Early identification of stimulant treatment responders, partial responders and non-responders using objective measures in children and adolescents with hyperkinetic disorder

Vogt, Carsten; Williams, Tim

doi:10.1111/j.1475-3588.2010.00593.x

Cited by 40 publications

(40 citation statements)

References 21 publications

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“…Because ADHD rating forms are vulnerable to placebo (Waschbusch et al 2009) and source (Gomez et al 2003) effects, the inclusion of objective test measures in clinical trials has been recommended by several authors (Teicher et al 2008;Waschbusch et al 2009;Sumner et al 2010). Computer-based continuous performance tests (cb-CPT) are a large family of laboratory tests measuring attention; they are administered in a diversity of forms.…”

Section: Introductionmentioning

confidence: 99%

Clinical Gains from Including Both Dextroamphetamine and Methylphenidate in Stimulant Trials

Ramtvedt

Røinås²,

Aabech³

et al. 2013

Journal of Child and Adolescent Psychopharmacology

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Section: Introductionmentioning

confidence: 99%

Clinical Gains from Including Both Dextroamphetamine and Methylphenidate in Stimulant Trials

Ramtvedt

Røinås²,

Aabech³

et al. 2013

Journal of Child and Adolescent Psychopharmacology

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“…Typically, a CPT is a computer based programme which involves rapid presentation of visual or auditory stimuli where participants are asked to respond when a given target occurs but remain passive to non-targets. CPTs are a popular adjunct in the assessment of attention [24,25].…”

Section: A Snappyapp: Continuous Performance Testmentioning

confidence: 99%

From Snappy App to Screens in the Wild: Gamifying an Attention Deficit Hyperactivity Disorder Continuous Performance Test for Public Engagement and Awareness

Craven

Young

Simons

et al. 2014

2014 International Conference on Interactive Technologies and Games

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Abstract-Attention Deficit Hyperactivity Disorder (ADHD) is a neurodevelopmental condition that is characterised by three core behaviours: inattention, hyperactivity and impulsivity. It is typically thought that around 3-5% of school aged children have ADHD, with lifetime persistence for the majority.A psychometric Continuous Performance Test (CPT) had recently been incorporated into an interactive smartphone application (App), SnappyApp, to allow the measurement of the three ADHD symptom domains. SnappyApp presents a sequence of letters of the alphabet in a pseudo-random manner with responses via the device's touch screen. Following a pilot test in the general population where the CPT showed sensitivity to ADHD-related symptoms (self-reported impulsive behaviour related to CPT measures), a new project was begun to convert the App into a game Attention Grabber based on the functionality of the test, focussing on the attention and impulsivity domains.The Screens in the Wild (SITW) platform is in the process of being employed for public engagement in awareness about ADHD through interactive technology. SITW has deployed a network of four public touch-screens in urban places. Each of the four nodes has a large (46 inch) display, a camera, a microphone and a speaker. The SnappyApp web-app was translated for presentation on to the SITW platform. The browser-based App was redesigned, with the input of a commercial graphics design company, based on an initial proof-of-concept whereby the original App was reprogrammed to present sequences of graphical objects (fruit) and to introduce further engagement features including animations. A shortened video about Adult ADHD and a brief questionnaire were incorporated to form a stand-alone edutainment package.The earlier design and user testing of SnappyApp is briefly described and details are then provided of the process of gamification to produce Attention Grabber. An evaluation process is described whereby awareness of ADHD and its related symptoms are to be probed. In general, finding out whether and how people engage with interactive screen technology can help in the design of future public engagement and health promotion activities. Ethical considerations are discussed, since public access to this kind of game could potentially raise health anxiety related to self-interpretation of game performance. This risk is balanced with the need to provide health information.

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“…More recently, psychometric tests are used in the assessment process to provide objective measures of patient's symptoms. Such measures of cognitive function also offer the potential to objectively measure response to medication, and could potentially hasten the process of treatment optimisation [10].…”

mentioning

confidence: 99%

“…This CPT is preferable to using the X-CPT in adults where ceiling effects are often found [2]. These kinds of objective tests are commonly used to assess attention [10] and are considered to be the most sensitive assessment of medication effects [12]. Studies have shown a clear separation on CPTs between people with ADHD and controls, with ADHD participants showing poorer performance on measures of attention and impulsivity [13,14].…”

mentioning

confidence: 99%

“…Some objective measures of attention now incorporate motor activity measures using actigraphs [15] or infra-red motion analysis [10,16,17] to give a fuller picture of the range of symptoms associated with ADHD. Such cognitive tests with motion analysis can reliably differentiate children [10,17] and adults with ADHD [3] from controls and can provide a good measure of treatment response, with the potential for speeding up treatment optimisation [10].…”

mentioning

confidence: 99%

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Snappy App: A Mobile Continuous Performance Test with Physical Activity Measurement for Assessing Attention Deficit Hyperactivity Disorder

Young

Craven

Groom

et al. 2014

Human-Computer Interaction. Applications and Services

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Abstract.A Continuous Performance Test (CPT) was incorporated into a smartphone application (App) to measure three symptom domains associated with Attention Deficit Hyperactivity Disorder (ADHD); attention, impulsivity and hyperactivity. The App was pilot tested on 11 healthy adults over three testing sessions. No differences in performance were found between testing sessions suggesting good test consistency. A decrement in performance over time was only found for one measure of attention and on one testing session. The CPT showed some sensitivity to ADHD-related symptoms where self-reported impulsive behaviour was related to the CPT measures of impulsivity and activity. User acceptability was good although some design improvements were suggested. Further pilot testing of the App in a clinical population is needed.

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Early identification of stimulant treatment responders, partial responders and non-responders using objective measures in children and adolescents with hyperkinetic disorder

Cited by 40 publications

References 21 publications

Clinical Gains from Including Both Dextroamphetamine and Methylphenidate in Stimulant Trials

Clinical Gains from Including Both Dextroamphetamine and Methylphenidate in Stimulant Trials

From Snappy App to Screens in the Wild: Gamifying an Attention Deficit Hyperactivity Disorder Continuous Performance Test for Public Engagement and Awareness

Snappy App: A Mobile Continuous Performance Test with Physical Activity Measurement for Assessing Attention Deficit Hyperactivity Disorder

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