Early diagnosis of renal dysfunction in hypertensive patients with type 2 diabetes mellitus

Біловол, Олександр Миколайович; Kniazkova, I. I.; Kirienko, O. M.; Korniichuk, Vladyslav. I.; Kirienko, D. A.; Абрамова, Л.П.; Berezin, Alexander Е.

doi:10.51847/j2_3l-b

Cited by 2 publications

(3 citation statements)

References 21 publications

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“…In the SAVOR-TIMI 53 study, saxagliptin significantly reduces UACR compared to placebo, primarily driven by the microalbuminuria reduction effect, despite no association between improved UACR and HbA1c [18,19]. Besides, the incidence of UACR headway was considerably decreased with saxagliptin in comparison to placebo in all DKD patients apart from those with extreme kidney damage [10,19,20].…”

Section: The Potential Renal Protection Site Of Dpp-4 Inhibitors In Type-2 Diabetes Mellitusmentioning

confidence: 99%

“…Additional mechanisms of DPP-4 inhibitors include reduction in gastrointestinal motility and slowing of gastric emptying [8]. Because incretins secretion is glucose-dependent, DPP-4 inhibitors are not expected to induce hypoglycemia in the fasting status [9,10]. In trials comparing DPP-4 inhibitors to placebo, it was associated with a slight weight increase of 0.5kg [9].…”

Section: Introduction To Dpp-4 Inhibitorsmentioning

confidence: 99%

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The Role of DPP-4 Inhibitors in Type-2 Diabetes Patients with Chronic Kidney Disease

Alqurashi¹,

Alharthi²,

Alshehri³

et al. 2021

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The most popular type of diabetes is Type-2 diabetes mellitus (T2DM) accounting for 90-95% of diagnosed diabetes and continues to overgrow worldwide and in the USA. This rapid growth may be attributed to the increased elderly population, prevalence of obesity among adults and children, socioeconomic development, urbanization, unhealthy diets, and poor physical activities. The administration of antidiabetic agents in addition to cardio-renal protection is strongly required. Adequate glycemic control must be achieved with protection against cardiovascular and renal outcomes simultaneously. DPP-4 inhibitors are novel antidiabetic agents that have recently demonstrated protection against macro and macrovascular diabetes complications, particularly cardio-renal protection. To evaluate the efficacy and safety of DPP-4 inhibitors on chronic kidney disease patients. We used the PubMed database and searched for relevant articles on the topic. We used the Mesh word searching system; DPP-4 inhibitors; complications; adverse reactions. Type-2 Diabetes mellitus; Chronic kidney disease. DPP-4 inhibitors have demonstrated promising renal protection in healthy animal studies. Nevertheless, in humans with type-2 diabetes mellitus, the renal impact is still controversial. Several randomized clinical trials support the renoprotection effect of diabetic nephropathy.

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Section: The Potential Renal Protection Site Of Dpp-4 Inhibitors In Type-2 Diabetes Mellitusmentioning

confidence: 99%

Section: Introduction To Dpp-4 Inhibitorsmentioning

confidence: 99%

The Role of DPP-4 Inhibitors in Type-2 Diabetes Patients with Chronic Kidney Disease

Alqurashi¹,

Alharthi²,

Alshehri³

et al. 2021

Pharmacophore

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“…Some investigations have indicated that the prevalence of renal colic is around one percent, but other studies have indicated that the rate might range anywhere from one percent to five percent [3][4][5][6] . Acute renal colic is characterized by a rapid onset of flank pain that radiates down into the lower abdomen [7][8][9] . This symptom is typically accompanied by microscopic hematuria, nausea, and vomiting 7 .…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of clinical signs and CT-scan findings in renal colic patients referred to emergency department of Imam hospital in sari in 2021

Golikhatir

Tahereh

Sazgar

et al. 2022

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Background: The aim of this study was to investigate the positive predictive value of CT scan findings and clinical signs in choice of clinical management of renal colic patients referred to the emergency department of Imam Hospital in Sari in 2020-2021. Method: A cross-sectional study was performed on all patients with renal colic who were admitted to the emergency department in Sari Imam Khomeini Hospital, in 2021. 167 patients with acute renal colic in terms of clinical manifestations, laboratory findings, and CT scan findings were evaluated.Results: In the present study, 55 patients (32.9%) underwent TUL treatment and 112 patients (67.1%) had spontaneous excretion. 48.9% of people with clinical symptoms of abdominal pain and 27% of people without symptoms of abdominal pain finally underwent TUL treatment (p = 0.008). The incidence of TUL in patients with stone size> 5 mm was significantly higher than those with stones ≤5 mm (P <0.001) and the majority of patients with stones in the upper and middle third of the ureter were in the TUL group. The majority of patients had spontaneous excretion despite stones in the lower third and UVJ (p = 0.021).

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Early diagnosis of renal dysfunction in hypertensive patients with type 2 diabetes mellitus

Cited by 2 publications

References 21 publications

The Role of DPP-4 Inhibitors in Type-2 Diabetes Patients with Chronic Kidney Disease

The Role of DPP-4 Inhibitors in Type-2 Diabetes Patients with Chronic Kidney Disease

Prognostic value of clinical signs and CT-scan findings in renal colic patients referred to emergency department of Imam hospital in sari in 2021

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