Early human fetal lung atlas reveals the temporal dynamics of epithelial cell plasticity
Amy Wong,
Henry Quach*,
Spencer Farrell*
et al.
Abstract:While animal models have provided key insights into conserved mechanisms of how the lung forms during development, human-specific developmental mechanisms are not always captured. To fully appreciate how developmental defects and disease states alter the function of the lungs, studies in human lung models are important. Here, we sequenced >150,000 single single-cells from 19 healthy human fetal lung tissues from gestational weeks 10-19 and identified at least 58 unique cell types/states contributing to the … Show more
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