Early Gallbladder Cancer

Wagholikar, Gajanan D; Behari, Anu; Krishnani, Narendra; Kumar, Ashok; Sikora, Sadiq S.; Saxena, Rajan; Kapoor, Vinay K.

doi:10.1016/s1072-7515(02)01214-0

Cited by 29 publications

(40 citation statements)

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“…Some series support simple cholecystectomy as sufficient management [10], whereas others call for radical resection in these cases [11][12][13]. Data are scant, because these lesions are uncommon.…”

Section: T1b Gbcmentioning

confidence: 99%

Current Management of Gallbladder Carcinoma

et al. 2010

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Section: T1b Gbcmentioning

confidence: 99%

Current Management of Gallbladder Carcinoma

et al. 2010

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“…En los órganos de fácil acceso es posible el seguimiento de estas lesiones, sin embargo, en la vesícula biliar I N V E S T I G A C I Ó N esto no es posible, ya que una vez extraído el órgano el proceso se interrumpe. Escasa información existe respecto de la forma más precoz del CVB y que corresponde al CMu [39][40][41][42][43] . En países con alta incidencia de cáncer vesicular como Chile, India y Japón, el carcinoma mucoso puede llegar a representar hasta 15% del total de cánce-res vesiculares diagnosticados en colecistectomías 36 .…”

Section: Discussionunclassified

Desde la displasia hasta el cáncer de la vesícula biliar

et al. 2009

Rev. méd. Chile

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“…5,[11][12][13][14][15][16][17][18][19][20][21][22][23][24] All the studies were non-randomized control trials. Table 1 and 2 respectively show the character of included literatures and NOS quality assessment scale.…”

Section: Characteristics Of Included Literatures and Quality Assessmentmentioning

confidence: 99%

“…5,[11][12][13][14][16][17][18][19]21,23,24 Data of 1-year survival rate from nine studies can be pooled (Figure 2). Heterogeneity exists (χ2 = 11.54, P = 0.17, I2 = 31%), hence random model was used, and the result shows RR is obviously better than SC in increasing 1-year survival rate (OR=3.28, 95% CI: 1.83-5.89, P<0.0001).…”

Section: Survival Rate Analysismentioning

confidence: 99%

Simple cholecystectomy versus radical resection for stage Ⅱ gallbladder cancer: a meta-analysis

Cheng

Qiu

et al. 2017

Int Surg J

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INTRODUCTIONGBC was first reported more than two hundred years ago, but the poor therapeutic effect for GBC patients is still frustrating now, the 5-year survival rate is no more than 5%, and the mean survival time is only about half a year. 1 It still relies on surgical method to treat and provide the possibilities of favorable prognosis, while auxiliary methods like radiotherapy and chemotherapy are likely to reduce the chance of tumor relapse and improve the longterm survival of GBC patients. 2 GBC patients' survival time -one of the major indicators for prognosis judgment isn't affected by sexuality, age or ABSTRACT Background: GBC was first reported more than two hundred years ago, but the poor therapeutic effect for GBC patients is still frustrating now, the 5-year survival rate is no more than 5%, and the mean survival time is only about half a year. The objective of this study was to evaluate the importance of radical resection in the treatment of Nevin II and T1b stage gallbladder cancer (stage II GBC) by analyzing the survival rate and tumor recurrence rate after accepting simple cholecystectomy (SC) and radical resection (RR). Methods: PubMed, Embase, Chinese National Knowledge Infrastructure and Wanfang databases was searched from inception to February 2016. Quality assessment was conducted in each of the available studies by using the validated Newcastle-Ottawa Quality Assessment Scale (NOS) for cohort and case-control studies. Publication bias was also assessed by using a funnel plot. The odds ratio (OR) and its 95% confidence interval (95% CI) were employed to estimated effect size. All statistical analyses were carried out using Rev Man 5.2 software. Results: A total of fifteen studies encompassing 424 patients meeting the search criteria were included. Pooled analyses revealed that comparing to simple cholecystectomy, radical resection can significantly increase the 1-, 3-and 5-year survival rate of patients with stage II GBC (OR = 3.28, 95% CI: 1.83-5.89, P<0.0001; OR = 2.52, 95% CI: 1. P = 0.0006; OR = 3.19, P<0.0001), and patients after radical resection have a significant lower tumor recurrence rate (OR = 0.30, 95% CI: 0.11-0.80, P = 0.02). Conclusions:The short-and long-term survival rate of patients with stage II GBC following radical resection is obviously higher than that of patients receiving simple cholecystectomy, and the tumor recurrence rate is obviously lower. Radical resection would be a better choice for stage II GBC.

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Early Gallbladder Cancer

Cited by 29 publications

References 0 publications

Current Management of Gallbladder Carcinoma

Current Management of Gallbladder Carcinoma

Desde la displasia hasta el cáncer de la vesícula biliar

Simple cholecystectomy versus radical resection for stage Ⅱ gallbladder cancer: a meta-analysis

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