

confidence: 99%

Farm exposure in utero may protect against asthma, hay fever and eczema

Douwes

Cheng²,

Travier³

et al. 2008

European Respiratory Journal

184

136

View full text Add to dashboard Cite

show abstract

“…2,5-7 As a consequence, an early intervention able to reduce this ''allergic march'' or ''allergic cosensitization,'' which is also referred to as ''collateral priming,'' has become an aim in these children. [8][9][10] Such an early intervention can be obtained by using allergen-specific immunotherapy. For instance, subcutaneous immunotherapy and sublingual immunotherapy initiated at the age of 6 years in patients with respiratory allergy displays a preventive effect on both the occurrence of new sensitizations [11][12][13][14][15] and asthma onset.…”

mentioning

confidence: 99%

Specific epicutaneous immunotherapy prevents sensitization to new allergens in a murine model

Mondoulet

Dioszeghy

Puteaux

et al. 2015

Journal of Allergy and Clinical Immunology

View full text Add to dashboard Cite

“…1,2 Also, a number of mechanisms have been implicated for the prenatal development of asthma and atopic diseases, and potential strategies to reverse the process are discussed. [3][4][5] For atopic sensitization, a protective effect by prenatal exposure to a farm environment has been suggested: an inverse association of maternal exposure to animal sheds during pregnancy with atopic sensitization in the offspring at school age has been found in a survey. 6 The cross-sectional design of that study, the retrospective assessment of the exposure, and the time gap between exposure and outcome evaluation precluded the establishment of a causal relation.…”

mentioning

confidence: 99%