Early food allergy and respiratory allergy symptoms and attention‐deficit/hyperactivity disorder in Chinese children: A cross‐sectional study

Jiang, Xiaodong; Shen, Chun; Dai, Yuan; Fan, Jian‐Gao; Li, Shenghui; Shen, Xiaoming; Hu, Yan; Li, Fēi

doi:10.1111/pai.12888

Cited by 20 publications

(19 citation statements)

References 26 publications

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“…Food intake may affect the behavior of children with ADHD through a mechanism that involves a non-IgE-mediated, cell-mediated or non-allergic response (167). A cross-sectional study from China suggested that early food allergies in school-age children are associated with ADHD (168). Children with ADHD reacted severely to allergenic foods including cow's milk, wheat and eggs (167,169).…”

Section: Inflammation/mcs and Adhdmentioning

confidence: 99%

Mast cell‑mediated neuroinflammation may have a role in attention deficit hyperactivity disorder (Review)

Song

Huang

et al. 2020

Exp Ther Med

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Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental and behavioral disorder with a serious negative impact on the quality of life from childhood until adulthood, which may cause academic failure, family disharmony and even social unrest. The pathogenesis of ADHD has remained to be fully elucidated, leading to difficulties in the treatment of this disease. Genetic and environmental factors contribute to the risk of ADHD development. Certain studies indicated that ADHD has high comorbidity with allergic and autoimmune diseases, with various patients with ADHD having a high inflammatory status. Increasing evidence indicated that mast cells (MCs) are involved in the pathogenesis of brain inflammation and neuropsychiatric disorders. MCs may cause or aggravate neuroinflammation via the selective release of inflammatory factors, interaction with glial cells and neurons, activation of the hypothalamic-pituitary adrenal axis or disruption of the blood-brain barrier integrity. In the present review, the notion that MC activation may be involved in the occurrence and development of ADHD through a number of ways is discussed based on previously published studies. The association between MCs and ADHD appears to lack sufficient evidence at present and this hypothesis is considered to be worthy of further study, providing a novel perspective for the treatment of ADHD.

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Section: Inflammation/mcs and Adhdmentioning

confidence: 99%

Mast cell‑mediated neuroinflammation may have a role in attention deficit hyperactivity disorder (Review)

Song

Huang

et al. 2020

Exp Ther Med

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“…19 Moreover, allergic reactions have been proposed to foster an imbalance in cholinergic/adrenergic activity within the central nervous system, leading to ADHD behaviours in some children, and were reported to independently and synergistically contribute to a higher risk of ADHD in children. 20 These potential confounders were all adjusted for in the present study.…”

Section: Discussionmentioning

confidence: 99%

Incidence and risk of attention‐deficit hyperactivity disorder in children with amblyopia: A nationwide cohort study

Tsai

et al. 2019

Clinical Exper Ophthalmology

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Importance The association between visual deficits and attention disorders has been reported but remains unproven. Background The objective of this study was to evaluate the risk of attention‐deficit hyperactivity disorder (ADHD) in children with amblyopia. Design Population‐based, cohort study. Participants The dataset from the Taiwan National Health Insurance Research Database in 2000 to 2010. Methods A total of 6817 patients aged <18 years with newly diagnosed amblyopia were identified. Four age‐ and sex‐matched controls without amblyopia were included for each patient, that is, 27268 controls. Main Outcome Measures The primary outcome was the risk of ADHD. The secondary outcomes were age at ADHD onset and use of ADHD medication. Results During a mean observation period of 7.18 years, the incidence of ADHD per 1000 person‐years was 7.02 in the amblyopia group and 4.61 in the control group (P < 0.0001). The ADHD risk in the amblyopia group was 1.81 times that in the control group (hazard ratio 1.81; 95% confidence interval 1.59‐2.06). After stratification by amblyopia subtype, the greatest risk was in the deprivation type (hazard ratio 2.14; 95% confidence interval 1.56‐2.92) followed by the strabismic (hazard ratio 2.09; 95% confidence interval 1.15‐3.79) and refractive (hazard ratio 1.76; 95% confidence interval 1.54‐2.02) types. Age at ADHD onset was younger in the amblyopia group (median 8.14 vs 8.45 years; P = 0.0096). The average duration of neuropsychiatric medication use was comparable between groups (P = 0.98). Conclusions and Relevance The ADHD risk is higher in children with amblyopia.

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“…In addition, there is consistent evidence from populationbased studies of a significant association between asthma and attention deficit hyperactivity disorder (ADHD) both in children and adults 46,47 . Interestingly, also the allergic multimorbidity has been associated with higher ADHD 48 . Depression and anxiety, the most common mental health disorders, have also been associated with allergic diseases or their multimorbidity both in children and adults at the population level 43,49,50 .…”

Section: Beyond Medallmentioning

confidence: 99%

Mechanisms of the Development of Allergy (MeDALL) Study: A Systems Medicine Approach to Understand Allergic Diseases

Antó¹,

Bousquet²

2021

BRN

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Early food allergy and respiratory allergy symptoms and attention‐deficit/hyperactivity disorder in Chinese children: A cross‐sectional study

Cited by 20 publications

References 26 publications

Mast cell‑mediated neuroinflammation may have a role in attention deficit hyperactivity disorder (Review)

Mast cell‑mediated neuroinflammation may have a role in attention deficit hyperactivity disorder (Review)

Incidence and risk of attention‐deficit hyperactivity disorder in children with amblyopia: A nationwide cohort study

Mechanisms of the Development of Allergy (MeDALL) Study: A Systems Medicine Approach to Understand Allergic Diseases

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