Early fetal megacystis between 11 and 15 weeks of gestation

Abstract

We found a high rate of associated malformations, especially intestinal malformations. The systematic evaluation of the intestinal enzymes in the amniotic fluid and urine samples might be an important aid in the diagnosis of multiple malformations, such as cloacal dysgenesis.

Vesicocentesis at 10–14 weeks of gestation for treatment of fetal megacystis

“…recent study of 16 cases with fetal megacystis between 11 and 15 weeks' gestation, 13 patients opted for termination of pregnancy 3 ; in four of these the fetal karyotype was abnormal. In Case 4 in our study, the patient decided on termination of pregnancy following reappearance of megacystis after a single aspiration.…”

“…Two studies reporting on 21 cases of fetal megacystis found that the incidence of chromosomal abnormality was 20-25% with the most common being trisomies 21, 18 and 13 2,3 . Other anomalies such as the VACTERL syndrome and cystic hygroma have also been associated with the condition 3,4 . Depending on the fluid volume, fetal karyotype may be determined either from the bladder aspirate or from simultaneous amniocentesis.…”

“…One such defect is fetal megacystis, which, although it only occurs in 0.06-0.3% of cases at this gestation, presents a management dilemma 2,3 . Without intervention the condition may resolve spontaneously 4 or may progress to severe obstructive uropathy 5 which later in pregnancy may or may not be suitable for, or even improved by, bladder drainage.…”

Ultrasonographic Evaluation of Foetal Hydronephrosis

“…It occurs mainly because of abnormal distribution of collagenous and muscular fibers in this region. It is more common in males, being bilateral in 21 to 36% of the cases [17] . In our study we also found that the condition was more commonly associated with male babies.…”

Isolated congenital megacystis with spontaneous resolution: a case report

“…Congenital megacystis is an infrequently occurring anomaly investigated during prenatal ultrasound screening, with a prevalence of about 0.06 to 0.25% 1) . The outcome of this condition is different according to the gestational age at diagnosis 2) .…”