Early effects of statin therapy on endothelial function and microvascular reactivity in patients with coronary artery disease

Ling, Michael C; Ruddy, Terrence D.; deKemp, Robert A.; Ukkonen, Heikki; Duchesne, Lloyd; Higginson, Lyall; Williams, Kathryn; McPherson, Ruth; Beanlands, Rob

doi:10.1016/j.ahj.2005.02.033

Cited by 34 publications

(20 citation statements)

References 21 publications

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“…However, FMD alterations in CAD patients (control group), three month after drug treatment and diet, remained down and after 8 weeks too lowly. Our results agree with medical therapy (statin) after 10 weeks faield to improve endothelium-dependent function in CAD patients [20] but it is unconvienced with Ling and et al, short term simvastatin therapy increases endothelial function in patients with stable CAD [21]. Furthermore, the exercises considers as method of intervention in cardiac rehabilitation and vascular disease.…”

Section: Discussionsupporting

confidence: 81%

The effect of aerobic training on endothelium-dependent vasodilatation in patients with coronary artery disease who were revascularized and young men

Seyedian¹,

Ahmadi²,

Hamidian³

et al. 2013

Health

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Aim: The aim of this study was to determine the effect of training on endothelium-dependent vasodilatation in patients with coronary artery disease (CAD) after revascularization and healthy young men. Background: Impaired endothelial function has been observed in patients with CAD and those with CAD risk factors. Studies have shown that exercise can enhance endothelial function. Methods: This experimental crosssectional study was conducted on patients with CAD (3 months after CABG and PCI) and students of medical school in 2011. Endothelium dependent dilation of the brachial artery was determined by using high-resolution vascular ultrasonography through flow-mediated vasodilatation (FMD) after induction of ischemia, and the data were analyzed using SPSS, dependent ttest and ANCOVA. Findings: The findings showed that at baseline, FMD was reduced in revascularized patients, when compared with healthy young men, after 8 weeks, and exercise training significantly improved FMD in patients underwent training group [from 4.31 ± 1.45 (SD)% to 6.15 ± 0.773 (SD)%, p < 0.05] and substantially increased the same in healthy young men [from 9.18% ± 1.45% to 11.72% ± 1.72%, p < 0.05] However, in the control group, the FMD remained unchanged, and even after aerobic training, it did not significantly modify the brachial artery diameter in these groups. Conclusion: Our study demonstrates that endothelial dysfunction persisting in CAD patients after revascularization and aerobic training can improve endothelial function in different vascular beds in CAD patients and healthy young men. This may contribute to the benefit of regular exercise in preventing and restricting cardiovascular disease.

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Section: Discussionsupporting

confidence: 81%

The effect of aerobic training on endothelium-dependent vasodilatation in patients with coronary artery disease who were revascularized and young men

Seyedian¹,

Ahmadi²,

Hamidian³

et al. 2013

Health

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“…17 In addition, it is suggested that improvement of myocardial vascular function by statins is not only a result of reduction in plasma lipid fractions but is also caused by some action on blood vessels other than a lipid-lowering effect (pleiotropic effects). 5 Ling et al 18 recently showed that statin therapy improved peripheral endothelial function at 8 weeks. Hinoi et al 19 revealed the potent vasorelaxing effects of atorvastatin treatment on coronary microvessels of the normal coronary artery in patients without coronary artery disease by angiography.…”

Section: Discussionmentioning

confidence: 99%

Effects of Atorvastatin on Coronary Flow Reserve in Patients with Slow Coronary Flow

Çalışkan

Erdoğan

Güllü

et al. 2007

Clinical Cardiology

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Background Statins improve endothelial functioning in patients with coronary artery disease and hypercholesterolemia, while substantially little is known about induced changes in myocardial microcirculation. However, although previous studies have suggested that microvascular abnormalities and endothelial dysfunction is responsible for slow coronary flow (SCF), there is no study investigating possible effects of statins on coronary microvascular function in patients with SCF. Hypothesis We prospectively investigated the effects of short‐term lipid‐lowering therapy with atorvastatin on coronary flow reserve (CFR) reflecting coronary microvascular function in patients with SCF assessed by transthoracic Doppler echocardiography (TTDE). Methods In an open clinical trial, CFR was studied in 20 subjects with SCF. TTDE was used to assess CFR at baseline as well as after 8 weeks of atorvastatin therapy. Coronary flow was quantified according to TIMI frame count (TFC). Coronary diastolic peak flow velocities were measured at baseline and after dipyridamole infusion. CFR was calculated as the ratio of hyperemic to baseline diastolic peak velocities. Results CFR was independently correlated with TFC. After 8 weeks of atorvastatin therapy, CFR values increased significantly (1.95 ± 0.38 vs. 2.54 ± 0.56, (p < 0.001). No change in hemodynamic parameters was noted during the entire study. The improvement in CFR was not correlated to the amount of lipid‐lowering effect of atorvastatin. Conclusions These findings suggest that short‐term lipid‐lowering therapy with atorvastatin improved CFR, which reflects coronary microvascular functioning in patients with SCF. Copyright © 2007 Wiley Periodicals, Inc.

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“…plaques, decreasing oxidative stress and inflammation, and inhibiting the thrombogenic response [16]. Therefore, statins are suggested in the treatment of CSF syndrome [17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Relationship Between Angiographic Coronary Slow Flow Phenomenon and Subfoveal Choroidal Thickness: What is The Effect of Atorvastatin Therapy?

Kanar¹,

Kanar²

2018

Eur J Exp Bio

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Objective: Although the pathophysiological mechanisms underlying coronary slow flow (CSF) phenomenon still remains uncertain, the microvascular dysfunction has been first implicated. The CSF phenomenon may not only affect the coronary arteries but it may also be a part of vascular problem that affect other arteries. The aim of the present study is to evaluate the relationship between CSF phenomenon and subfoveal choroidal thickness (SFCT) and to investigate the effect of short-term atorvastatin therapy on SFCT in patients with CSF. Methods:The study population consisted of 48 patients with CSF and 41 healthy control participants. Coronary flow patterns of the patients were determined by thrombolysis in myocardial infarction (TIMI) frame count method. Spectral-domain optical coherence tomography (SD-OCT) measurements of SFCT and lipid parameters were obtained before and after 2 weeks of daily single dose of 80 mg atorvastatin therapy. Results:We found that patients with CSF had thinner SFCT compared with control group. There was a significant negative correlation between mean TIMI frame count and baseline SFCT (r=-0.69, p=0.001). ROC curve analysis revealed that SFCT <259 m predicted CSF with a 85% sensitivity and 88% specificity. The SFCT significantly increased after the short-term atorvastatin therapy. Conclusion:There was a close negative correlation between CSF phenomenon and SFCT. Endothelial dysfunction (ED) and the resultant microvascular dysfunction might be operative on both coronary and ocular choriocapillary arteries in patients with CSF. Increase of SFCT after the short-term atorvastatin therapy might be an indicator of microvascular dysfunction improvement in patients with CSF.

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Early effects of statin therapy on endothelial function and microvascular reactivity in patients with coronary artery disease

Cited by 34 publications

References 21 publications

The effect of aerobic training on endothelium-dependent vasodilatation in patients with coronary artery disease who were revascularized and young men

The effect of aerobic training on endothelium-dependent vasodilatation in patients with coronary artery disease who were revascularized and young men

Effects of Atorvastatin on Coronary Flow Reserve in Patients with Slow Coronary Flow

Relationship Between Angiographic Coronary Slow Flow Phenomenon and Subfoveal Choroidal Thickness: What is The Effect of Atorvastatin Therapy?

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