Early diagnosis of myocardial infarction by arginase activity determination

Porembska, Zofia; Kedra, M

doi:10.1016/0009-8981(75)90078-9

Cited by 57 publications

(24 citation statements)

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“…The present results imply that both NOS, which converts arginine to citrulline, and arginase, which converts arginine to ornithine, may be elevated in CS patients. The implication of higher arginase activity in CS is consistent with reports of arginase induction by inflammatory cytokines known to be elevated in cardiac ischemia-reperfusion injury and CS 28 and extends reports of increased arginase activity in a number of disease states, including MI, 29 asthma, 30 breast cancer, 31 and pulmonary hypertension. 22,32 NO also can be produced in large and potentially toxic amounts by iNOS expressed in response to trauma and inflammatory stimuli.…”

Section: Discussionsupporting

confidence: 88%

Metabolic Profiling of Arginine and Nitric Oxide Pathways Predicts Hemodynamic Abnormalities and Mortality in Patients With Cardiogenic Shock After Acute Myocardial Infarction

et al. 2007

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Background-It is unclear whether abnormalities of arginine and nitric oxide metabolism are related to hemodynamic dysfunction and mortality in patients with cardiogenic shock (CS) after acute myocardial infarction. Methods and Results-Plasma metabolites reflecting arginine bioavailability, nitric oxide metabolism, and protein oxidation were analyzed by mass spectrometry in patients with CS (nϭ79) and age-and gender-matched patients with coronary artery disease and normal left ventricular function (nϭ79). CS patients had higher levels of asymmetric dimethylarginine (ADMA; PϽ0.0001), symmetric dimethylarginine (PϽ0.0001), monomethylarginine (Pϭ0.0003), nitrotyrosine (PϽ0.0001), and bromotyrosine (PϽ0.0001) and lower levels of arginine (PϽ0.0001), ratio of arginine to ornithine (Pϭ0.03), and ratio of arginine to ornithine plus citrulline) (Pϭ0.0003). CS patients with elevated ADMA levels were 3.5-fold (95% confidence interval, 1.4 to 11.3; Pϭ0.02) more likely to die in 30 days than patients with low ADMA levels. ADMA remained the only independent predictor of mortality on multiple logistic regression analysis. In patients with normal renal function, symmetric dimethylarginine levels inversely correlated with mean arterial pressure and systemic vascular resistance, whereas levels of ADMA correlated with pulmonary capillary wedge pressure and both systolic and diastolic pulmonary artery pressures. Despite dramatic elevations, levels of protein oxidation products did not predict hemodynamic dysfunction or mortality in CS patients. Conclusions-CS is characterized by an arginine-deficient and highly specific pro-oxidant state, with elevated levels of methylated arginine derivatives, including endogenous nitric oxide synthase inhibitors. Levels of methylated arginine derivatives strongly correlate with hemodynamic dysfunction. Among all clinical and laboratory parameters monitored, ADMA levels were the strongest independent predictor of 30-day mortality.

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Section: Discussionsupporting

confidence: 88%

Metabolic Profiling of Arginine and Nitric Oxide Pathways Predicts Hemodynamic Abnormalities and Mortality in Patients With Cardiogenic Shock After Acute Myocardial Infarction

et al. 2007

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“…Previous studies have also failed to detect increased arginase levels in patients with peptic ulcer [23]. Our findings are apparently different from those of Porembska and Kedra [13], who reported elevated serum arginase activity in myocardial infarction and speculated that the necrotic tissue released arginase. However, the release of arginase from macrophages in tissue necrosis may account for the elevated serum arginase in some inflammatory conditions.…”

Section: Discussioncontrasting

confidence: 99%

Immunohistochemical study of arginase in cancer of the stomach

Chung

et al. 1996

Vichows Archiv A Pathol Anat

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High levels of arginase have been detected in gastric adenocarcinoma. To examine the hypothesis that this is due to macrophage infiltration into the tumour, we localized the cellular distribution of arginase by immunohistochemical staining. We examined gastric adenocarcinomas and their corresponding normal tissues (n = 45), leiomyomas (n = 2), leiomyosarcomas (n = 3), human gastric adenocarcinoma cell lines (n = 3), and benign gastric ulcers (n = 4) by the avidin-biotin-peroxidase complex technique. Macrophages with strong arginase immunoreactivity were observed infiltrating both gastric normal and cancer tissues. No arginase immunoreactivity was observed in normal mucosal gland, muscular and serosal tissues or benign gastric ulcers. The immunoreactivity of arginase was positive but heterogeneous in most specimens of gastric adenocarcinoma (62.2%) and was absent from gastric intestinal metaplasia, leiomyomas and leiomyosarcomas. Among the 28 neoplasms with arginase immunoreactivity, scattered immunoreactivity was also noted in adjacent dysplastic glands in 12 (42.8%) specimens. Arginase immunoreactivity was observed in all three gastric cancer cell lines. Arginase is present in the cytoplasm but not in the nucleus. These data suggest that the high arginase levels in adenocarcinoma cancer tissues originate largely from cancer cells.

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“…Brain arginase activity was measured in whole brain homogenate on the basis of formed ornithine, according to the method of Porembska and Kedra [9]. Lipid peroxidation levels (MDA) were determined utilizing thiobarbituric acid [10].…”

Section: Resultsmentioning

confidence: 99%

Effect of caffeine on metabolism of L-arginine in the brain

Nikolić

Bjelaković

Stojanović

2003

Guanidino Compounds in Biology and Medicine

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Methylxanthines are widely consumed because of their stimulating effect primarily on the central nervous system. Their diuretic and respiratory stimulant action is used in clinical medicine. L-Arginine metabolism in the brain is very important for normal brain function. In addition to brain protein synthesis, arginine is a substrate for the production of urea, creatine, nitric oxide, agmatine, glutamic acid, ornithine, proline and polyamines. As known, many of these compounds are very important in brain function. There is no information relating to effects of caffeine on arginine metabolism in the brain, however, there is a lot of new information about arginine metabolism and caffeine action on the central nervous system. So, we have hypothesized the existence of a relationship that may be of interest in understanding mechanisms of caffeine effects on the central nervous system that may have utility in the clinical applications.In our experiment protocol we used male Wistar rats weighing about 200 g. Caffeine was added to the drinking water in gradually increasing amounts, from 2 gil over the first 3 days, to 4 gil over the last 7 days. A control group was given drinking water without caffeine. The level of lipid peroxidation, arginase and diarnine oxidase (DAO) activity in the brain was measured. The results of our study show that arginase and diamine oxidase were decreased in animals treated with caffeine. The level of lipid peroxidation (MDA) was decreased also.The inhibitory effect of caffeine on arginase activity indicates that caffeine provides more arginine for consumption in other metabolic pathways. Considering the central stimulant effects of caffeine and the decreased lipid peroxidation level, it can be assumed that moderate short-term consumption of caffeine may be beneficial for brain function. (Mol Cell Biochem 244: 125-128,2003)

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Early diagnosis of myocardial infarction by arginase activity determination

Cited by 57 publications

References 1 publication

Metabolic Profiling of Arginine and Nitric Oxide Pathways Predicts Hemodynamic Abnormalities and Mortality in Patients With Cardiogenic Shock After Acute Myocardial Infarction

Metabolic Profiling of Arginine and Nitric Oxide Pathways Predicts Hemodynamic Abnormalities and Mortality in Patients With Cardiogenic Shock After Acute Myocardial Infarction

Immunohistochemical study of arginase in cancer of the stomach

Effect of caffeine on metabolism of L-arginine in the brain

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