Early Epidermal Neoplasia: Description and Interpretation

Sutton, Richard L.

doi:10.1001/archderm.1938.01480110003001

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The Advent Of Aks Reflecting a Continuum To Scc1

Request Respectfully Return To Rudiments1

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1953

2004

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Cited by 18 publications

(2 citation statements)

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“…As early as in 1938, the dermatologist R.L. Sutton Jr. argued against the theory of precancer and discussed why AK is simply a superficial SCC that may in time progress relentlessly to deadly consequences, as is the tendency of all cancers [34].…”

Section: The Advent Of Aks Reflecting a Continuum To Sccmentioning

confidence: 99%

Actinic Keratosis: The Key Event in the Evolution from Photoaged Skin to Squamous Cell Carcinoma

Oppel

Körting²

2004

Skin Pharmacol Physiol

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Skin aging is the result of intrinsic and extrinsic factors. Extrinsic aging, also called photoaging, is mainly caused by ultraviolet radiation from the sun and leads to a state which has been termed dermatoheliosis. The aim of this article is to provide an overview of photoaged skin addressing actinic keratoses (AKs) in particular. This review will describe the clinical features of photoaged skin and briefly summarize the underlying histological, photobiochemical and molecular mechanisms responsible for photoaging. The concept of the disease continuum from AK to squamous cell carcinoma will also be presented. A special focus will be on established and new therapeutic approaches to undo photoinduced skin damage.

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Section: The Advent Of Aks Reflecting a Continuum To Sccmentioning

confidence: 99%

Actinic Keratosis: The Key Event in the Evolution from Photoaged Skin to Squamous Cell Carcinoma

Oppel

Körting²

2004

Skin Pharmacol Physiol

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“….This theory does away completely with the concept of "precancerosis"; there is no such thing. 7 Sutton, a dermatologist, got it right! It is time that pathologists, at long last, caught up with him.…”

Section: Request Respectfully Return To Rudimentsmentioning

confidence: 99%