Early Glaucoma Detection Using the Humphrey Matrix Perimeter, GDx VCC, Stratus OCT, and Retinal Nerve Fiber Layer Photography

Hong, Samin; Ahn, Hyungwoong; Ha, Sol; Yeom, Ho Yeop; Seong, Gong Je; Hong, Young Jae

doi:10.1016/j.ophtha.2006.09.021

Cited by 55 publications

(47 citation statements)

References 13 publications

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“…[1][2][3][4][5][6] In various studies, [7][8][9][10][11][12] the sensitivity and specificity of the Stratus OCT in detecting early glaucoma has been found to be only moderate to high. OCT instruments employing the Fourier-domain technology have significantly higher resolution and scan speed, improved image segmentation and better measurement reproducibility compared with the timeFdomain OCT. [1][2][3][4][5][6] Though the technology is new, information on the diagnostic accuracy of the different Fourier-domain OCT instruments to detect glaucoma of different severity, is increasing.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of nerve fibre layer, macular thickness and optic disc measurements made with the RTVue-100 optical coherence tomograph to detect glaucoma

Garas

Vargha

Holló

2010

Eye

138

107

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Purpose To evaluate the diagnostic accuracy of retinal nerve fibre layer thickness (RNFLT), ganglion cell complex (GCC), and optic disc measurements made with the RTVue-100 Fourier-domain optical coherence tomography (OCT) to detect glaucoma in a Caucasian referral population. Methods One randomly selected eye of 286 Caucasian patients (93 healthy, 36 ocular hypertensive, 46 preperimetric glaucoma, and 111 perimetric glaucoma eyes) was evaluated. Results Using the software-provided classification, for the total population sensitivity did not exceed 73.6% for the optic nerve head parameters, and 62.7% for the other parameters. Specificity was high (94.6-100%) for most RNFLT and GCC parameters, but low (72.0-76.3%) for the optic disc parameters. Positive predictive value varied between 98.1 and 100% for the main RNFLT parameters, 92.6 and 100% for the 16 RNFLT sectors, 92.4 and 99.0% for the GCC parameters, but did not exceed 86.3% for any of the optic disc parameters. Positive likelihood ratio (PLR) was higher than 10 for average, inferior and superior RNFLT (25.5 to infinite), 12 of the 16 RNFLT sectors (12.6 to infinite), and three of the four GCC parameters (40.0 to 48.6). No optic disc parameter had a PLR higher than 3.0. Conclusions RNFLT and GCC parameters of the RTVue-100 Fourier-domain OCT showed moderate sensitive but high specificity, positive predictive value and PLR for detection of glaucoma. The optic disc parameters had lower diagnostic accuracy than the RNFLT and GCC parameters.

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Section: Introductionmentioning

confidence: 99%

Diagnostic accuracy of nerve fibre layer, macular thickness and optic disc measurements made with the RTVue-100 optical coherence tomograph to detect glaucoma

Garas

Vargha

Holló

2010

Eye

138

107

View full text Add to dashboard Cite

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“…Measurements of the functional integrity of the visual system should deliver further information. To increase diagnostic value, the validity of morphological measurements and sensory testing has been compared [1][2][3][4][5] and relationship between procedures has been studied. 6 It has been found that the combinations of structural and functional test might be helpful for the identification of glaucomatous damage.…”

Section: Introductionmentioning

confidence: 99%

“…6 It has been found that the combinations of structural and functional test might be helpful for the identification of glaucomatous damage. 1,[7][8][9] In recent years, new sensory tests, as well as morphological techniques, have been developed to detect glaucomatous defects at an early stage. It has been shown, that quantitative measurements of the retinal nerve fibre layer 10 and perimetry using frequency-doubling technique (FDT) 11,12 may be helpful in glaucoma diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Frequency doubling technique perimetry and spectral domain optical coherence tomography in patients with early glaucoma

Horn

Mardin

Bendschneider

et al. 2010

Eye

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“…2 Currently, standard automated perimetry (SAP) is the clinical test most often used for evaluating the visual field (VF) in these patients, however, many newer instruments are continuously being developed to improve the diagnostic yield and shorten the test duration, to help reduce the fatigue induced by the test and increase patient acceptability. [3][4][5][6][7] Frequency doubling technology (FDT) is based on a phenomenon called the 'frequency doubling illusion', which occurs when low spatial frequency (o1 cycle/degree) grating undergoes high temporal frequency (415 Hz) counterphase flicker. 3,4 This type of illusion is thought to be mediated by the magnocellular retinal ganglion cells, whose loss, probably because of reduced redundancy, may be detectable in early glaucoma.…”

Section: Introductionmentioning

confidence: 99%

Learning effect in visual field testing of healthy subjects using Humphrey Matrix frequency doubling technology perimetry

Pierre-Filho¹,

Gomes²,

Pierre³

et al. 2009

Eye

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Purpose To evaluate the learning effect of frequency doubling technology (FDT) perimetry using the Humphrey Matrix perimeter in healthy subjects with no perimetric experience. Methods One eye of 28 healthy adults who had no history of visual field testing underwent three Matrix tests using 24-2 programme with full-threshold strategy. The results of the first session were compared with those of the second, and the third sessions. Learning effect was defined as an improvement at results for duration, perimetric indices, and the number of points with a Po5 and o1% in the total and pattern deviation maps. Anderson's criteria were applied to define abnormal examinations. Results The mean in the mean deviation global index was À7.40 ± 1.49 dB in the first session, À4.64±0.97 dB in the second session, and À3.29±0.93 dB in the third session. Pattern standard deviations were decreased as the tests were repeated (Po0.01). Test duration, fixation losses, false negative, and the number of points with a Po5 and o1% in the total and pattern deviation maps rate were also changed significantly (Po0.05). Among the criteria suggested by Anderson, the Glaucoma Hemifield Test performed better in all session tests. The false-positive rates ranged from 50% (95% confidence intervals [CI] 30.6-69.4%) to 64% (95% CI 44.1-81.4%) for the first session, 29% (95% CI 13.2-48.7%) to 54% (95% CI 33.9-72.5%) for the second session, and from 18% (95% CI 6.1-36.9%) to 32% (95% CI 15.9-52.4%) for the third session. ConclusionsThe results of this study show that the learning effect for Humphrey Matrix FDT perimetry must be considered in normal individuals with no perimetric experience.

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Early Glaucoma Detection Using the Humphrey Matrix Perimeter, GDx VCC, Stratus OCT, and Retinal Nerve Fiber Layer Photography

Cited by 55 publications

References 13 publications

Diagnostic accuracy of nerve fibre layer, macular thickness and optic disc measurements made with the RTVue-100 optical coherence tomograph to detect glaucoma

Diagnostic accuracy of nerve fibre layer, macular thickness and optic disc measurements made with the RTVue-100 optical coherence tomograph to detect glaucoma

Frequency doubling technique perimetry and spectral domain optical coherence tomography in patients with early glaucoma

Learning effect in visual field testing of healthy subjects using Humphrey Matrix frequency doubling technology perimetry

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