Early disturbance of dynamic synchronization and neurovascular coupling in cognitively normal Parkinson’s disease

Shang, Shaobin; Ye, Jing; Wu, Jingtao; Zhang, Hongying; Dou, Weiqiang; Muthaiah, Vijaya Prakash Krishnan; Tian, You‐Yong; Zhang, Yingdong; Chen, Yu‐Chen; Yin, Xindao

doi:10.1177/0271678x221098503

Cited by 15 publications

(9 citation statements)

References 59 publications

(79 reference statements)

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“…It requires collaboration among many components in the brain, including neurons, glial cells, smooth muscle cells, and endothelial cells. Any impairment in these components can lead to an abnormal NVC, affecting homeostasis (Guo et al., 2019; Li et al., 2021; Shang et al., 2022; Zhu et al., 2022). Generally, NVC in a healthy brain actively regulates the blood supply according to the local neuronal activity intensity, maintaining a relatively stable microenvironment for neurons.…”

Section: Discussionmentioning

confidence: 99%

Altered neurovascular coupling in migraine without aura

Zhou,

Zhang,

et al. 2024

J of Neuroscience Research

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Neurovascular coupling (NVC) provides new insights into migraine, a neurological disorder impacting over one billion people worldwide. This study compared NVC and cerebral blood flow (CBF) in patients with migraine without aura (MwoA) and healthy controls. About 55 MwoA patients in the interictal phase and 40 age‐ and sex‐matched healthy controls underwent resting‐state functional magnetic resonance imaging and arterial spin‐labeling perfusion imaging scans. The CBF and resting‐state neuronal activity indicators, including the amplitudes of low‐frequency fluctuation (ALFF), regional homogeneity (ReHo), and degree centrality (DC), were calculated for each participant. The global and regional NVCs were assessed using cross‐voxel CBF‐neuronal activity correlations and CBF/neuronal activity ratios. Patients with MwoA showed increased CBF/ALFF ratios in the left media, superior and inferior frontal gyri, and anterior cingulate gyrus, increased CBF/DC ratios in the left middle and inferior frontal gyri, and increased CBF/ReHo ratios in the right corpus callosum and right posterior cingulate gyrus. Lower CBF/ALFF ratios in the right rectal gyrus, the left orbital gyrus, the right inferior frontal gyrus, and the right superior temporal gyrus were also found in the MwoA patients. Furthermore, the CBF/ALFF ratios in the inferior frontal and superior temporal gyri were positively correlated with the Headache Impact Test scores and Hamilton anxiety scale scores in the MwoA patients. These findings provide evidence for the theory that abnormal NVC contributes to MwoA.

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Section: Discussionmentioning

confidence: 99%

Altered neurovascular coupling in migraine without aura

Zhou,

Zhang,

et al. 2024

J of Neuroscience Research

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“…Our findings showed abnormal temporal property of local neural activity in the visual, sensorimotor, and cognitive systems in PD, which was consistent with the previous studies. For example, the previous fMRI studies that calculated the variability of brain signal across time found abnormal variance in visual [47][48][49] , sensorimotor 47,50 , and frontal 51,52 regions in PD. Some studies also found that the symptom severity of PD significantly correlated with such abnormal variability in the visual and sensorimotor regions.…”

Section: Discussionmentioning

confidence: 99%

Abnormal intrinsic neural timescale and reduced grey matter volume in Parkinson’s disease

Wei

Zhang

Peng

et al. 2022

Preprint

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Background: The intrinsic neural timescale in a local brain area has been specialized, and the sensory and prefrontal areas have shorter and longer timescales, respectively. Parkinson's disease (PD) is a progressive neurological disorder that also exhibits with abnormal neural activity in sensorimotor, visual, and cognitive-related areas. However, it was unclear whether PD patients exhibited abnormal intrinsic timescales and whether PD patients exhibited different temporal feature at different stages. Methods: Here, we estimated the intrinsic timescales using the magnitude of the autocorrelation of intrinsic neural signals by resting state functional magnetic resonance imaging data in 74 PD patients, including 44 patients in the early stage (PD-ES) and 30 patients in the late stage (PD-LS), and 73 healthy controls (HC). Results: We identified that the PD group had shorter timescales in bilateral lingual and calcarine gyri, bilateral postcentral and precentral gyri, and the right middle cingulum gyrus than the HC group, which correlated with the age, but not in the HC group. Moreover, shorter timescales in the PD group also correlated with the symptom severity and reduced grey matter volume (GMV). Longer timescale in the right middle frontal gyrus was also found in the PD group than that in the HC group. Increasingly, compared to the HC group, the PD-ES group had longer timescales in the anterior cortical regions, including the left superior and inferior frontal gyri, and the right middle frontal gyrus, whereas the PD-LS group had shorter timescales in the posterior cortical regions, including bilateral calcarine and lingual gyri, which accompanied with more serious cognitive impairments and reduced GMV. Conclusions: Our findings suggest that PD patients exhibit abnormal intrinsic timescales in visual, sensorimotor, and cognitive systems, which might provide new insights for the neural substrate of PD. Distinct patterns of intrinsic timescales in cerebral cortex between the PD-LS and PD-ES groups indicate that intrinsic timescale might be a new neuroimaging biomarker across disease stage in PD.

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“…ReHo primarily measures the temporal synchrony of regional neural activity between spatially adjacent regions ( 22 ), and dReHo reflects the change in similarity between the time series of a specific voxel and its nearest neighbors ( 42 , 43 ). Patients with TA had increased dReHo values in the Left superior temporal gyrus, middle frontal gyrus, precentral gyrus, precuneus, angular gyrus, right superior frontal gyrus, middle temporal gyrus, postcentral gyrus, middle frontal gyrus.…”

Section: Discussionmentioning

confidence: 99%

Dynamic local metrics changes in patients with toothache: A resting-state functional magnetic resonance imaging study

Wang

Tang²,

Li³

et al. 2022

Front. Neurol.

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ObjectiveTo study the dynamic changes of local metrics in patients with toothache (TA, Toothache) in the resting state, in order to further understand the changes of central neural mechanism in patients with dental pain and its effect on cognition and emotion.MethodsThirty patients with TA and thirty matched healthy (HC) control volunteers were recruited, and resting-state functional magnetic resonance (rs-MRI) scans were performed on all subjects, and data were analyzed to compare group differences in three dynamic local indices: dynamic regional homogeneity (dReHO), dynamic low-frequency fluctuation amplitude (dALFF) and dynamic fractional low-frequency fluctuation amplitude (dfALFF). In addition, the association between dynamic local metrics in different brain regions of TA patients and scores on the Visual Analog Scale (VAS) and the Hospital Anxiety and Depression Scale (HADS) was investigated by Pearson correlation analysis.ResultsIn this study, we found that The local metrics of TA patients changed with time Compared with the HC group, TA patients showed increased dReHo values in the left superior temporal gyrus, middle frontal gyrus, precentral gyrus, precuneus, angular gyrus, right superior frontal gyrus, middle temporal gyrus, postcentral gyrus and middle frontal gyrus, increased dALFF values in the right superior frontal gyrus, and increased dfALFF values in the right middle temporal gyrus, middle frontal gyrus and right superior occipital gyrus (p < 0.01, cluster level P < 0.05). Pearson correlation analysis showed that dReHo values of left precuneus and left angular gyrus were positively correlated with VAS scores in TA group. dReHo value of right posterior central gyrus was positively correlated with HADS score (P < 0.05).ConclusionThere are differences in the patterns of neural activity changes in resting-state brain areas of TA patients, and the brain areas that undergo abnormal changes are mainly pain processing brain areas, emotion processing brain areas and pain cognitive modulation brain areas, which help to reveal their underlying neuropathological mechanisms. In the hope of further understanding its effects on cognition and emotion.

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Early disturbance of dynamic synchronization and neurovascular coupling in cognitively normal Parkinson’s disease

Cited by 15 publications

References 59 publications

Altered neurovascular coupling in migraine without aura

Altered neurovascular coupling in migraine without aura

Abnormal intrinsic neural timescale and reduced grey matter volume in Parkinson’s disease

Dynamic local metrics changes in patients with toothache: A resting-state functional magnetic resonance imaging study

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