Early Diagnosis of Myocardial Infarction With Point-of-Care High-Sensitivity Cardiac Troponin I

Boeddinghaus, Jasper; Nestelberger, Thomas; Koechlin, Luca; Wussler, Desiree; Lopez-Ayala, Pedro; Walter, Joan; Troester, Valentina; Ratmann, Paul David; Seidel, Funda; Zimmermann, Tobias; Badertscher, Patrick; Wildi, Karin; Giménez, María Rubini; Potluková, Eliška; Strebel, Ivo; Freese, Michael; Miró, Òscar; Martín‐Sánchez, Francisco Javier; Kawecki, Damian; Keller, Dagmar I.; Gualandro, Danielle Menosi; Christ, Michael; Twerenbold, Raphael; Müeller, Christian; Meier, Mario; Puelacher, Christian; Lavallaz, Jeanne du Fay de; Kozhuharov, Nikola; Rentsch, Katharina; Stelzig, Claudia; Meissner, Kathrin; Kulangara, Caroline; Hillinger, Petra; Michou, Eleni; Flores, Dayana; Reichlin, Tobias; López, Beatriz; Fuenzalida, Carolina; Adrada, Esther Rodríguez; Ganovská, Eva; Lohrmann, Jens; Huber, Jeffrey; Steude, Jana; Buser, Andreas; Eckardstein, Arnold von; Morawiec, Beata; Nowalany-Kozielska, Ewa; Muzyk, Piotr; Bürgler, Franz; Geigy, Nicolas

doi:10.1016/j.jacc.2019.12.065

Cited by 109 publications

(70 citation statements)

References 26 publications

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“…Elevated CTn-I level is an indicator of myocardial membrane damage which causes leakage of cytosolic proteins in to blood stream [ 24 ]. Polyphenols protects cell membrane by virtue of their antioxidant and anti-inflammatory responses [ 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective potential of polyphenols rich Thraatchathi Chooranam against isoproterenol induced myocardial necrosis in experimental rats

Ramakrishnan

Ramachandran

Shivalingaiah

et al. 2020

BMC Complement Med Ther

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Background The present study establishes the cardioprotective role of Thraatchathi Chooranam (TC), a polyherbal traditional Siddha medicine, in terms of membrane stabilizing and antioxidant properties in isoproterenol (ISO) induced myocardial necrosis model in rats. Methods Animals were divided into six groups (n = 6), normal (received vehicle 0.5% CMC, p.o.), ISO control (received 0.5% CMC + ISO 120 mg/kg, b.w. s.c. twice at an interval of 48 h), standard control (received Vit-E 100 mg/kg, p.o.) + ISO, TC low and high dose (50 and 100 mg/kg p.o., respectively) + ISO, and drug control (received TC at 100 mg/kg, p.o.). At the end of experimental period, blood samples collected and plasma cardiac troponin-I (CTn-I) was measured by ELISA. Cardiac tissues were isolated, levels of membrane stabilizing enzymes, antioxidants and inflammatory markers were estimated. Gene expression of Bax, Bcl2, Caspase 3, HIF-α, TNF-α, iNOS, TRX1 and TrxR were performed by RT-PCR. Histopathological studies on cardiac tissues were conducted using hematoxylin and eosin (H&E) stain. Statistical analyses were performed by one-way ANOVA followed by Tukey’s multiple comparison as post-hoc test. Results Administration of ISO resulted in a significant increase in plasma CTn-I, decrease in superoxide dismutase, glutathione and glutathione peroxidase; it also significantly altered membrane stabilizing enzymes like Na+/K+-ATPase, Mg2+-ATPase Ca2+-ATPase and Cathepsin D. Pretreatment with TC (50 mg/kg and 100 mg/kg) decreased CTn-I, and improved membrane stabilizing and endogenous antioxidant enzymes and decreased cathespin D level in a dose dependent manner. Histopathological examination revealed that TC improves cellular membrane integrity and decreases inflammatory cell infiltration and necrotic death. Conclusion The present study provided a strong evidence on the protective effects of TC against ISO-induced myocardial necrosis in rats.

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Section: Discussionmentioning

confidence: 99%

Cardioprotective potential of polyphenols rich Thraatchathi Chooranam against isoproterenol induced myocardial necrosis in experimental rats

Ramakrishnan

Ramachandran

Shivalingaiah

et al. 2020

BMC Complement Med Ther

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“… 33 , 34 cTnI has reliable accuracy for early diagnosis of acute myocardial infarction with an AUC of 0.95. 35 , 36 Levels of cTnI are frequently elevated in patients with HF and can be an indicator for high mortality in emergency departments. 37 Additionally, circulating cTn levels are highly specific for measuring myocardial damage 38 and are associated with acute and advanced chronic HF.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of prealbumin, N-terminal pro-B-type natriuretic peptide, heart type fatty acid binding protein, and cardiac troponin I in elderly patients for heart failure and poor outcomes

Wang¹,

Liu

Guan

et al. 2021

J Int Med Res

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Objectives This study aimed to investigate the prognostic value of serum prealbumin, N-terminal pro-B-type natriuretic peptide (NT-proBNP), heart type fatty acid binding protein (hFABP), and cardiac troponin I (cTnI) for heart failure and cardiac death in elderly patients. Methods We studied 426 consecutive patients with New York Heart Association classes I to IV who were recruited between February 2014 and 2018. Cardiac mortality was the primary end point. Receiver operator characteristic curves were created to analyze predictive values. Results When prealbumin, NT-proBNP, hFABP, and cTnI were combined, the areas under the receiver operator characteristic curve reached 0.930 and 0.903 for heart failure and cardiac death, respectively. Prealbumin, NT-proBNP, hFABP, and cTnI levels changed differently during therapy in patients in different prognosis groups. These parameters improved in patients who did not develop major adverse cardiovascular events (MACEs), but were unchanged or deteriorated in patients with MACEs. Multivariate Cox regression analysis showed that these parameters were significant independent risk factors for MACEs and cardiac death. Conclusions Our study shows that serum prealbumin, NT-proBNP, hFABP, and cTnI levels are significant prognostic factors for elderly patients with poor cardiac function. These parameters are more accurate for prognosis when used together.

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“…Table 2. Hs-cTn values (letters A-E; all values in ng/L) applicable in the ESC 0/1-h algorithm [3,[59][60][61][62][63][64][65][66][67][68]. Letters A-E should be considered together with the ESC 0/1h algorithm provided in the Figure 2.…”

Section: Discussionmentioning

confidence: 99%

“…Thus, the ESC 0/1h should considered as the preferred rapid algorithm, according to both ESC and ESC Acute Cardiovascular Care Association (ACCA) statements [3,52]. (Figure 2 and Table 2 should be interpreted simultaneously) [3,[59][60][61][62][63][64][65][66][67][68].…”

Section: Esc 0/1h and 0/2h-algorithmsmentioning

confidence: 99%

Use of cardiac troponin in the early diagnosis of acute myocardial infarction

Muzyk¹,

Twerenbold²,

Morawiec³

et al. 2020

Kardiol Pol

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Early Diagnosis of Myocardial Infarction With Point-of-Care High-Sensitivity Cardiac Troponin I

Cited by 109 publications

References 26 publications

Cardioprotective potential of polyphenols rich Thraatchathi Chooranam against isoproterenol induced myocardial necrosis in experimental rats

Cardioprotective potential of polyphenols rich Thraatchathi Chooranam against isoproterenol induced myocardial necrosis in experimental rats

Prognostic value of prealbumin, N-terminal pro-B-type natriuretic peptide, heart type fatty acid binding protein, and cardiac troponin I in elderly patients for heart failure and poor outcomes

Use of cardiac troponin in the early diagnosis of acute myocardial infarction

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