Early Fever Is Associated With Clinical Outcomes in Patients With Coronavirus Disease

Abstract

Fever is one of the typical symptoms of coronavirus disease (COVID-19). We aimed to investigate the association between early fever (EF) and clinical outcomes in COVID-19 patients. A total of 1,014 COVID-19 patients at the Leishenshan Hospital were enrolled and classified into the EF and non-EF groups based on whether they had fever within 5 days of symptom onset. Risk factors for clinical outcomes in patients with different levels of disease severity were analyzed using multivariable analyses. Time from symptom onset to symptom alleviation, CT image improvement, and discharge were longer for patients with moderate and severe disease in the EF group than in the non-EF group. Multivariable analysis showed that sex, EF, eosinophil number, C-reactive protein, and IL-6 levels were positively correlated with the time from symptom onset to hospital discharge in moderate cases. The EF patients showed no significant differences in the development of acute respiratory distress syndrome, compared with the non-EF patients. The Kaplan–Meier curve showed no obvious differences in survival between the EF and non-EF patients. However, EF patients with increased temperature showed markedly lower survival than the non-EF patients with increased temperature. EF had no significant impact on the survival of critically ill patients, while an increase in temperature was identified as an independent risk factor. EF appears to be a predictor of longer recovery time in moderate/severe COVID-19 infections. However, its value in predicting mortality needs to be considered for critically ill patients with EF showing increasing temperature.

Improved outcomes in patients with chronic lymphocytic leukaemia infected during the omicron BA.5 subvariant surge

“…Among the latter, the independent risk factors for hospitalization were diabetes, fever and active CLL therapy. Similar to our findings, diabetes, fever and active treatment for CLL have previously been reported as risk factors for severe COVID‐19 and mortality 4‐6 . Especially it is of clinical importance that treatment with venetoclax plus anti‐CD20 antibodies is shown to be a risk factor for hospitalization, a finding that is probably explained mainly by the known association between anti‐CD20‐based therapies and the development of severe COVID‐19 7 .…”

“…Similar to our findings, diabetes, fever and active treatment for CLL have previously been reported as risk factors for severe COVID-19 and mortality. [4][5][6] Especially it is of clinical importance that treatment with venetoclax plus anti-CD20 antibodies is shown to be a risk factor for hospitalization, a finding that is probably explained mainly by the known association between anti-CD20-based therapies and the development of severe COVID-19. 7 Interestingly, 32.4% (11/34) of the hospitalized patients actually had mild to moderate COVID-19.…”

Mathematical Simulation Analysis of Body Temperature Observations Covid-19 Patients

“…Fever is the body's defense mechanism in fighting microorganism infections and heat generation is a response to the body's immune warfare. Fever is the diagnostic basis for infection in the Corona-19 virus (Ding et al, 2021). The results of the study data showed that the body temperature of patients who were diagnosed positive for Covid-19 with swab results from the laboratory experienced a hot fever at a minimum body temperature of 37.60 o C. Based on research conducted (Ding et al, 2021), that humans who experienced influenza strain infection had a fever with a body temperature of 38-41•C.…”

“…Fever is the diagnostic basis for infection in the Corona-19 virus (Ding et al, 2021). The results of the study data showed that the body temperature of patients who were diagnosed positive for Covid-19 with swab results from the laboratory experienced a hot fever at a minimum body temperature of 37.60 o C. Based on research conducted (Ding et al, 2021), that humans who experienced influenza strain infection had a fever with a body temperature of 38-41•C. The results of the patient data in the study had a fever with a body temperature between 37.6 o C -38.90 o C, and swab results.…”

Short‐term exposure to ambient air pollution and COVID‐19 severity during SARS‐CoV‐2 Delta and Omicron waves: A multicenter study

“…This significant relationship was seen during both waves considered in the present study. Although various analyses show that increased body temperature does not necessarily predict a worse outcome of SARS‐CoV‐2 infection, 80 early fever was associated with remarkably lower survival in COVID‐19 90 . Moreover, fatigue was demonstrated to be linearly related to infection severity 80 .…”