Early gray matter atrophy and neurological deficits in patients with carbon monoxide poisoning

Lei, Junqiang; Wang, Tianhong; Wang, Shuaiwen; Gao, Yue; Wang, Shaoyu; Guo, Shunlin

doi:10.1007/s00234-022-03041-5

Cited by 4 publications

(4 citation statements)

References 42 publications

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“…Likewise, the uptake ratio of the putamen has been associated with visual memory (Chang et al, 2016 ). Thalamic and hippocampal atrophy has been correlated with lower MMSE scores in CO poisoning patients with mixed symptoms (Zhang et al, 2023 ). The thalamus, acting as a hub region for brain functional integration and coordination, has been suggested to be associated with cognitive decline in patients with WMH (Zhu et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, we found no significant atrophy in the deep GM nuclei when comparing patient groups, indicating a lesser role of these structures in the severity of cognitive impairment. DNS patients commonly experience a combination of symptoms like anxiety, depression, fatigue, motor disorders, and mutism (Liu et al, 2020 ; Zhang et al, 2023 ). Structural and functional abnormalities in the thalamus, caudate nucleus, and putamen have been linked to emotional and motor decline in CO poisoning patients (Chen et al, 2013 ; Sun et al, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

“…Our previous study identified greater GM atrophy in the limbic lobes, motor and visual cortices, and DMN in patients with CO poisoning and T2 hyperintense lesions compared to those without these lesions (Zhang et al, 2023). Building upon these findings, we aimed to investigate and compare GM structural alterations in patients with DNS based on different burdens of WM lesions.…”

Section: The Relationship Among Gm Atrophy Wm Lesions Burden and Cogn...mentioning

confidence: 94%

“…GM in the brain plays a crucial role in cognitive processes by facilitating information extraction, exchange, and integration. In a previous study utilizing voxel‐based morphometry (VBM) analysis, we observed a reduction in volume in the medial orbital superior frontal gyrus (SFG) and anterior cingulate cortex (ACC), which correlated with lower Mini‐Mental State Examination (MMSE) scores in patients with CO poisoning (Zhang et al, 2023 ). Another VBM study reported reduced gray matter (GM) volume in the bilateral basal ganglia, left postcentral gyrus, and left hippocampus, which was associated with decreased cognition in CO poisoning patients (Chen et al, 2013 ).…”

Section: Introductionmentioning

confidence: 97%

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Gray matter atrophy and white matter lesions burden in delayed cognitive decline following carbon monoxide poisoning

Zhang,

Wang,

Wang

et al. 2024

Human Brain Mapping

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Gray matter (GM) atrophy and white matter (WM) lesions may contribute to cognitive decline in patients with delayed neurological sequelae (DNS) after carbon monoxide (CO) poisoning. However, there is currently a lack of evidence supporting this relationship. This study aimed to investigate the volume of GM, cortical thickness, and burden of WM lesions in 33 DNS patients with dementia, 24 DNS patients with mild cognitive impairment, and 51 healthy controls. Various methods, including voxel‐based, deformation‐based, surface‐based, and atlas‐based analyses, were used to examine GM structures. Furthermore, we explored the connection between GM volume changes, WM lesions burden, and cognitive decline. Compared to the healthy controls, both patient groups exhibited widespread GM atrophy in the cerebral cortices (for volume and cortical thickness), subcortical nuclei (for volume), and cerebellum (for volume) (p < .05 corrected for false discovery rate [FDR]). The total volume of GM atrophy in 31 subregions, which included the default mode network (DMN), visual network (VN), and cerebellar network (CN) (p < .05, FDR‐corrected), independently contributed to the severity of cognitive impairment (p < .05). Additionally, WM lesions impacted cognitive decline through both direct and indirect effects, with the latter mediated by volume reduction in 16 subregions of cognitive networks (p < .05). These preliminary findings suggested that both GM atrophy and WM lesions were involved in cognitive decline in DNS patients following CO poisoning. Moreover, the reduction in the volume of DMN, VN, and posterior CN nodes mediated the WM lesions‐induced cognitive decline.

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Section: Discussionmentioning

confidence: 99%