Early Immune Response Regulated by a Bone Marrow Mesenchymal Stem Cell Model of Multiple Trauma in Rats

Wen, Tianlin; Wang, Fei; Chen, Yunqiang; Sun, Tiansheng

doi:10.2217/imt-2018-0010

Cited by 1 publication

(1 citation statement)

References 36 publications

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“…Transplanted stem cells not only provide cell sources for regeneration but also regulate inflammatory and immune responses. 67 , 68 Immunomodulation is an important function of stem cells that play an inhibitive role as neuroinflammation in an active state. Stem cell treatment suppresses neuroinflammation through different mechanisms, including (i) direct roles.…”

Section: Transplanted Bmmscs Inhibit Neuroinflammationmentioning

confidence: 99%

Functional Mechanism of Bone Marrow-Derived Mesenchymal Stem Cells in the Treatment of Animal Models with Alzheimer’s Disease: Inhibition of Neuroinflammation

Qin¹,

Li²,

Wang³

2021

JIR

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The transplantation of bone marrow-derived mesenchymal stem cells (BMMSCs) alleviates neuropathology and improves cognitive deficits in animal models with Alzheimer’s disease. However, the underlying mechanisms remain to be determined. Available data demonstrate transplanted BMMSCs can inhibit neuroinflammation, which may be related to microglial M1/M2 polarization and is regulated by the secretion of autocrine and paracrine cytokines. BMMSCs also mitigate Aβ plaques and Tau tangles in the brain, which may be associated with the recruitment of peripheral blood monocytes and the subsequent comprehensive effects. The therapeutic effects of stem cells involve potential mechanisms such as immunomodulation, apoptosis, and proliferation. BMMSC-mediated functional reconstruction through dynamic remodeling develops a novel balance. Herein, present review recapitulates the molecular basis of BMMSC-assisted biological processes and summarizes the possible mechanisms related to the interaction between BMMSCs and microglia. The transplanted BMMSCs can suppress neuroinflammation that plays a key role in the pathogenesis of Alzheimer’s disease.

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Section: Transplanted Bmmscs Inhibit Neuroinflammationmentioning

confidence: 99%

Functional Mechanism of Bone Marrow-Derived Mesenchymal Stem Cells in the Treatment of Animal Models with Alzheimer’s Disease: Inhibition of Neuroinflammation

Qin¹,

Li²,

Wang³

2021

JIR

View full text Add to dashboard Cite

show abstract

Early Immune Response Regulated by a Bone Marrow Mesenchymal Stem Cell Model of Multiple Trauma in Rats

Abstract: BMSCs reduced the inflammatory response and were effective in immunomodulations during severe trauma.

Cited by 1 publication

References 36 publications

Functional Mechanism of Bone Marrow-Derived Mesenchymal Stem Cells in the Treatment of Animal Models with Alzheimer’s Disease: Inhibition of Neuroinflammation

Functional Mechanism of Bone Marrow-Derived Mesenchymal Stem Cells in the Treatment of Animal Models with Alzheimer’s Disease: Inhibition of Neuroinflammation

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