Early drop of LV ejection fraction can predict trastuzumab-related cardiotoxicity in patients with breast cancer

Abstract

calculated for all patients using standard DVH. Base line thyroid function test and clinical assessment was done before radiation therapy. All patients were treated with 50Gy in 25 fractions (Conventional arm) or 40Gy in 15 fractions (Hypo fractionated arm) to chest wall and SCF. After therapy, TFT and clinical evaluation were done at every 3 months interval for a year. Results: Mean thyroid volume was found to be 10.3cc. Mean dose received by thyroid gland was 47.5Gy in Conventional arm and 38Gy in Hypo fractionated arm. The V20, V30, V40 and V50 of thyroid gland in the Conventional arm were 60.6, 56.5, 53.3 and 35.2%. Mean TSH change between baseline and 1 year was 40.9% in Conventional arm and 35.2% in Hypo fractionated arm.