Early diagnosis of tuberculosis by fibreoptic bronchoscopy

Fujii, Hiromi; Ishihara, Jun; Fukaura, Asato; Kashima, Naoko; Tazawa, Hideki; Nakajima, Hideo; Ide, Hiroshi; Takahashi, Tsuyoshi

doi:10.1016/0962-8479(92)90151-9

Cited by 31 publications

(20 citation statements)

References 6 publications

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“…In patients with proven pulmonary TB, bronchial and brush biopsies show typical granulomata in 3.84–53% of cases 206 219 224. Post-bronchoscopy sputum is culture positive in 14–46% of patients and sputum should be cultured if the patient is able to provide an adequate sample 207 208…”

Section: Sampling and Diagnostic Accuracymentioning

confidence: 99%

British Thoracic Society guideline for diagnostic flexible bronchoscopy in adults: accredited by NICE

Rand

Blaikley

Booton

et al. 2013

Thorax

683

735

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Section: Sampling and Diagnostic Accuracymentioning

confidence: 99%

British Thoracic Society guideline for diagnostic flexible bronchoscopy in adults: accredited by NICE

Rand

Blaikley

Booton

et al. 2013

Thorax

683

735

View full text Add to dashboard Cite

“…After the availability of fibre-optic bronchoscope (FOB) in 1968, there has been many studies performed for early diagnosis of TB and many advances has occurred in FOB techniques [11,12]. The combined yield reported in majority of the studies varies from 48-100% as shown in [13,14] (Table 1).…”

Section: Resultsmentioning

confidence: 99%

Comparison of Induced Sputum and Fibre-Optic Bronchoscopy (Fob) in the Early Diagnosis of Sputum Smear Negative Suspected Cases of Pulmonary Tuberculosis under Rntcp Settings-A Study Conducted in Southern Part of Rajasthan

Luhadia¹,

Kapur²,

Luhadia³

et al. 2017

J Pulm Respir Med

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“…In the previous studies by Charoenratanakul et al .,[23] Fujii et al . [24] and Chawla et al .,[25] positive BW/BL results ranged from 25% to 72%. Some of the studies also included post bronchoscopy sputum and cultures, which made the result increase up to 90%.…”

Section: Discussionmentioning

confidence: 99%

Induced sputum versus bronchial washings in the diagnosis of sputum negative pulmonary tuberculosis

Rao

Mandava

Rani

et al. 2016

J Family Med Prim Care

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Introduction:Tuberculosis (TB) is one of the most important public health problems worldwide. Detecting patients with active pulmonary TB (PT) is an important component of TB control programs. However, at times in patients even with a compatible clinical picture, sputum smears do not reveal acid-fast bacilli (AFB) and smear-negative PT remains a common problem. This study compares the results of induced sputum (IS) and bronchial washings (BWs) in detecting sputum negative PT.Materials and Methods:A prospective study conducted from June 2014 to June 2015, comprising 120 patients fulfilling study criteria. Patients with respiratory symptoms and chest roentgenogram suspicious of PT with no previous history of antiTB treatment (ATT) and two spontaneous sputum smear samples negative for AFB were included in the study. Patients with active hemoptysis and sputum positive were excluded from the study. Sputum induction was done using 5–10 ml of 3% hypertonic saline through ultrasonic nebulizer taking safety precautions. All the patients underwent fiberoptic bronchoscopy after 6 h fasting on the same day. About 20 ml of normal saline instilled into the suspected pathology area and washings were taken with gentle suction. The sample processing and fluorescent staining for AFB were done in a designated microscopy laboratory.Results:Of 120 smear-negative PT patients, IS smear examination detected AFB in 76 patients (63.3%) and AFB detected from BWs in 94 patients (78.5%). Smear positivity higher in cavitary and infiltrative lesions compared to consolidation and infrahilar pattern disease.Conclusions:Even though both IS and BWs procedures were valuable for the diagnosis of smear-negative TB, sputum induction with hypertonic saline should be the initial procedure of choice, which can be repeated twice/thrice in a day or 2 consecutive days. If the patient remains IS smear-negative and if the clinical probability of TB is high, starting ATT and closely monitoring patient and reserving bronchoscopy to those patients who do not improve and to exclude alternative diagnosis seems to be a practically useful approach.

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Early diagnosis of tuberculosis by fibreoptic bronchoscopy

Cited by 31 publications

References 6 publications

British Thoracic Society guideline for diagnostic flexible bronchoscopy in adults: accredited by NICE

British Thoracic Society guideline for diagnostic flexible bronchoscopy in adults: accredited by NICE

Comparison of Induced Sputum and Fibre-Optic Bronchoscopy (Fob) in the Early Diagnosis of Sputum Smear Negative Suspected Cases of Pulmonary Tuberculosis under Rntcp Settings-A Study Conducted in Southern Part of Rajasthan

Induced sputum versus bronchial washings in the diagnosis of sputum negative pulmonary tuberculosis

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