Early general movements are associated with developmental outcomes at 4.5–5 years

Olsen, Joy E.; Cheong, Jeanie L.Y.; Eeles, Abbey L; FitzGerald, Tara L; Cameron, Kate L; Albesher, Reem A.; Anderson, Peter J.; Doyle, Lex W.; Spittle, Alicia J

doi:10.1016/j.earlhumdev.2020.105115

Cited by 13 publications

(11 citation statements)

References 30 publications

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“…Several assessments of HRQoL following preterm birth have applied multi-dimensional health profile measures that disaggregate outcomes across dimensions or subscales [11][12][13]. A small number of recent assessments of the HRQoL of pretermborn children [14][15][16] have applied the Pediatric Quality of life Inventory ™ (PedsQL ™ ) [17], which was designed to provide an age-specific modular approach to measuring HRQoL in healthy children and adolescents, as well as those with acute and chronic health conditions, across the broadest empirically feasible age groups. However, these studies are based on case series or cohorts with relatively small samples, with each limited to application in one country.…”

Section: Introductionmentioning

confidence: 99%

Health-related quality of life of children born very preterm: a multinational European cohort study

Kim

Sentenac²,

Lebeer³

et al. 2022

Qual Life Res

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Purpose This study aims to (1) describe the health-related quality of life (HRQoL) outcomes experienced by children born very preterm (28–31 weeks’ gestation) and extremely preterm (< 28 weeks’ gestation) at five years of age and (2) explore the mediation effects of bronchopulmonary dysplasia (BPD) and severe non-respiratory neonatal morbidity on those outcomes. Methods This investigation was based on data for 3687 children born at < 32 weeks’ gestation that contributed to the EPICE and SHIPS studies conducted in 19 regions across 11 European countries. Descriptive statistics and multi-level ordinary linear squares (OLS) regression were used to explore the association between perinatal and sociodemographic characteristics and PedsQL™ GCS scores. A mediation analysis that applied generalised structural equation modelling explored the association between potential mediators and PedsQL™ GCS scores. Results The multi-level OLS regression (fully adjusted model) revealed that birth at < 26 weeks’ gestation, BPD status and experience of severe non-respiratory morbidity were associated with mean decrements in the total PedsQL™ GCS score of 0.35, 3.71 and 5.87, respectively. The mediation analysis revealed that the indirect effects of BPD and severe non-respiratory morbidity on the total PedsQL™ GCS score translated into decrements of 1.73 and 17.56, respectively, at < 26 weeks’ gestation; 0.99 and 10.95, respectively, at 26–27 weeks’ gestation; and 0.34 and 4.80, respectively, at 28–29 weeks’ gestation (referent: birth at 30–31 weeks’ gestation). Conclusion The findings suggest that HRQoL is particularly impaired by extremely preterm birth and the concomitant complications of preterm birth such as BPD and severe non-respiratory morbidity.

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Section: Introductionmentioning

confidence: 99%

Health-related quality of life of children born very preterm: a multinational European cohort study

Kim

Sentenac²,

Lebeer³

et al. 2022

Qual Life Res

View full text Add to dashboard Cite

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“…Abnormal general movements, assessed between < 32-weeks gestational age and term equivalent age, showed to be associated with worse motor, functional and cognitive outcomes at 4.5-5 years of age. 10 Moreover, synchronized cramped movements, as assessed between one and three months, were predictive of the neurological outcome at two years corrected age, while poor repertoire of movements predictivity was significantly enhanced by heart rate variability evaluated at one month corrected age. 11 The neurobehavioural assessment at term equivalent age performed by the NICU Network Neurobehavioral Scale 12 was found to be predictive of mental and motor outcomes at 18 months corrected age 13 and of motor status at 24 months corrected age.…”

Section: Accepted Manuscriptmentioning

confidence: 87%

Preterm Newborn Adaptive Responses to Daily Nursing during Neonatal Intensive Care Unit Stay, Associate with Neurodevelopment, 2 Years Later

et al. 2023

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Objective: To evaluate if adaptive responses of very preterm newborns to NICU daily nursing, specifically bathing and weighing procedures, are associated with their neurodevelopment two years later. Study design: Twenty-six very preterm newborns, with a gestational age < 32 weeks, were enrolled. Infants' adaptive responses to daily nursing were evaluated, at 30-32-35 postmenstrual age (PMA) weeks, by an observational sheet. Neurodevelopment was assessed, at 24 months of corrected age, by the Bayley Scales of Infant and Toddler Development, third edition. Autonomic, motor, and self-regulatory responses to NICU nursing were analyzed, by Spearman's correlation coefficient and multivariate linear regression, with Bayley’s cognitive, language, and motor scales. Results: Significant (P < 0.05) positive correlations of self-regulatory and autonomic responses to nursing with all Bailey’s scales were found at 30- and 32-weeks PMA. At 35 weeks PMA, only self-regulatory responses had significant positive correlations with all Bailey’s scales. When adjusted for birth weight and sex, the significant associations were confirmed only at 30- and 32-weeks PMA. Conclusion: Very preterm newborn adaptive responses to NICU daily nursing reveal to be positively related to forthcoming neurodevelopment two years later, as early as the 30th week PMA. Helping preterm babies to adapt to daily NICU nursing may promote their future neurobeahaviour.

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“…Abnormal general movements, assessed between <32 weeks of gestational age and term equivalent age, showed to be associated with worse motor, functional, and cognitive outcomes at 4.5 to 5 years of age. 10 Moreover, synchronized cramped movements, as assessed between 1 and 3 months, were predictive of the neurological outcome at 2 years of corrected age, while poor repertoire of movements predictivity was significantly enhanced by heart rate variability evaluated at 1 month of corrected age. 11 The neurobehavioral assessment at term equivalent age performed by the "NICU Network Neurobehavioral Scale" 12 was found to be predictive of mental and motor outcomes at 18 months of corrected age 13 and of motor status at 24 months of corrected age.…”

mentioning

confidence: 85%

Preterm Newborn Adaptive Responses to Daily Nursing during Neonatal Intensive Care Unit Stay, Associate with Neurodevelopment, 2 Years Later

et al. 2021

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Objective This study aimed to evaluate if adaptive responses of very preterm newborns to neonatal intensive care unit (NICU) daily nursing, specifically bathing and weighing procedures are associated with their neurodevelopment after 2 years. Study Design Twenty-six very preterm newborns, with a gestational age <32 weeks, were enrolled. Infants' adaptive responses to daily nursing were evaluated, at 30 to 32 to 35 postmenstrual age (PMA) weeks by an observational sheet. Neurodevelopment was assessed at 24 months of corrected age by the Bayley Scales of Infant and Toddler Development, third edition. Autonomic, motor, and self-regulatory responses to NICU nursing were analyzed by Spearman's correlation coefficient and multivariate linear regression with Bayley's cognitive, language, and motor scales. Results Significant (p < 0.05) positive correlations of self-regulatory and autonomic responses to nursing with all Bayley's scales were found at 30- and 32-week PMA. At 35-week PMA, only self-regulatory responses had significant positive correlations with all Bayley's scales. When adjusted for birth weight and sex, the significant associations were confirmed only at 30- and 32-week PMA. Conclusion Very preterm newborn adaptive responses to NICU daily nursing reveal to be positively related to forthcoming neurodevelopment 2 years later, as early as the 30-week PMA. Helping preterm babies to adapt to daily NICU nursing may promote their future neurobehavior. Key Points

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Early general movements are associated with developmental outcomes at 4.5–5 years

Cited by 13 publications

References 30 publications

Health-related quality of life of children born very preterm: a multinational European cohort study

Health-related quality of life of children born very preterm: a multinational European cohort study

Preterm Newborn Adaptive Responses to Daily Nursing during Neonatal Intensive Care Unit Stay, Associate with Neurodevelopment, 2 Years Later

Preterm Newborn Adaptive Responses to Daily Nursing during Neonatal Intensive Care Unit Stay, Associate with Neurodevelopment, 2 Years Later

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