Early events in endothelial flow sensing

Tanaka, Keiichiro; Joshi, Divyesh; Timalsina, Sushma; Schwartz, Martin A.

doi:10.1002/cm.21652

Cited by 36 publications

(39 citation statements)

References 198 publications

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“…Notch activation by FSS requires expression of its ligands on adjacent cells (Sweet et al, 2013;Polacheck et al, 2017), suggesting that FSS amplifies some aspect of this interaction. Consistent with its junctional localization, a number of studies suggest a connection to the junctional mechanosensory complex, consisting of PECAM-1, VE-cadherin and VEGFRs, that mediates an important subset of FSS responses (Tzima et al, 2005;Givens and Tzima, 2016;Tanaka et al, 2021). Chemical inhibition of VEGFR2 reportedly blocks flow activation of Notch (Masumura et al, 2009).…”

Section: Shear Stressmentioning

confidence: 84%

Developmental Perspectives on Arterial Fate Specification

Chen

Schwartz

Simons

2021

Front. Cell Dev. Biol.

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Blood vessel acquisition of arterial or venous fate is an adaptive phenomenon in response to increasing blood circulation during vascular morphogenesis. The past two decades of effort in this field led to development of a widely accepted paradigm of molecular regulators centering on VEGF and Notch signaling. More recent findings focused on shear stress-induced cell cycle arrest as a prerequisite for arterial specification substantially modify this traditional understanding. This review aims to summarize key molecular mechanisms that work in concert to drive the acquisition of arterial fate in two distinct developmental settings of vascular morphogenesis: de novo vasculogenesis of the dorsal aorta and postnatal retinal angiogenesis. We will also discuss the questions and conceptual controversies that potentially point to novel directions of investigation and possible clinical relevance.

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Section: Shear Stressmentioning

confidence: 84%

Developmental Perspectives on Arterial Fate Specification

Chen

Schwartz

Simons

2021

Front. Cell Dev. Biol.

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“…Mechanobiological cues involve wall shear stress, elicited by flow or strain, and tension forces from the ECM and the surrounding cells. These forces are integrated by the cells via the dynamic interactions between, amongst others, integrins, junctional proteins, cytoskeletal rearrangements and growth factor receptors [120]. Interestingly, mechanical cues and BMP signaling cooperate in vascular endothelial cell biology and function in several ways, as earlier established in bone biology [31,121] (Figure 2; number 4).…”

Section: Mechano-transductionmentioning

confidence: 87%

“…Blood vasculature-The importance of mechano-transduction in the (dynamic) regulation of endothelial phenotypes and features is well appreciated in vessel biology [120,121]. Mechanobiological cues involve wall shear stress, elicited by flow or strain, and tension forces from the ECM and the surrounding cells.…”

Section: Mechano-transductionmentioning

confidence: 99%

“…High laminar flow in straight vessel segments provides resistance to atherosclerosis, while lower flow and disturbed flow sensitize the vessel to inflammatory pathways and atherosclerosis. Typically, values for FSS in healthy vessels range from highly pulsatile 1-4 pascals (Pa; 10-40 dynes/cm 2 ) in arteries to 0.1-0.6 Pa with low pulsatility in veins [120]. Interestingly, the expression of some BMP signaling components, such as BMP4, Noggin and Grem1, is regulated by flow.…”

Section: Mechano-transductionmentioning

confidence: 99%

“…Lymphatic vasculature-The lymphatic vasculature is a low-flow system (up to 0.6 Pa) with a very high pulsatility [120]. The lymphatic endothelium is also very sensitive to changes in mechano-transduction.…”

Section: Mechano-transductionmentioning

confidence: 99%

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The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology

Ponomarev

Ksiazkiewicz

Staring

et al. 2021

IJMS

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Bone morphogenetic proteins (BMPs) were originally identified as the active components in bone extracts that can induce ectopic bone formation. In recent decades, their key role has broadly expanded beyond bone physiology and pathology. Nowadays, the BMP pathway is considered an important player in vascular signaling. Indeed, mutations in genes encoding different components of the BMP pathway cause various severe vascular diseases. Their signaling contributes to the morphological, functional and molecular heterogeneity among endothelial cells in different vessel types such as arteries, veins, lymphatic vessels and capillaries within different organs. The BMP pathway is a remarkably fine-tuned pathway. As a result, its signaling output in the vessel wall critically depends on the cellular context, which includes flow hemodynamics, interplay with other vascular signaling cascades and the interaction of endothelial cells with peri-endothelial cells and the surrounding matrix. In this review, the emerging role of BMP signaling in lymphatic vessel biology will be highlighted within the framework of BMP signaling in the circulatory vasculature.

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Electrospun Scaffolds are Not Necessarily Always Made of Nanofibers as Demonstrated by Polymeric Heart Valves for Tissue Engineering

Wang,

Gao,

Zhai

et al. 2024

Adv Healthcare Materials

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In the last 30 years, there have been nearly 60, 000 publications about electrospun nanofibers, but it is still unclear whether nanoscale fibers are really necessary for electrospun tissue engineering scaffolds. The present report puts forward this argument and reveals that compared with electrospun nanofibers, microfibers with diameter of about 3 μm (named as “oligo‐micro fiber” by us) is more appropriate for tissue engineering scaffolds owing to its better cell infiltration ability caused by larger pores with available nuclear deformation. To further increase pore sizes, electrospun poly(ε‐caprolactone) scaffolds were fabricated using latticed collectors with meshes. Fiber orientation led to sufficient mechanical strength albeit increased porosity. The latticed scaffolds exhibited good biocompatibility and improved cell infiltration. Under aortic conditions in vitro, the performances of latticed scaffolds were satisfactory in terms of the acute systolic hemodynamic functionality, except for the higher regurgitation fraction caused by the enlarged pores. This hierarchical electrospun scaffold with sparse fibers in macropores and oligo‐micro fibers in filaments provides new insight into the design of tissue engineering scaffolds, and tissue engineering may provide living heart valves with regenerative capabilities for patients with severe valve disease in the future.This article is protected by copyright. All rights reserved

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Early events in endothelial flow sensing

Cited by 36 publications

References 198 publications

Developmental Perspectives on Arterial Fate Specification

Developmental Perspectives on Arterial Fate Specification

The BMP Pathway in Blood Vessel and Lymphatic Vessel Biology

Electrospun Scaffolds are Not Necessarily Always Made of Nanofibers as Demonstrated by Polymeric Heart Valves for Tissue Engineering

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