Abstract:Doxorubicin (DOX) is an effective chemotherapeutic agent, but known to cause cardiotoxicitv via induction of oxidative stress and apoptosis. DOX also causes hepatic toxicity, although mechanisms have not been as extensively described. Currently, the mechanism of DOX induced hepatic apoptosis is unknown. Moreover, despite the anorexic effects of DOX very few studies have controlled for this and, therefore, it is not clear whether changes in apoptosis markers and signaling in vivo are due to direct or indirect e… Show more
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