Early diagnosis of infection occurs in burned patients and verification in vitro

Zhang, M.; Yang, Lihua; Du, Gang; Duan, Siliang; Liu, Deyun; Gao, Xing; Li, D.

doi:10.1111/ijlh.12810

Cited by 3 publications

(1 citation statement)

References 10 publications

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“…Sepsis can occur due to response of inflammatory process to pathogenic bacteria infection that enter through open wound in burns, especially in burns over 20% of total body surface area [6]. Neutrophil-to-Lymphocyte Ratio (NLR) is an indicator of inflammatory process and can be prognostic index in sepsis [7][8][9][10][11]. Since 2008, various scientific works have stated that the NLR value is related to the degree of inflammatory process and mortality [12,13].…”

Section: Introductionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte Ratio (NLR) as a Prognostic Marker for Burn Patients

Bernadetta¹,

Saputro²,

Zarasade³

2023

IJRP

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BACKGROUND Complications like sepsis due to infection and death can occur in the treatment of major burn trauma patients because of inflammation process. The Neutrophil-to-Lymphocyte Ratio (NLR) is believed as a prognostic marker for the incidence of mortality and sepsis in burns patient care. Various studies have stated that NLR is quite easy, inexpensive and efficient tool for clinical application. AIMS to analyze the role of NLR as prognostic marker for mortality and sepsis in burn patients. METHODS A cross-sectional retrospective single-center study was conducted between 2019 -2021 using 222 medical records from 245 burn patients at our Burns Unit. Demographics and laboratory data results were recorded, including NLR levels on 1 st and 3 rd day of treatment. Correlation analysis of NLR levels was carried out on the incidence of mortality and sepsis using Logistic Regression and Chi Square tests. RESULTSThe subjects of this study were dominated by patients with median age of 33 years old (SD ±20), male (68.5%) and average burns area of 30.22% (SD ±23.3%). This study noted that the NLR on 1 st day (cutoff of 7.97) and 3 rd day (cutoff of 6.2) of treatment had a correlation with the incidence of mortality and sepsis (p<0.05). CONCLUSION Neutrophil-to-Lymphocyte Ratio (NLR) can be used as a prognostic marker of mortality and sepsis in burn patients.

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Section: Introductionmentioning

confidence: 99%

Neutrophil-to-Lymphocyte Ratio (NLR) as a Prognostic Marker for Burn Patients

Bernadetta¹,

Saputro²,

Zarasade³

2023

IJRP

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Admission Neutrophil-Lymphocyte Ratio (NLR) Predicts Survival in Patients with Extensive Burns

Wang

Hong

et al. 2021

Burns

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Diagnostic Value of Neutrophil CD64 in Burn Patients With Infection in Chinese Population: A Systematic Review and Meta-analysis

Chen

Turxun

Ning

et al. 2021

Journal of Burn Care &Amp; Research

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Background Infection is one of the leading causes of death in burn patients. Many researches regard neutrophil CD64 (nCD64) as a biomarker in the early diagnosis of burn patients with infection. Nevertheless, the conclusions are controversial. Methods A comprehensive analysis of the diagnostic value of nCD64 for burn infection was performed in China using a meta-analysis method. Pubmed, Cochrane library, Web of Science, Embase, China National Knowledge Infrastructure (CNKI), and China Wanfang databases were searched for studies on nCD64 as a diagnostic biomarker of burn patients with infection from the establishment of the databases to September 29, 2020. The data was analyzed by Stata 15.0 software. Results Six studies were identified. The results showed that the pooled sensitivity, specificity, positive likelihood ratio, negative likelihood ratio, and DOR were 0.92 (95%CI:0.88~0.95), 0.82 (95%CI:0.76~0.87), 5.10 (95%CI:3.90~6.80), 0.10 (95%CI:0.06~0.15) and 52 (95%CI:29~94), respectively. The area under curve (AUC) was 0.94 (95%CI:0.92~0.94). According to the analysis of the sepsis subgroup, it showed that nCD64 had good diagnostic value in the patients with burn sepsis in Chinese population. Conclusion nCD64 is highly efficient to diagnose burn infection in Chinese population. Therefore, nCD64 could be regarded as a valuable biomarker for early diagnosis of burn infection in China, especially in patients with burn sepsis. Combined with other diagnostic indexes, nCD64 can be clinically used in the early diagnosis of burn infection to improve the sensitivity and specificity.

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Early diagnosis of infection occurs in burned patients and verification in vitro

Abstract: CD64 cells in the peripheral blood of patients with burns complicated by infection increased significantly, and thus, it can be regarded as an early diagnostic indicator of burns with a concurrent infection.

Cited by 3 publications

References 10 publications

Neutrophil-to-Lymphocyte Ratio (NLR) as a Prognostic Marker for Burn Patients

Neutrophil-to-Lymphocyte Ratio (NLR) as a Prognostic Marker for Burn Patients

Admission Neutrophil-Lymphocyte Ratio (NLR) Predicts Survival in Patients with Extensive Burns

Diagnostic Value of Neutrophil CD64 in Burn Patients With Infection in Chinese Population: A Systematic Review and Meta-analysis

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