Early evidence of the artificial transfer/transplant of mitochondria to oocytes and zygotes by MitoCeption

Cabrera, Francisco; Castañeda, Verónica; Morales, Emilia; Velarde, Francesca; Ortega, Mayra; León-Sosa, Ariana; Jørgensen, Christian; Caicedo, Andrés

doi:10.1016/j.mito.2022.05.006

Cited by 5 publications

(1 citation statement)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Development and refinement of fertility preservation interventions [21,22]; Initial Development and Validation of Reproductive Technologies (e.g., ICSI, IVF); genetic studies in fertility (Gene Knockout/Overexpression) [23,24]; Research on environmental and lifestyle impact on fertility [25]; Testing emerging technologies (e.g., mitochondrial replacement therapy [26][27][28], gene editing [29])…”

Section: Mice Mammalian Rodentmentioning

confidence: 99%

Bridging the Gap: Animal Models in Next-Generation Reproductive Technologies for Male Fertility Preservation

Aponte,

Gutierrez-Reinoso,

Garcia-Herreros

2023

Life

View full text Add to dashboard Cite

This review aims to explore advanced reproductive technologies for male fertility preservation, underscoring the essential role that animal models have played in shaping these techniques through historical contexts and into modern applications. Rising infertility concerns have become more prevalent in human populations recently. The surge in male fertility issues has prompted advanced reproductive technologies, with animal models playing a pivotal role in their evolution. Historically, animal models have aided our understanding in the field, from early reproductive basic research to developing techniques like artificial insemination, multiple ovulation, and in vitro fertilization. The contemporary landscape of male fertility preservation encompasses techniques such as sperm cryopreservation, testicular sperm extraction, and intracytoplasmic sperm injection, among others. The relevance of animal models will undoubtedly bridge the gap between traditional methods and revolutionary next-generation reproductive techniques, fortifying our collective efforts in enhancing male fertility preservation strategies. While we possess extensive knowledge about spermatogenesis and its regulation, largely thanks to insights from animal models that paved the way for human infertility treatments, a pressing need remains to further understand specific infertility issues unique to humans. The primary aim of this review is to provide a comprehensive analysis of how animal models have influenced the development and refinement of advanced reproductive technologies for male fertility preservation, and to assess their future potential in bridging the gap between current practices and cutting-edge fertility techniques, particularly in addressing unique human male factor infertility.

show abstract