Early experience of an infectious and tropical diseases unit during the coronavirus disease (COVID-19) pandemic, Florence, Italy, February to March 2020

Lagi, Filippo; Piccica, Matteo; Graziani, Lucia; Vellere, Iacopo; Botta, Annarita; Tilli, Marta; Ottino, Letizia; Borchi, Beatrice; Pozzi, Marco; Bartalesi, Filippo; Mencarini, Jessica; Spinicci, Michele; Zammarchi, Lorenzo; Pieralli, Filippo; Zagli, Giovanni; Nozzoli, Carlo; Romagnoli, Stefano; Bartoloni, Alessandro

doi:10.2807/1560-7917.es.2020.25.17.2000556

Cited by 59 publications

(47 citation statements)

References 8 publications

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“…Four studies were excluded due to unavailability of the full-text. Finally, 56 papers ( [21] , [22] , [23] , [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] , [72] , [73] , [74] , [75] , [76] ) entered into meta-analysis for primary outcomes (mortality and ICU admission) and 198 papers [ 16 , 18 , [21] , [22] , [23] , [24] , [25] , [26] ,…”

Section: Resultsmentioning

confidence: 99%

Cardiovascular diseases burden in COVID-19: Systematic review and meta-analysis

Hessami

Shamshirian

Heydari

et al. 2021

The American Journal of Emergency Medicine

120

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Background High rate of cardiovascular disease (CVD) have been reported among patients with novel coronavirus disease (COVID-19). Meanwhile there were controversies among different studies about CVD burden in COVID-19 patients. Hence, we aimed to study CVD burden among COVID-19 patients, using a systematic review and meta-analysis. Methods We have systematically searched databases including PubMed, Embase, Cochrane Library, Scopus, Web of Science as well as medRxiv pre-print database. Hand searched was also conducted in journal websites and Google Scholar. Meta-analyses were carried out for Odds Ratio (OR) of mortality and Intensive Care Unit (ICU) admission for different CVDs. We have also performed a descriptive meta-analysis on different CVDs. Results Fifty-six studies entered into meta-analysis for ICU admission and mortality outcome and 198 papers for descriptive outcomes, including 159,698 COVID-19 patients. Results of meta-analysis indicated that acute cardiac injury, (OR: 13.29, 95% CI 7.35-24.03), hypertension (OR: 2.60, 95% CI 2.11-3.19), heart Failure (OR: 6.72, 95% CI 3.34-13.52), arrhythmia (OR: 2.75, 95% CI 1.43-5.25), coronary artery disease (OR: 3.78, 95% CI 2.42-5.90), and cardiovascular disease (OR: 2.61, 95% CI 1.89-3.62) were significantly associated with mortality. Arrhythmia (OR: 7.03, 95% CI 2.79-17.69), acute cardiac injury (OR: 15.58, 95% CI 5.15-47.12), coronary heart disease (OR: 2.61, 95% CI 1.09-6.26), cardiovascular disease (OR: 3.11, 95% CI 1.59-6.09), and hypertension (OR: 1.95, 95% CI 1.41-2.68) were also significantly associated with ICU admission in COVID-19 patients. Conclusion Findings of this study revealed a high burden of CVDs among COVID-19 patients, which was significantly associated with mortality and ICU admission. Proper management of CVD patients with COVID-19 and monitoring COVID-19 patients for acute cardiac conditions is highly recommended to prevent mortality and critical situations.

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Section: Resultsmentioning

confidence: 99%

Cardiovascular diseases burden in COVID-19: Systematic review and meta-analysis

Hessami

Shamshirian

Heydari

et al. 2021

The American Journal of Emergency Medicine

120

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“…For cohorts in China reporting on hospitalised patients, the prevalence of COPD has ranged from 0 to 10% ( table 1 ) [ 10 – 41 ]. As data from other nations have trickled in, the figures for COPD amongst hospitalised COVID-19 patients appear to be similar, with estimates in New York City ranging from 2.4 to 14% [ 42 – 45 ] and in Italy ranging from 5.6 to 9.2% [ 46 – 48 ]. Data from ICU-only cohorts, however, have been more variable.…”

Section: Is Copd a Risk Factor For Covid-19?mentioning

confidence: 96%

COVID-19 and COPD

et al. 2020

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“…As a confirm of this National panorama, in a large cohort of more than 1500 patients of the Lombardy Region admitted to ICUs, men represented more than 80% of the patients just after 40 years of age [ 12 ]. In Florence, the COCORA multidisciplinary group found that hospitalized patients were prevalently males (65.5% vs 34.5%, p 0.045) and a strikingly majority were ICU-transferred (87.5% vs 12.5%) [ 13 ]. Thus, within Italy, severe clinical course and deaths from COVID-19 are mainly observed among older, male patients confirming lower rates of severe disease among women and younger individuals overlapping data initially described in China [ 14 ].…”

Section: Main Textmentioning

confidence: 99%

A gendered magnifying glass on COVID-19

2020

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COVID-19 pandemia is affecting Countries worldwide with a gendered death excess as being a male represents, especially in the 50–69 years age group, an unfavourable factor. Females are constitutionally prone to defend themselves against pathogens with a stronger efficiency than males. As a fact, several genes involved into the regulation of the innate and adaptive immune response are strategically placed on the X-chromosome and, among them, pathogen-related receptors (PRRs), such as Toll-like receptor 7, suitable to recognize ssRNAs and trigger a gendered successful anti-viral fight. On the other hand, a more regulated IL-6 production and a more contained inflammation after the encounter of a pathogen supply score points in favour of the female sex in the view that an abnormal and exaggerated cytokine release does represent the hallmark of the deathful SARS-CoV-2 infection. The sex-prevalent expression of the attachment and permissive molecules ACE2 and TMPRSS2 further supports the concept of a male-oriented vulnerability. In this review, the possible role of biological and immunological sex differences into the higher morbidity and mortality of SARS-CoV-2 between females and males are discussed.

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Early experience of an infectious and tropical diseases unit during the coronavirus disease (COVID-19) pandemic, Florence, Italy, February to March 2020

Cited by 59 publications

References 8 publications

Cardiovascular diseases burden in COVID-19: Systematic review and meta-analysis

Cardiovascular diseases burden in COVID-19: Systematic review and meta-analysis

COVID-19 and COPD

A gendered magnifying glass on COVID-19

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