“…Duquia et al 16 As the syndrome has become more commonly recognized, several groups in the past 5 years have emphasized the importance of early diagnosis, a point pertinent to the present series. 12,19,[47][48][49] The 5 patients described in this review presented with many of the general features of MEN2B, such as marfanoid habitus, bone fragility, ocular lesions, chronic constipation, peripheral muscle weakness, MTC, and, in the 4 patients tested, positivity for RET mutations. All 5 exhibited consistent marfanoid disproportions and all 5 underwent thyroidectomy.…”