Early identification of the risk for free radical-related diseases in preterm newborns

Perrone, Serafina; Tataranno, Maria Luisa; Negro, Simona; Longini, Mariangela; Marzocchi, Barbara; Proietti, Fabrizio; Iacoponi, Francesca; Capitani, Serena; Buonocore, Giuseppe

doi:10.1016/j.earlhumdev.2010.03.008

Cited by 112 publications

(87 citation statements)

References 28 publications

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“…The presented study demonstrated that prooxidative activity continues to grow in neonatal blood for at least three days after birth. These results are similar to those of Perrone et al [10]. The presence of oxidative stress markers may also be demonstrated in the umbilical cord blood, indicating the risk of foetal exposure to ROS during intrauterine life.…”

Section: Discussionsupporting

confidence: 91%

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Oxidative stress and total antioxidant status in term newborns and their mothers

Wilińska¹,

Borszewska−Kornacka²,

Niemiec³

et al. 2015

Ann Agric Environ Med.

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The peripartum period and delivery are considered critical for maintaining a balance between the production of free oxygen radicals and functional incompetence of the antioxidant system of a foetus and a neonate. Objective. The aim of the study was to evaluate the oxidoreductive state of mothers and their newborns immediately after delivery and in the first few days after birth. Method. Eighty-five mothers and their healthy, term newborns were included into the prospective study. Total antioxidant capacity (TAC) and thiobarbituric acid reactive substances (TBARS) in maternal placenta and milk, as well as blood and urine of the neonates on the first and third day after birth, were examined. Results. Elevated levels of TBARS were found in maternal placenta and neonatal blood on the third day after birth, but low concentrations were observed in maternal milk. On the contrary, total antioxidant status (TAS) showed a declining tendency in neonatal blood and an increasing tendency in breast milk. Markers of oxidative stress and antioxidant capacity were independent of the mode of delivery. Conclusions. Values of oxidative stress markers in mothers and newborns immediately after birth were elevated and increased further during the first few days of neonatal life. Breast milk was the only nutritional substance with high antioxidant activity. At the same time, TBARS levels in breast milk decreased, which might indicate its protective role in reducing oxidative stress in newborns.

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Section: Discussionsupporting

confidence: 91%

“…A study by Perrone et al demonstrated a strong correlation between iron-binding protein concentration and the prevalence of the so-called free radical-related diseases in newborns, i.e. intraventricular haemorrhage, periventricular leucomalacia, patent ductus arteriosus, retinopathy of prematurity and bronchopulmonary dysplasia [10].…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress and total antioxidant status in term newborns and their mothers

Wilińska¹,

Borszewska−Kornacka²,

Niemiec³

et al. 2015

Ann Agric Environ Med.

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“…Increased cord blood levels of hydroperoxides, oxidized proteins, and nonprotein-bound iron correlated with the risk of free radical disease, including BPD, intraventricular hemorrhage, necrotizing enterocolitis, and retinopathy of prematurity (ROP). Of these biomarkers, nonprotein-bound iron, which enters the Fenton reaction to produce hydroxyl radical, was the best predictor of the disease (93). Postnatal exposures also contribute to an increased oxidative stress, with evidence that elevated urine 8-hydroxydeoxyguanosine (8-OHdG), plasma 8-isoprostane, and protein carbonylation levels during the first week are all associated with a greater risk of BPD (14, 67).…”

Section: Oxidative Stress In Bpdmentioning

confidence: 99%

Developmental Regulation of Antioxidant Enzymes and Their Impact on Neonatal Lung Disease

Berkelhamer

Farrow

2014

Antioxidants & Redox Signaling

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Significance: Deficient antioxidant defenses and compromised ability to respond to oxidative stress burden the immature lung. Routine neonatal therapies can cause increased oxidative stress with subsequent injury to the premature lung. Novel therapeutic approaches to protect the premature lung are greatly needed. Recent Advances: Live cell imaging with targeted redox probes allows for the measurement of subcellular oxidative stress and for comparisons of oxidative stress across development. Comprehension of subcellular and cell-typespecific responses to oxidative stress may influence the targeting of future antioxidant therapies. Critical Issues: Challenges remain in identifying the optimal cellular targets, degree of enzyme activity, and appropriate antioxidant therapy. Further, the efficacy of delivering exogenous antioxidants to specific cell types or subcellular compartments remains under investigation. Treatment with a nonselective antioxidant could unintentionally compromise cellular function or impact cellular defense mechanisms and homeostasis. Future Directions: Genetic and/or biomarker screening may identify infants at the greatest risk for oxidative lung injury and guide the use of more selective antioxidant therapies. Novel approaches to the delivery of antioxidant enzymes may allow cell type-or cellular organelle-specific therapy. Improved comprehension of the antioxidant enzyme regulation across cell type, cell compartment, gender, and developmental stage is critical to the design and optimization of therapy.

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“…Preterm birth is associated with increased generation of reactive oxygen species (ROS), which places these infants in high risk for injury (Davis & Auten, 2010). In fact, a recent study identified an increase in the oxidative stress marker non-protein bound iron (NPBI) in the cord blood of 168 preterm newborns of gestational age 24-32 weeks (Perrone et al, 2010), suggesting that early identification of neonates at-risk is possible. The impact of environmental oxidants in the etiology of autism is associated with brain region-specific changes in oxidative stress markers, such as 3-nitrotyrosine (3-NT) and neurotrophin-3 (NT-3), in ASD (Sajdel-Sulkowska et al, 2008;Sajdel-Sulkowska et al, 2011).…”

Section: Oxidative Stress and Prematuritymentioning

confidence: 99%

Perinatal Immune Activation and Risk of Autism

Theoharides¹,

Angelidou²,

Alysandratos³

et al. 2011

Autism - A Neurodevelopmental Journey From Genes to Behaviour

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Early identification of the risk for free radical-related diseases in preterm newborns

Cited by 112 publications

References 28 publications

Oxidative stress and total antioxidant status in term newborns and their mothers

Oxidative stress and total antioxidant status in term newborns and their mothers

Developmental Regulation of Antioxidant Enzymes and Their Impact on Neonatal Lung Disease

Perinatal Immune Activation and Risk of Autism

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