EARLY EXPRESSION OF bcl-2 PROTEIN IN THE ADENOMA-CARCINOMA SEQUENCE OF COLORECTAL NEOPLASIA

NF‐κB and apoptosis in colorectal tumourigenesis

“…We show here that in accordance with increased apoptosis, Bcl‐2 immunoreactivity decreased in colorectal tumour progression. This is also consistent with previous reports [19,36–38]. In contrast, we were not able to establish a relationship between the expression of phosphorylated p53 and apoptosis.…”

Evidence that the p53 negative / Bcl-2 positive phenotype is an independent indicator of good prognosis in colorectal cancer: A tissue microarray study of 460 patients

“…In the normal gastrointestinal tract Bcl-2 expression has been detected in the basal cells of crypts. Bcl-2 expression has also been described in the majority (up to 85%) of colorectal adenomas, with reduced expression on progression to invasive carcinoma [25,26]. Despite the defined role of Bcl-2 protein in suppression of apoptosis, in colorectal cancer the evidence suggests that Bcl-2 expression is correlated with favourable parameters [27] and a better prognosis [28].…”

Expression of apoptotic and proliferation markers in meningiomas

“…A similar association has been recently observed in colorectal carcinomas. 23 A possible mechanism of interaction would involve bcl-2 inhibiting apoptosis mediated by wild-type p53, which appears to produce a benign neoplasm.…”