Early Growth Response Protein 1 (Egr-1): Prototype of a Zinc-finger Family of Transcription Factors

Assessment of the gene expression profile of differentiated and dedifferentiated human fetal chondrocytes by microarray analysis

“…Wang et al (74) reported that the early growth response protein, Egr-1, is down-regulated in OA cartilage compared with normal cartilage. Egr-1, a zinc-finger transcription factor, has been shown to be important for cell proliferation, differentiation, and apoptosis, and is expressed in epiphyseal cartilage and AC during development (75,76). Interestingly, Egr-1 showed a wide expression pattern in normal cartilage, but was restricted to the clusters of clonal chondrocytes observed in OA cartilage (74).…”

Basic fibroblast growth factor transcriptional autoregulation requires EGR-1

“…Site C (GCGGGGGTG) is located in the promoter from 7165 to 7157 and site E (CGCCCCCGA) is located from 763 to 755 (Figure 2a). Each sequence is a 8/9 match with the consensus site Egr-1 GCGGGGGCG (Gashler and Sukhatme, 1995). Egr-1 is a growth factor and phorbol ester inducible transcription factor that is induced by new transcription and de novo synthesis (Maass et al, 1994;Gashler and Sukhatme, 1995).…”

“…Egr-1 is a zinc ®nger transcriptional factor (see Gashler and Sukhatme, 1995) which was also identi®ed as NGFI-A (Milbrandt, 1987), Zif268 (Lau and Nathans, 1987), Cef5 (Simmons et al, 1989), Krox24 (Lemaire et al, 1988) and Tis8 (Lim et al, 1987). Similar to c-Fos, Egr-1 expression is rapidly induced by mitogens such as platelet-derived growth factor (PDGF), FGF and epidermal growth factor (EGF) in ®broblasts (Sukhatme et al, 1987;Lau and Nathans, 1987;Lemaire et al, 1988), suggesting a possible role of Egr-1 in mediating bFGF autoregulation.…”

Introduction of DNA enzyme for Egr-1 into tubulointerstitial fibroblasts by electroporation reduced interstitial α-smooth muscle actin expression and fibrosis in unilateral ureteral obstruction (UUO) rats

“…Egr-1 is a zinc finger transcription factor encoding 80-82 kDa that bind to target DNA that interacts with a consensus GC rich region, GCG(T/G)GGGCG, to influence the transcription of a diverse set of genes. [13][14][15] Egr-1 has been implicated in the induced expression of several growth factors such as transforming growth factor-␤ (TGF-␤), 16 basic fibroblast growth factor (FGF), 17 platelet derived growth factor-A (PDGF-A) 18,19 and PDGF-B, 20 and adhesion molecule, such as intercellular adhesion molecule 1 (ICAM-1) 21 and CD44, 22 which was suggested to play an important role in renal interstitial inflammation and fibrosis. The induction of PDGF 4,23 and TGF-␤ 24,25 could contribute to myofibroblast transformation, proliferation and extracellular matrix accumulation that are the hallmarks of progressive interstitial fibrosis.…”