Early Dietary Antigens Delay the Development of Gut Mucosal Barrier in Preweaning Rats

Arvola, Taina; Rantala, Immo; Marttinen, A.; Isolauri, Erika

doi:10.1203/00006450-199209000-00011

Cited by 31 publications

(12 citation statements)

References 18 publications

(22 reference statements)

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“…Moreover, mothers' milk may be an important factor in this programming. The intestine of a rat remains open to the uptake of maternal milk-derived macromolecules until the age of 21 days, when intestinal permeability decreases to the adult level [ 31 ]. However, in our studies the relationships between maternal hormones in milk and their concentration in the blood plasma of their offspring were observed only for ghrelin in HFO on the 14th day of lactation.…”

Section: Discussionmentioning

confidence: 99%

Maternal High-Fat Diet during Pregnancy and Lactation Influences Obestatin and Ghrelin Concentrations in Milk and Plasma of Wistar Rat Dams and Their Offspring

Słupecka

Romanowicz

Woliński

2016

International Journal of Endocrinology

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The study aims to establish the effect of a maternal high-fat diet on obestatin concentration, total ghrelin, and ghrelin/obestatin ratio during pregnancy and lactation of Wistar rats and their offspring in the first 21 days of life. On the mating day, females were randomly allocated and fed either a high-fat diet (30% of fat; HF) or breeding diet (5% fat; BD) till the 21st day of lactation. Hormones were analyzed in the blood plasma and milk of rat dams as well as in the blood plasma of their offspring. HF resulted in a significant decrease in obestatin level on the 14th day of lactation and elevation on the 21st day. Plasma obestatin in HFD offspring was significantly higher than in BD ones. HF diet did not significantly affect dam plasma ghrelin until the 21st day of lactation. The ghrelin concentrations in milk after both diets were significantly lower than in blood plasma. Milk ghrelin in HF dams was significantly higher than in the BD ones. Plasma ghrelin from HF offspring was significantly higher than that from BD dams. Our results demonstrate that a maternal HF diet during pregnancy and lactation influences ghrelin and obestatin level in both dams and their offspring.

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Section: Discussionmentioning

confidence: 99%

Maternal High-Fat Diet during Pregnancy and Lactation Influences Obestatin and Ghrelin Concentrations in Milk and Plasma of Wistar Rat Dams and Their Offspring

Słupecka

Romanowicz

Woliński

2016

International Journal of Endocrinology

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“…In rats, this occurs at weaning around the age of 21 days, while it has been suggested to be completed within 20 days after birth in humans . The process of GIB maturation can also be influenced by gastric intrinsic factors, hormones, growth factors, diet, as well as early colonizing gut microbiota …”

Section: Introductionmentioning

confidence: 99%

Impact of dietary induced precocious gut maturation on cecal microbiota and its relation to the blood‐brain barrier during the postnatal period in rats

Marungruang

Sureda

Lefrançoise

et al. 2018

Neurogastroenterology Motil

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“…Furthermore, our data suggest that early introduction of not only cow's milk but also complementary food might be associated with IgAN development. The main point is sensitization of systemic IgA immune system before the full development of the intestinal barrier by early introduction of antigenic food, which renders this system hyperresponsive to subsequent infectious or other dietary antigens [4]. This sensitization is related to increased intestinal intraepithelial lymphocytes and monocyte/macrophages and decreased J-chain-producing plasma cells, which are considered markers of breakdown of oral tolerance, allowing an increase in the penetration of luminal antigens [17,18].…”

Section: Discussionmentioning

confidence: 98%

“…Whereas early administration of antigenic foods slows the maturation of gut permeability, breast-feeding (BF) accelerates its closure [4]. Thus, it has been recommended that infants with cow's-milk allergy or infants at such a risk should be given breast milk or, if that is not possible, hydrolyzed formula [5].…”

Section: Introductionmentioning

confidence: 99%

Does feeding in infancy effect the development of IgA nephropathy?

et al. 2007

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Gut permeability to antigens is immature at birth, and while early administration of antigenic foods delays its maturation, breast-feeding accelerates it. We aimed to evaluate whether exposure to antigenic foods in early life is associated with a predisposition for immunoglobulin A nephropathy (IgAN). Three groups of children with IgAN (group 1), non-IgA glomerulopathies (group 2), and healthy controls (group 3) were formed. Parents filled out a questionnaire regarding gestational and postnatal ages, birth weight, and feeding by breast milk, formula, cow's milk, and complementary foods. All groups were similar for age, gender, birth weight, rate and duration of breast-feeding, and rate of formula feeding. Cow's milk consumption rate was higher in groups 1 and 2 than in group 3. Whereas introduction of formula was earlier in groups 1 and 2 than in group 3, feeding by cow's milk and weaning were earlier in group 1 than in the other groups. The respective best cutoff ages were 3.5 [odds ratio (OR) 28)], 3.75 (OR 5.7), and 5.5 (OR 10.5) months for formula, cow's milk, and complementary foods, respectively, for predicting the presence of IgAN. The results of this preliminary study indicate that early introduction of antigenic foods might increase the risk of future primary IgAN.

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Early Dietary Antigens Delay the Development of Gut Mucosal Barrier in Preweaning Rats

Abstract: ABSTRACT. To determine the effects of early antigen exposure on the maturation of the gastrointestinal mucosal barrier, rat pups were divided into three groups at the age of 14 d. In addition to normal maternal milk, group CM (n

Cited by 31 publications

References 18 publications

Maternal High-Fat Diet during Pregnancy and Lactation Influences Obestatin and Ghrelin Concentrations in Milk and Plasma of Wistar Rat Dams and Their Offspring

Maternal High-Fat Diet during Pregnancy and Lactation Influences Obestatin and Ghrelin Concentrations in Milk and Plasma of Wistar Rat Dams and Their Offspring

Impact of dietary induced precocious gut maturation on cecal microbiota and its relation to the blood‐brain barrier during the postnatal period in rats

Does feeding in infancy effect the development of IgA nephropathy?

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