Early Growth and Neurologic Outcomes of Infants with Probable Congenital Zika Virus Syndrome

Silva, Antônio Augusto Moura da; Ganz, Jucelia Sousa Santos; Sousa, Patrícia da Silva; Doriqui, Maria Juliana R.; Ribeiro, Marizélia Rodrigues Costa; Branco, Maria dos Remédios Freitas Carvalho; Queiroz, Rejane Christine de Sousa; Pacheco, María; Costa, Flávia Regina Vieira da; Silva, Francelena de Sousa; Simões, Vanda Maria Ferreira; Pacheco, Marcos Antônio Barbosa; Lamy-Filho, Fernando; Lamy, Zeni Carvalho; Alves, Maria Teresa Seabra Soares de Britto e

doi:10.3201/eid2211.160956

Cited by 182 publications

(230 citation statements)

References 11 publications

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“…In addition some infants had other structural or functional abnormalities that might have brought them to medical attention regardless of their head size; however, these findings did not occur more frequently in infants with the smallest HCs. Congenital Zika virus infection without microcephaly at birth previously has been reported (8), as has postnatal development of microcephaly in infants presumed to be infected congenitally (9). However, this is the first series of infants with laboratory evidence of congenital Zika virus infection documented to have poor head growth with microcephaly developing after birth.…”

Section: Discussionmentioning

confidence: 69%

Description of 13 Infants Born During October 2015–January 2016 With Congenital Zika Virus Infection Without Microcephaly at Birth — Brazil

Linden¹,

Pessoa

Dobyns

et al. 2016

MMWR Morb. Mortal. Wkly. Rep.

380

228

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Section: Discussionmentioning

confidence: 69%

Description of 13 Infants Born During October 2015–January 2016 With Congenital Zika Virus Infection Without Microcephaly at Birth — Brazil

Linden¹,

Pessoa

Dobyns

et al. 2016

MMWR Morb. Mortal. Wkly. Rep.

380

228

View full text Add to dashboard Cite

“…Recently, congenital ZIKV infection without microcephaly at birth has been reported (10) as has postnatal development of microcephaly in infants presumed to be infected congenitally (11). Consequently, follow-up ultrasound examinations may not detect all Zika infection abnormalities, and other highly specific and sensitive diagnostic methods for Zika infection must be implemented.…”

Section: Discussionmentioning

confidence: 99%

Sensitivity and Kinetics of an NS1-Based Zika Virus Enzyme-Linked Immunosorbent Assay in Zika Virus-Infected Travelers from Israel, the Czech Republic, Italy, Belgium, Germany, and Chile

et al. 2017

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Serological diagnosis of Zika virus is challenging due to high crossreactivity of Zika virus with other flavivirus antibodies. Recently, a Zika NS1-based enzyme-linked immunosorbent assay (ELISA) was developed and shown to be highly specific for Zika antibody detection; however, sensitivity was evaluated for only a small number of confirmed Zika-infected patients. In this study, we measured the sensitivity and kinetics of Zika IgM and IgG antibodies using the Zika NS1-based ELISA in 105 samples from 63 returning travelers infected with Zika virus (proven by PCR or neutralization assay) from Israel, Czech Republic, Italy, Belgium, Germany, and Chile. Zika virus IgM was detected from 2 to 42 days post-symptom onset (PSO) with an overall sensitivity of 79% in the first month and 68% until 2 months PSO, while IgG antibodies were detected from 5 days to 3 years PSO with 79% sensitivity. Interestingly, significant differences in IgM sensitivity and IgM detection period were observed between Israeli and European/Chilean Zika-infected travelers, adding to the complexity of Zika infection diagnosis and suggesting that other diagnostic methods should be complemented to reduce false-negative results.

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“…Abnormal brain development, microcephaly (85%), brain calcification between the cortical and subcortical areas, ventriculomegaly, cerebellar hypoplasia, cortical (mostly the frontal lobe)/ subcortical atrophy, craniofacial disproportion (95.8%), corpus callosum hypoplasia, delayed myelination, and enlarged cisterna magna have been reported as brain development defects [51,59]. These findings were symmetric in 75% of the patients [59].…”

Section: Radiologic Image Findings Of Congenital Zika Syndromementioning

confidence: 74%

“…The most frequent clinical symptoms in infants with ZIKV infection are irritability, convulsion, clonus, crying, pyramidal and extrapyramidal symptoms, epilepsy, dysphagia, and persistent primitive reflex [51]. Positive examination findings were reported to be poor head growth and negative z-score, biparietal depression, prominent occiput, excess nuchal skin, congenital clubfoot, arthrogryposis, cleft lip, or cleft palate [51].…”

Section: Congenital and Intrauterine Zika Virus Infectionmentioning

confidence: 99%

“…Positive examination findings were reported to be poor head growth and negative z-score, biparietal depression, prominent occiput, excess nuchal skin, congenital clubfoot, arthrogryposis, cleft lip, or cleft palate [51]. Microcephaly may be present or develop within 5 months after birth in infants with congenital ZIKV infection [52].…”

Section: Congenital and Intrauterine Zika Virus Infectionmentioning

confidence: 99%

See 1 more Smart Citation

Global Alert: Zika Virus-an Emerging Arbovirus

Özkurt¹,

Tanrıverdi²

2017

Eurasian J Med

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Zika virus (ZIKV) is an arbovirus of the Flavivirus genus, and it has an envelope and a single RNA molecule. In early 2016, the World Health Organization declared ZIKV infection to be an emerging global health threat. The major transmission route of the virus to humans is Aedes mosquitoes. ZIKV can be transmitted between humans by transplacental, perinatal, and sexual routes and via blood and body fluids. ZIKV infection usually results in a mild and self-limiting disease with low-grade fever, conjunctivitis, and periorbital edema. Neurological complications such as Guillain-Barré syndrome, meningoencephalitis, acute disseminated encephalomyelitis, acute myelitis, and transverse myelitis have been reported during ZIKV infection. Intrauterine and congenital ZIKV infections have strong teratogenic effects on the fetus. Intrauterine or congenital ZIKV infection can lead to microcephaly, ocular anomalies (such as macular atrophy, pigment mottling, and optic nerve anomalies), and cardiac anomalies (such as atrial or ventricular septal defect). Calcification in the brain between the cortical and subcortical areas, ventriculomegaly, cerebellar hypoplasia, corpus callosum hypoplasia, cortical/subcortical atrophy, delayed myelination, enlarged cisterna magna, and craniofacial disproportion have been reported as brain development defects. ZIKV infection usually results in a mild disease, and it does not require specific therapy. However, complications of infection during the early period of life are serious. Thus, many drugs have been investigated, and vaccine development studies have been conducted to prevent ZIKV infection. Vector control and personal protection from mosquito-borne transmission are important for decreasing the prevalence of ZIKV infection. In particular, pregnant residents or travelers to endemic areas should be carefully protected against mosquito-borne transmission.Keywords: Zika virus, Flavivirus, microcephaly, Guillain-Barré Syndrome, aedes, arbovirus ÖZ Zika virus (ZIKV), Flavivirus ailesinden sivrisineklerle bulaşan zarflı ve tek sarmallı RNA'ya sahip bir arbovirusdur. 2016 yılı başında Dünya Sağlık Örgütü (DSÖ) ZIKV enfeksiyonunun giderek önemi artan bir küresel tehdit olduğunu açıklamıştır. Virusun insanlara esas geçiş yolu Aedes tipi sivrisineklerin ısırmasıdır. İnsanlar arasında transplasental, perinatal, cinsel yolla, ayrıca kan ve vücut sıvıları aracılığı ile bulaşır. ZIKV enfeksiyonu genellikle hafif ve kendini sınırlandıran hastalık olup, düşük derecede ateş, konjuktivit ve periorbital ödem ile seyreder. ZIKV enfeksiyonu esnasında Guillain-Barre sendromu, meningoensefalit, akut dissemine ensefalomyelit (ADEM), akut myelit, transvers myelit gibi nörolojik komplikasyonlar rapor edilmiştir. Intrauterin ve konjenital ZIKV enfeksiyonu fetus üzerinde ağır teratojenik etkiye sahiptir. İntrauterin enfeksiyon mikrosefali, oküler anomaliler (maküler atrofi, pigment beneklenmesi ve optik sinir anomalileri gibi) ve kardiyak anomalilere (atrial veya ventriküler septal defekt gibi) yol açabilir. ...

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Early Growth and Neurologic Outcomes of Infants with Probable Congenital Zika Virus Syndrome

Cited by 182 publications

References 11 publications

Description of 13 Infants Born During October 2015–January 2016 With Congenital Zika Virus Infection Without Microcephaly at Birth — Brazil

Description of 13 Infants Born During October 2015–January 2016 With Congenital Zika Virus Infection Without Microcephaly at Birth — Brazil

Sensitivity and Kinetics of an NS1-Based Zika Virus Enzyme-Linked Immunosorbent Assay in Zika Virus-Infected Travelers from Israel, the Czech Republic, Italy, Belgium, Germany, and Chile

Global Alert: Zika Virus-an Emerging Arbovirus

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