Early enriched housing results in partial recovery of memory deficits in female, but not in male, rats after neonatal hypoxia–ischemia

Pereira, Lenir Orlandi; Strapasson, Atahualpa Cauê Paim; Nabinger, Patrícia Machado; Achaval, Matilde; Netto, Carlos Alexandre

doi:10.1016/j.brainres.2008.04.010

Cited by 82 publications

(72 citation statements)

References 54 publications

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“…In support of this notion, exposure to enriched environment was effective in recovering declarative but not aversive memory impairment and preserved hippocampal dendritic spine density loss after neonatal HI injury in rats (Rojas et al, 2013). Environmental enrichment, however, did not affect HI-induced tissue atrophy in the hippocampus (Pereira et al, 2008).…”

Section: Accepted M Manuscriptsupporting

confidence: 54%

Intranasal C3a treatment ameliorates cognitive impairment in a mouse model of neonatal hypoxic–ischemic brain injury

Morán

Stokowska

Walker

et al. 2017

Experimental Neurology

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Pekna, M. (2017). Intranasal C3a treatment ameliorates cognitive impairment in a mouse model of neonatal hypoxic-ischemic brain injury. Experimental Neurology. DOI: 10.1016DOI: 10. /j.expneurol.2017 Citing this paper Please note that where the full-text provided on King's Research Portal is the Author Accepted Manuscript or Post-Print version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version for pagination, volume/issue, and date of publication details. And where the final published version is provided on the Research Portal, if citing you are again advised to check the publisher's website for any subsequent corrections. General rightsCopyright and moral rights for the publications made accessible in the Research Portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognize and abide by the legal requirements associated with these rights.•Users may download and print one copy of any publication from the Research Portal for the purpose of private study or research.•You may not further distribute the material or use it for any profit-making activity or commercial gain •You may freely distribute the URL identifying the publication in the Research Portal Take down policy If you believe that this document breaches copyright please contact librarypure@kcl.ac.uk providing details, and we will remove access to the work immediately and investigate your claim. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT

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Section: Accepted M Manuscriptsupporting

confidence: 54%

Intranasal C3a treatment ameliorates cognitive impairment in a mouse model of neonatal hypoxic–ischemic brain injury

Morán

Stokowska

Walker

et al. 2017

Experimental Neurology

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“…Enrichment increases brain-derived neurotrophic factor following brain injury [46,47] , although some studies suggest females may benefit from this more than males [48] . Daily enrichment also prevents spatial memory deficits after adult hypoxia-ischemia [49] and stroke [47,50] , and early housing in an enriched environment prevented some cognitive deficits after neonatal hypoxia-ischemia [51] . Young adult mice develop more differentiating neuroblasts, with increased neuronal survival in the dentate gyrus [52] , and physical activity and enriched environments also increased proliferation of precursor cells in the adult hippocampus [53] .…”

Section: Discussionmentioning

confidence: 99%

Erythropoietin Sustains Cognitive Function and Brain Volume after Neonatal Stroke

Abel²,

Cr³

et al. 2009

Dev Neurosci

118

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Neonatal stroke leads to mortality and severe morbidity, but there currently is no effective treatment. Erythropoietin (EPO) promotes cytoprotection and neurogenesis in the short term following brain injury; however, long-term cognitive outcomes and optimal dosing regimens have not been clarified. We performed middle cerebral artery occlusion in postnatal day 10 rats, which were treated with either a single dose of EPO (5 U/g, i.p.) immediately upon reperfusion, or 3 doses of EPO (1 U/g, i.p. each) at 0 h, 24 h, and 7 days after injury. At 3 months after injury, rats treated with 3 doses of EPO did not differ from shams in the Morris water maze, and generally performed better than either rats treated with a single dose or vehicle-treated injured rats. These multiple-dose-treated rats also had increases in hemispheric volume and its subregions. These results suggest that additional, later doses of EPO may be required for cell repair, proliferation, and long-term incorporation into neural networks after neonatal brain injury.

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“…In contrast, males, but not females, exhibited EE-enhanced spatial memory performance. 89 Given that EE produces many changes in the brain, it seemed unlikely that the EE benefits were confined only to males, particularly because several studies in other CNS injury models, [90][91][92] as well as non-CNS injury paradigms, [93][94][95] have consistently reported that EE induces cognitive benefits in females. Hence, to further address this disparity, Monaco and colleagues 96 set out to reassess the effect of EE on functional and histological outcome in female rats after brain trauma, using similar experimental procedures to the previous study by Wagner and colleagues.…”

Section: The Benefits Of Environmental Enrichment Extend Beyond Adultmentioning

confidence: 99%

Environmental Enrichment as a Viable Neurorehabilitation Strategy for Experimental Traumatic Brain Injury

Bondi

Klitsch

Leary

et al. 2014

Journal of Neurotrauma

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Environmental enrichment (EE) emerged as a robust independent variable capable of influencing behavioral outcome in experimental studies after the fortuitous observation by renowned neuropsychologist Donald O. Hebb that rats raised as pets in his home performed markedly better on problem-solving tasks than those kept in the laboratory. In the subsequent years, numerous studies ensued demonstrating that EE was also capable of inducing neuroplasticity in normal (i.e., noninjured) rats. These behavioral and neural alterations provided the impetus for investigating EE as a potential therapy for traumatic brain injury (TBI), which, over the past two decades, has resulted in several reports. Hence, the aim of this review is to integrate the findings and present the current state of EE as a viable neurorehabilitation strategy for TBI. Using the specific key term searches ''traumatic brain injury'' and ''environmental enrichment'' or ''enriched environment,'' 30 and 30 experimental TBI articles were identified by PubMed and Scopus, respectively. Of these, 27 articles were common to both search engines. An additional article was found on PubMed using the key terms ''enriched environment'' and ''fluid percussion.'' A review of the bibliographies in the 34 articles did not yield additional citations. The overwhelming consensus of the 34 publications is that EE benefits behavioral and histological outcome after brain injury produced by various models. Further, the enhancements are observed in male and female as well as adult and pediatric rats and mice. Taken together, these cumulative findings provide strong support for EE as a generalized and robust preclinical model of neurorehabilitation. However, to further enhance the model and to more accurately mimic the clinic, future studies should continue to evaluate EE during more rehabilitation-relevant conditions, such as delayed and shorter time periods, as well as in combination with other therapeutic approaches, as we have been doing for the past few years.

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Early enriched housing results in partial recovery of memory deficits in female, but not in male, rats after neonatal hypoxia–ischemia

Cited by 82 publications

References 54 publications

Intranasal C3a treatment ameliorates cognitive impairment in a mouse model of neonatal hypoxic–ischemic brain injury

Intranasal C3a treatment ameliorates cognitive impairment in a mouse model of neonatal hypoxic–ischemic brain injury

Erythropoietin Sustains Cognitive Function and Brain Volume after Neonatal Stroke

Environmental Enrichment as a Viable Neurorehabilitation Strategy for Experimental Traumatic Brain Injury

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