Early effects of diquat on plasma corticosteroid concentrations in rats

Crabtree, Helen C.; Rose, Michael S.

doi:10.1016/0006-2952(76)90449-4

Cited by 5 publications

(1 citation statement)

References 8 publications

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“…Protein carbonyl groups are another indicator of oxidative stress, and the carbonyl levels in plasma are commonly used to measure oxidative injury (Levine et al 1990;Shacter et al 1994). In addition, Crabtree and Rose (1976) reported that plasma corticosteroid concentrations were significantly elevated after intraperitoneal injection of 90 lmoles of diquat kg À1 body weight into phenobarbitone anaesthetized rats and suggested that this increase was also indicative of oxidative stress. In the present study, both carbonyl and cortisol were significantly increased in the plasma of diquat-treated piglets.…”

Section: Discussionmentioning

confidence: 99%

Dietary supplementation with Lactobacillus fermentum I5007 improves the anti-oxidative activity of weanling piglets challenged with diquat

et al. 2013

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Aims: To determine the effects of Lactobacillus fermentum I5007 on the redox state of piglets oxidatively stressed with diquat. Methods and Results: Twenty-four, 28-day-old barrows were used in a 2 9 2 factorial design experiment with the main effects being Lact. fermentum supplementation and diquat challenge. Half of the pigs (n = 12) were orally administered with 20 ml of a solution containing 10 8 CFU ml À1 ofLact. fermentum each morning of the 21-day trial, while the remainder received saline. On day 8, these two groups were further subdivided so that half of the pigs in each group (n = 6) were intraperitoneally injected with 10 mg kg À1BW diquat, while the remainder received saline. The diquat-injected pigs had significantly poorer performance and increased levels of plasma cortisol, adrenaline, carbonyl and malondialdehyde. Lactobacillus fermentum supplementation significantly increased superoxide dismutase and glutathione and increased the ability to inhibit superoxide anion production in liver and muscle. Conclusions: Lactobacillus fermentum improved the anti-oxidative defence system and alleviated damage caused by diquat. Significance and Impact of the Study: Lactobacillus fermentum has the potential to alleviate oxidative stress and improve weaning pig performance.

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Section: Discussionmentioning

confidence: 99%

Dietary supplementation with Lactobacillus fermentum I5007 improves the anti-oxidative activity of weanling piglets challenged with diquat

et al. 2013

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Investigation of Adrenal Steroids and 25-Hydroxy-cholecalcipherol in Human Gramoxone Poisoning

Bársony

Kertész²

1985

Archives of Toxicology

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Imaging Findings and Toxicological Mechanisms of Nervous System Injury Caused by Diquat

Ren,

Guo,

Wang

2024

Mol Neurobiol

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Diquat (DQ) is a nonselective bipyridine herbicide with a structure resembling paraquat (PQ). In recent years, the utilization of DQ as a substitute for PQ has grown, leading to an increase in DQ poisoning cases. While the toxicity mechanism of DQ remains unclear, it is primarily attributed to the intracellular generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) through the process of reduction oxidation. This results in oxidative stress, leading to a cascade of clinical symptoms. Notably, recent reports on DQ poisoning have highlighted a concerning trend: an upsurge in cases involving neurological damage caused by DQ poisoning. These patients often present with severe illness and a high mortality rate, with no effective treatment available thus far. Imaging findings from these cases have shown that neurological damage tends to concentrate on the brainstem. However, the specific mechanisms behind this poisoning remain unclear, and no specific antidote exists. This review summarizes the research progress on DQ poisoning and explores potential mechanisms. By shedding light on the nerve damage associated with DQ poisoning, we hope to raise awareness, propose new avenues for investigating the mechanisms of DQ poisoning, and lay the groundwork for the development of treatment strategies for DQ poisoning. Trial registration number: 2024PS174K.

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Early effects of diquat on plasma corticosteroid concentrations in rats

Cited by 5 publications

References 8 publications

Dietary supplementation with Lactobacillus fermentum I5007 improves the anti-oxidative activity of weanling piglets challenged with diquat

Dietary supplementation with Lactobacillus fermentum I5007 improves the anti-oxidative activity of weanling piglets challenged with diquat

Investigation of Adrenal Steroids and 25-Hydroxy-cholecalcipherol in Human Gramoxone Poisoning

Imaging Findings and Toxicological Mechanisms of Nervous System Injury Caused by Diquat

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