Early growth response transcription factors and the modulation of immune response

Gómez‐Martín, Diana; Díaz-Zamudio, Mariana; Galindo-Campos, Miguel; Alcocer‐Varela, Jorge

doi:10.1016/j.autrev.2009.12.006

Cited by 62 publications

(57 citation statements)

References 25 publications

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“…We also observed NPY induction of Egr-1 gene, a transcription factor involved in cell proliferation and in the regulation of apoptosis [12,13]. It is thus assumed that NPY released from sympathetic nerve terminal stimulates proliferation of SVC, resulting in hyperplasia of the BAT, which occurs in response to physiological stimuli such as cold exposure [20].…”

Section: Discussionmentioning

confidence: 61%

Neuropeptide Y activates phosphorylation of ERK and STAT3 in stromal vascular cells from brown adipose tissue, but fails to affect thermogenic function of brown adipocytes

et al. 2012

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Section: Discussionmentioning

confidence: 61%

Neuropeptide Y activates phosphorylation of ERK and STAT3 in stromal vascular cells from brown adipose tissue, but fails to affect thermogenic function of brown adipocytes

et al. 2012

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“…EGR3 belongs to the EGR family of transcription factors that can regulate a wide range of biological processes (Fang et al, 2013), including central nervous system development, muscle stretch receptor function, angiogenesis, immunity, and cancer (Li et al, 2007;Gomez-Martin et al, 2010;Perez-Cadahia et al, 2011;Baron et al, 2015). Although evidence of EGR3 playing certain roles in cancer remains scant, it has been shown that EGR3 was relevant to the breast cancer cells, gastric cancer and prostate cancer cells (Suzuki et al, 2007;Liao et al, 2013;Pio et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Involvement of microRNA-718, a new regulator of EGR3, in regulation of malignant phenotype of HCC cells

Wang¹,

Chen

et al. 2017

J. Zhejiang Univ. Sci. B

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Abstract:Objective: Hepatocellular carcinoma (HCC) is still one of the most common death-related malignancies worldwide. Because the way onset and progression are hidden most, HCC diagnoses are made at an advanced stage, when they are unsuitable for surgical resection. MicroRNAs are a class of small non-coding RNAs, participating in many aspects of cancers. In this study, we tried to establish the role of microRNA-718 (miR-718) in the malignant phenotype of HCC cells and its possible role in HCC diagnosis. Methods: Here we first used a methylthiazolyldiphenyltetrazolium bromide (MTT) assay, Transwell migration and invasion assays, and colony formation assay to evaluate the impact of miR-718 on the malignant phenotypes of HCC cells. Then, we used bioinformatic methods to predict the target gene of miR-718 and used green fluorescence protein (GFP) reporter assay, Western blot, and quantitative real-time polymerase chain reaction (qRT-PCR) to validate the regulation relationship. Finally, we determined the role of the target gene in the HCC phenotype. Results: We found that the expression of miR-718 was significantly reduced in various HCC cell lines and HCC tissues. Re-expression of miR-718 significantly reduced the cellular viability and colony formation ability as well as inhibited the migration and invasion abilities of HCC cell lines. Early growth response protein 3 (EGR3) is a direct target of miR-718 and is negatively regulated by miR-718. EGR3 could increase the viability and proliferation of HCC cells, and promot the migration and invasion of HCC cells. Conclusions: miR-718 acts as a tumor suppressive microRNA in HCC via regulating the expression of EGR3, which may provide a new diagnostic marker and treatment target for HCC.

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“…The current study demonstrated that EGR-1 and Myc were important TFs modulating upregulated DEGs, while ATF5 and SP1:SP3 were critical TFs for downregulated DEGs. EGR-1 has been identified to be an important TF and a tumor suppressor gene in addition (35). EGR-1 has been observed to be involved in thrombus formation and the inflammatory pathogenesis of AAA (36).…”

Section: Discussionmentioning

confidence: 99%

A comprehensive analysis of differentially expressed genes and pathways in abdominal aortic aneurysm

Yuan

Liang

Zhang

2015

Molecular Medicine Reports

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Abstract. The current study aimed to investigate the molecular mechanism underlying abdominal aortic aneurysm (AAA) via various bioinformatics techniques. Gene expression profiling analysis of differentially expressed genes (DEGs) between AAA samples and normal controls was conducted. The Database for Annotation, Visualization and Integrated Discovery tool was utilized to perform Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes analyses for DEGs and clusters from the protein-protein interaction (PPI) network, which was constructed using the Search Tool for the Retrieval of Interacting Genes. In addition, important transcription factors (TFs) that regulated DEGs were investigated. A total of 346 DEGs were identified between AAA samples and healthy controls. Additionally, four clusters were identified from the PPI network. Cluster 1 was associated with sensory perception of smell and the olfactory transduction subpathway. The most significant GO function terms for cluster 2 and 3 were response to virus and defense response, respectively. Cluster 4 was associated with mitochondria-associated functions and the oxidative phosphorylation subpathway. Early growth response-1 (EGR-1), Myc, activating transcription factor 5 (ATF5) and specificity protein (SP) 1:SP3 were identified to be critical TFs in this disease. The present study suggested that the olfactory transduction subpathway, mitochondria and oxidative phosphorylation pathways were involved in AAA, and TFs, such as EGR-1, Myc, ATF5 and SP1:SP3, may be potential candidate molecular targets for this disease.

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Early growth response transcription factors and the modulation of immune response

Cited by 62 publications

References 25 publications

Neuropeptide Y activates phosphorylation of ERK and STAT3 in stromal vascular cells from brown adipose tissue, but fails to affect thermogenic function of brown adipocytes

Neuropeptide Y activates phosphorylation of ERK and STAT3 in stromal vascular cells from brown adipose tissue, but fails to affect thermogenic function of brown adipocytes

Involvement of microRNA-718, a new regulator of EGR3, in regulation of malignant phenotype of HCC cells

A comprehensive analysis of differentially expressed genes and pathways in abdominal aortic aneurysm

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